1E0E
| N-terminal zinc-binding HHCC domain of HIV-2 integrase | 分子名称: | HUMAN IMMUNODEFICIENCY VIRUS TYPE 2 INTEGRASE, ZINC ION | 著者 | Eijkelenboom, A.P.A.M, Van Den ent, F.M.I, Plasterk, R.H.A, Kaptein, R, Boelens, R. | 登録日 | 2000-03-25 | 公開日 | 2001-03-19 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Refined Solution Structure of the Dimeric N-Terminal Hhcc Domain of HIV-2 Integrase J.Biomol.NMR, 18, 2000
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1WJB
| SOLUTION STRUCTURE OF THE N-TERMINAL ZN BINDING DOMAIN OF HIV-1 INTEGRASE (D FORM), NMR, 40 STRUCTURES | 分子名称: | HIV-1 INTEGRASE, ZINC ION | 著者 | Clore, G.M, Cai, M, Caffrey, M, Gronenborn, A.M. | 登録日 | 1997-05-13 | 公開日 | 1998-05-13 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of the N-terminal zinc binding domain of HIV-1 integrase. Nat.Struct.Biol., 4, 1997
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1WJF
| SOLUTION STRUCTURE OF H12C MUTANT OF THE N-TERMINAL ZN BINDING DOMAIN OF HIV-1 INTEGRASE COMPLEXED TO CADMIUM, NMR, 40 STRUCTURES | 分子名称: | CADMIUM ION, HIV-1 INTEGRASE | 著者 | Cai, M, Gronenborn, A.M, Clore, G.M. | 登録日 | 1998-06-11 | 公開日 | 1998-12-16 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of the His12 --> Cys mutant of the N-terminal zinc binding domain of HIV-1 integrase complexed to cadmium. Protein Sci., 7, 1998
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1WJC
| SOLUTION STRUCTURE OF THE N-TERMINAL ZN BINDING DOMAIN OF HIV-1 INTEGRASE (E FORM), NMR, REGULARIZED MEAN STRUCTURE | 分子名称: | HIV-1 INTEGRASE, ZINC ION | 著者 | Clore, G.M, Cai, M, Caffrey, M, Gronenborn, A.M. | 登録日 | 1997-05-13 | 公開日 | 1998-05-13 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of the N-terminal zinc binding domain of HIV-1 integrase. Nat.Struct.Biol., 4, 1997
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1WJE
| SOLUTION STRUCTURE OF H12C MUTANT OF THE N-TERMINAL ZN BINDING DOMAIN OF HIV-1 INTEGRASE COMPLEXED TO CADMIUM, NMR, MINIMIZED AVERAGE STRUCTURE | 分子名称: | CADMIUM ION, HIV-1 INTEGRASE | 著者 | Cai, M, Gronenborn, A.M, Clore, G.M. | 登録日 | 1998-06-11 | 公開日 | 1998-12-16 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of the His12 --> Cys mutant of the N-terminal zinc binding domain of HIV-1 integrase complexed to cadmium. Protein Sci., 7, 1998
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1WJA
| SOLUTION STRUCTURE OF THE N-TERMINAL ZN BINDING DOMAIN OF HIV-1 INTEGRASE (D FORM), NMR, REGULARIZED MEAN STRUCTURE | 分子名称: | HIV-1 INTEGRASE, ZINC ION | 著者 | Clore, G.M, Cai, M, Caffrey, M, Gronenborn, A.M. | 登録日 | 1997-05-13 | 公開日 | 1998-05-13 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of the N-terminal zinc binding domain of HIV-1 integrase. Nat.Struct.Biol., 4, 1997
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1WJD
| SOLUTION STRUCTURE OF THE N-TERMINAL ZN BINDING DOMAIN OF HIV-1 INTEGRASE (E FORM), NMR, 38 STRUCTURES | 分子名称: | HIV-1 INTEGRASE, ZINC ION | 著者 | Clore, G.M, Cai, M, Caffrey, M, Gronenborn, A.M. | 登録日 | 1997-05-13 | 公開日 | 1998-05-13 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of the N-terminal zinc binding domain of HIV-1 integrase. Nat.Struct.Biol., 4, 1997
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5M0R
| Cryo-EM reconstruction of the maedi-visna virus (MVV) strand transfer complex | 分子名称: | integrase, tDNA, vDNA, ... | 著者 | Pye, V.E, Ballandras-Colas, A, Maskell, D, Locke, J, Kotecha, A, Costa, A, Cherepanov, P. | 登録日 | 2016-10-05 | 公開日 | 2017-01-18 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (8.2 Å) | 主引用文献 | A supramolecular assembly mediates lentiviral DNA integration. Science, 355, 2017
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6VRG
