7KU7

Cryo-EM structure of Rous sarcoma virus cleaved synaptic complex (CSC) with HIV-1 integrase strand transfer inhibitor MK-2048. Cluster identified by 3-dimensional variability analysis in cryoSPARC.

Summary for 7KU7

• Entry DOI: 10.2210/pdb7ku7/pdb
• EMDB information: 22400 23035
• Descriptor: integrase, DNA (5'-D(*AP*AP*TP*GP*TP*TP*GP*TP*CP*TP*TP*AP*TP*GP*CP*AP*AP*T)-3'), DNA (5'-D(*AP*TP*TP*GP*CP*AP*TP*AP*AP*GP*AP*CP*AP*AP*CP*A)-3'), ... (6 entities in total)
• Functional Keywords: intasome, integrase-viral dna complex, hydrolase-dna-inhibitor complex, hydrolase/dna/inhibitor
• Biological source: Rous sarcoma virus (strain Schmidt-Ruppin A) (RSV-PrC); More
• Total number of polymer chains: 12
• Total formula weight: 269404.11

Authors

Pandey, K.K.,Bera, S.,Shi, K.,Aihara, H.,Grandgenett, D.P. (deposition date: 2020-11-24, release date: 2021-03-17, Last modification date: 2024-03-06)

• Primary citation: Pandey, K.K.,Bera, S.,Shi, K.,Rau, M.J.,Oleru, A.V.,Fitzpatrick, J.A.J.,Engelman, A.N.,Aihara, H.,Grandgenett, D.P.; Cryo-EM structure of the Rous sarcoma virus octameric cleaved synaptic complex intasome.; Commun Biol, 4:330-330, 2021; PubMed: 33712691; DOI: 10.1038/s42003-021-01855-2

Experimental method

ELECTRON MICROSCOPY (3.4 Å)