| Structure of HIV-1 integrase with native amino-terminal sequence | 分子名称: | Integrase, PHOSPHATE ION, POTASSIUM ION, ... | 著者 | Eilers, G, Gupta, K, Allen, A, Zhou, J, Hwang, Y, Cory, M, Bushman, F.D, Van Duyne, G.D. | 登録日 | 2020-02-07 | 公開日 | 2020-09-09 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Influence of the amino-terminal sequence on the structure and function of HIV integrase. Retrovirology, 17, 2020
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5U1C
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7ZPP
| Cryo-EM structure of the MVV CSC intasome at 4.5A resolution | 分子名称: | Integrase, vDNA, non-transferred strand, ... | 著者 | Ballandras-Colas, A, Maskell, D, Pye, V.E, Locke, J, Swuec, S, Kotecha, A, Costa, A, Cherepanov, P. | 登録日 | 2022-04-28 | 公開日 | 2022-05-11 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | 主引用文献 | A supramolecular assembly mediates lentiviral DNA integration Science, 355, 2017
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4FW2
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5HOT
| Structural Basis for Inhibitor-Induced Aggregation of HIV-1 Integrase | 分子名称: | (2S)-tert-butoxy[4-(8-fluoro-5-methyl-3,4-dihydro-2H-chromen-6-yl)-2-methyl-1-oxo-1,2-dihydroisoquinolin-3-yl]ethanoic acid, Integrase | 著者 | Gupta, K, Turkki, V, Sherrill-Mix, S, Hwang, Y, Eilers, G, Taylor, L, McDanal, C, Wang, P, Temelkoff, D, Nolte, R, Velthuisen, E, Jeffrey, J, Van Duyne, G.D, Bushman, F.D. | 登録日 | 2016-01-19 | 公開日 | 2016-12-14 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (4.4 Å) | 主引用文献 | Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase. PLoS Biol., 14, 2016
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1K6Y
| Crystal Structure of a Two-Domain Fragment of HIV-1 Integrase | 分子名称: | Integrase, PHOSPHATE ION, POTASSIUM ION, ... | 著者 | Wang, J, Ling, H, Yang, W, Craigie, R. | 登録日 | 2001-10-17 | 公開日 | 2001-12-21 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structure of a two-domain fragment of HIV-1 integrase: implications for domain organization in the intact protein. EMBO J., 20, 2001
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7JN3
| Cryo-EM structure of Rous sarcoma virus cleaved synaptic complex (CSC) with HIV-1 integrase strand transfer inhibitor MK-2048 | 分子名称: | (6S)-2-(3-chloro-4-fluorobenzyl)-8-ethyl-10-hydroxy-N,6-dimethyl-1,9-dioxo-1,2,6,7,8,9-hexahydropyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-4-carboxamide, DNA (5'-D(*AP*AP*TP*GP*TP*TP*GP*TP*CP*TP*TP*AP*TP*GP*CP*AP*AP*T)-3'), DNA (5'-D(*AP*TP*TP*GP*CP*AP*TP*AP*AP*GP*AP*CP*AP*AP*CP*A)-3'), ... | 著者 | Pandey, K.K, Bera, S, Shi, K, Aihara, H, Grandgenett, D.P. | 登録日 | 2020-08-03 | 公開日 | 2021-03-17 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.21 Å) | 主引用文献 | Cryo-EM structure of the Rous sarcoma virus octameric cleaved synaptic complex intasome. Commun Biol, 4, 2021
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3F9K
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7Z1Z
| MVV strand transfer complex (STC) intasome in complex with LEDGF/p75 at 3.5 A resolution | 分子名称: | DNA (37-MER), DNA (5'-D(*GP*CP*TP*GP*CP*GP*AP*GP*AP*TP*CP*CP*GP*CP*TP*CP*CP*GP*GP*TP*G)-3'), DNA (5'-D(P*TP*TP*GP*AP*TP*TP*AP*GP*GP*GP*TP*G)-3'), ... | 著者 | Pye, V.E, Ballandras-Colas, A, Cherepanov, P. | 登録日 | 2022-02-25 | 公開日 | 2022-05-11 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Multivalent interactions essential for lentiviral integrase function. Nat Commun, 13, 2022
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7KUI
| Cryo-EM structure of Rous sarcoma virus cleaved synaptic complex (CSC) with HIV-1 integrase strand transfer inhibitor MK-2048. CIC region of a cluster identified by 3-dimensional variability analysis in cryoSPARC. | 分子名称: | (6S)-2-(3-chloro-4-fluorobenzyl)-8-ethyl-10-hydroxy-N,6-dimethyl-1,9-dioxo-1,2,6,7,8,9-hexahydropyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-4-carboxamide, DNA (5'-D(*AP*AP*TP*GP*TP*TP*GP*TP*CP*TP*TP*AP*TP*GP*CP*AP*AP*T)-3'), DNA (5'-D(*AP*TP*TP*GP*CP*AP*TP*AP*AP*GP*AP*CP*AP*AP*CP*A)-3'), ... | 著者 | Pandey, K.K, Bera, S, Shi, K, Aihara, H, Grandgenett, D.P. | 登録日 | 2020-11-25 | 公開日 | 2021-03-17 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Cryo-EM structure of the Rous sarcoma virus octameric cleaved synaptic complex intasome. Commun Biol, 4, 2021
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7KU7
| Cryo-EM structure of Rous sarcoma virus cleaved synaptic complex (CSC) with HIV-1 integrase strand transfer inhibitor MK-2048. Cluster identified by 3-dimensional variability analysis in cryoSPARC. | 分子名称: | (6S)-2-(3-chloro-4-fluorobenzyl)-8-ethyl-10-hydroxy-N,6-dimethyl-1,9-dioxo-1,2,6,7,8,9-hexahydropyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-4-carboxamide, DNA (5'-D(*AP*AP*TP*GP*TP*TP*GP*TP*CP*TP*TP*AP*TP*GP*CP*AP*AP*T)-3'), DNA (5'-D(*AP*TP*TP*GP*CP*AP*TP*AP*AP*GP*AP*CP*AP*AP*CP*A)-3'), ... | 著者 | Pandey, K.K, Bera, S, Shi, K, Aihara, H, Grandgenett, D.P. | 登録日 | 2020-11-24 | 公開日 | 2021-03-17 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Cryo-EM structure of the Rous sarcoma virus octameric cleaved synaptic complex intasome. Commun Biol, 4, 2021
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5CZ2
| Crystal structure of a two-domain fragment of MMTV integrase | 分子名称: | MAGNESIUM ION, Pol polyprotein, ZINC ION | 著者 | Cook, N, Ballandras-Colas, A, Engelman, A, Cherepanov, P. | 登録日 | 2015-07-31 | 公開日 | 2016-02-17 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.72 Å) | 主引用文献 | Cryo-EM reveals a novel octameric integrase structure for betaretroviral intasome function. Nature, 530, 2016
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5EJK
| Crystal structure of the Rous sarcoma virus intasome | 分子名称: | DNA (5'-D(*AP*AP*TP*GP*TP*TP*GP*TP*CP*TP*TP*AP*TP*GP*CP*AP*AP*TP*AP*CP*TP*C)-3'), DNA (5'-D(*AP*GP*TP*GP*TP*CP*TP*T)-3'), DNA (5'-D(*CP*TP*TP*CP*TP*CP*TP*C)-3'), ... | 著者 | Yin, Z, Shi, K, Banerjee, S, Aihara, H. | 登録日 | 2015-11-02 | 公開日 | 2016-02-17 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | 主引用文献 | Crystal structure of the Rous sarcoma virus intasome. Nature, 530, 2016
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3HPG
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3HPH
| Closed tetramer of Visna virus integrase (residues 1-219) in complex with LEDGF IBD | 分子名称: | GLYCEROL, Integrase, PC4 and SFRS1-interacting protein, ... | 著者 | Hare, S, Wang, J, Cherepanov, P. | 登録日 | 2009-06-04 | 公開日 | 2009-07-28 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.64 Å) | 主引用文献 | Structural basis for functional tetramerization of lentiviral integrase Plos Pathog., 5, 2009
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3JCA
| Core model of the Mouse Mammary Tumor Virus intasome | 分子名称: | 5'-D(*AP*AP*TP*GP*CP*CP*GP*CP*AP*GP*TP*CP*GP*GP*CP*CP*GP*AP*CP*CP*TP*G)-3', 5'-D(*CP*AP*GP*GP*TP*CP*GP*GP*CP*CP*GP*AP*CP*TP*GP*CP*GP*GP*CP*A)-3', Integrase, ... | 著者 | Lyumkis, D.L, Ballandras-Colas, A, Brown, M, Cook, N.J, Dewdney, T.G, Demeler, B, Cherepanov, P, Engelman, A.N. | 登録日 | 2015-11-24 | 公開日 | 2016-02-17 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (4.8 Å) | 主引用文献 | Cryo-EM reveals a novel octameric integrase structure for betaretroviral intasome function. Nature, 530, 2016
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8W2R
| HIV-1 P5-IN intasome core | 分子名称: | (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, DNA (5'-D(*AP*CP*TP*GP*CP*TP*AP*GP*AP*GP*AP*TP*TP*TP*TP*CP*CP*CP*G)-3'), DNA (5'-D(P*CP*GP*GP*GP*AP*AP*AP*AP*TP*CP*TP*CP*TP*AP*GP*CP*A)-3'), ... | 著者 | Li, M, Craigie, R. | 登録日 | 2024-02-21 | 公開日 | 2024-04-17 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (3.23 Å) | 主引用文献 | HIV-1 Integrase Assembles Multiple Species of Stable Synaptic Complex Intasomes That Are Active for Concerted DNA Integration In vitro. J.Mol.Biol., 436, 2024
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