5M2Z
| Crystal structure of the full-length Zika virus NS5 protein (Human isolate Z1106033) | 分子名称: | NS5, PHOSPHATE ION, S-ADENOSYL-L-HOMOCYSTEINE, ... | 著者 | Ferrero, D.S, Ruiz-Arroyo, V.M, Soler, N, Uson, I, Verdaguer, N. | 登録日 | 2016-10-13 | 公開日 | 2018-06-06 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (4.8 Å) | 主引用文献 | Supramolecular arrangement of the full-length Zika virus NS5. Plos Pathog., 15, 2019
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5WZ3
| Crystal structure of Zika virus NS5 RNA-dependent RNA polymerase(RdRP) | 分子名称: | NS5 RdRp, ZINC ION | 著者 | Duan, W, Song, H, Qi, J, Shi, Y, Gao, G.F. | 登録日 | 2017-01-16 | 公開日 | 2017-03-08 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.804 Å) | 主引用文献 | The crystal structure of Zika virus NS5 reveals conserved drug targets. EMBO J., 36, 2017
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4V0R
| DENGUE VIRUS FULL LENGTH NS5 COMPLEXED WITH GTP AND SAH | 分子名称: | FORMIC ACID, GLYCEROL, GUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Zhao, Y, Soh, S, Zheng, J, Phoo, W.W, Swaminathan, K, Cornvik, T.C, Lim, S.P, Shi, P.-Y, Lescar, J, Vasudevan, S.G, Luo, D. | 登録日 | 2014-09-18 | 公開日 | 2015-01-28 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | A Crystal Structure of the Dengue Virus Ns5 Protein Reveals a Novel Inter-Domain Interface Essential for Protein Flexibility and Virus Replication. Plos Pathog., 11, 2015
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4V0Q
| Dengue Virus Full Length NS5 Complexed with SAH | 分子名称: | ACETATE ION, GLYCEROL, NS5 POLYMERASE, ... | 著者 | Zhao, Y, Soh, S, Zheng, J, Phoo, W.W, Swaminathan, K, Cornvik, T.C, Lim, S.P, Shi, P.-Y, Lescar, J, Vasudevan, S.G, Luo, D. | 登録日 | 2014-09-18 | 公開日 | 2015-01-28 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | A Crystal Structure of the Dengue Virus Ns5 Protein Reveals a Novel Inter-Domain Interface Essential for Protein Flexibility and Virus Replication. Plos Pathog., 11, 2015
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6I7P
| Crystal structure of the full-length Zika virus NS5 protein (Human isolate Z1106033) | 分子名称: | NS5, PHOSPHATE ION, S-ADENOSYL-L-HOMOCYSTEINE, ... | 著者 | Ferrero, D.S, Ruiz-Arroyo, V.M, Soler, N, Uson, I, Verdaguer, N. | 登録日 | 2018-11-16 | 公開日 | 2019-04-24 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (3.975 Å) | 主引用文献 | Supramolecular arrangement of the full-length Zika virus NS5. Plos Pathog., 15, 2019
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7ZIU
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6QSN
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5ZQK
| Dengue Virus Non Structural Protein 5 | 分子名称: | 1,2-ETHANEDIOL, GLYCEROL, MAGNESIUM ION, ... | 著者 | El Sahili, A, Soh, T.S, Schiltz, J, Gharbi-Ayachi, A, Goh, B.C, Seh, C.C, Dedon, P.C, Shi, P.Y, Lim, S.P, Lescar, J. | 登録日 | 2018-04-19 | 公開日 | 2019-06-12 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | NS5 from Dengue Virus Serotype 2 Can Adopt a Conformation Analogous to That of Its Zika Virus and Japanese Encephalitis Virus Homologues. J.Virol., 94, 2019
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7D6N
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4MTP
| RdRp from Japanesese Encephalitis Virus | 分子名称: | RNA dependent RNA polymerase, ZINC ION | 著者 | Surana, P, Nair, D.T. | 登録日 | 2013-09-20 | 公開日 | 2013-12-25 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (3.65 Å) | 主引用文献 | RNA-dependent RNA polymerase of Japanese encephalitis virus binds the initiator nucleotide GTP to form a mechanistically important pre-initiation state. Nucleic Acids Res., 42, 2014
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4C11
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5TFR
| Crystal structure of Zika Virus NS5 protein | 分子名称: | Genome polyprotein, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION | 著者 | Longenecker, K.L, Upadhyay, A.K. | 登録日 | 2016-09-26 | 公開日 | 2016-10-12 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | 主引用文献 | Crystal structure of full-length Zika virus NS5 protein reveals a conformation similar to Japanese encephalitis virus NS5. Acta Crystallogr F Struct Biol Commun, 73, 2017
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3VWS
| Dengue serotype 3 RNA-dependent RNA polymerase bound to NITD-107 | 分子名称: | 5-{[(4-chlorophenyl)sulfonyl]amino}-2-methyl-1-benzofuran-3-carboxylic acid, DI(HYDROXYETHYL)ETHER, Non-structural protein 5, ... | 著者 | Noble, C.G, Lescar, J. | 登録日 | 2012-08-31 | 公開日 | 2013-02-27 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Conformational flexibility of the Dengue virus RNA-dependent RNA polymerase revealed by a complex with an inhibitor J.Virol., 87, 2013
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4HDG
| Crystal Structure of viral RdRp in complex with GTP | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, Polyprotein, ZINC ION | 著者 | Surana, P, Nair, D.T. | 登録日 | 2012-10-02 | 公開日 | 2013-12-25 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.38 Å) | 主引用文献 | RNA-dependent RNA polymerase of Japanese encephalitis virus binds the initiator nucleotide GTP to form a mechanistically important pre-initiation state. Nucleic Acids Res., 42, 2014
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4K6M
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6H80
| Dengue-RdRp3-inhibitor complex co-crystallisation | 分子名称: | 2-(4-methoxy-3-thiophen-2-yl-phenyl)ethanoic acid, DI(HYDROXYETHYL)ETHER, Genome polyprotein, ... | 著者 | Talapatra, S.K, Kozielski, F. | 登録日 | 2018-07-31 | 公開日 | 2019-03-13 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Development and validation of RdRp Screen, a crystallization screen for viral RNA-dependent RNA polymerases. Biol Open, 8, 2019
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6H9R
| Dengue-RdRp3-inhibitor complex soaking | 分子名称: | 2-(4-methoxy-3-thiophen-2-yl-phenyl)ethanoic acid, DI(HYDROXYETHYL)ETHER, Genome polyprotein, ... | 著者 | Talapatra, S.K, Kozielski, F. | 登録日 | 2018-08-05 | 公開日 | 2019-03-13 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Development and validation of RdRp Screen, a crystallization screen for viral RNA-dependent RNA polymerases. Biol Open, 8, 2019
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7XD9
| Crystal Structure of Dengue Virus serotype 2 (DENV2) Polymerase Elongation Complex (CTP Form) | 分子名称: | CYTIDINE-5'-TRIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... | 著者 | Wu, J, Wang, X, Gong, P. | 登録日 | 2022-03-26 | 公開日 | 2022-12-21 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.58 Å) | 主引用文献 | Structural basis of transition from initiation to elongation in de novo viral RNA-dependent RNA polymerases. Proc.Natl.Acad.Sci.USA, 120, 2023
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7XD8
| Crystal Structure of Dengue Virus Serotype 2 (DENV2) Polymerase Elongation Complex (Native Form) | 分子名称: | GLYCEROL, NS5, RNA (30-mer), ... | 著者 | Wu, J, Wang, X, Gong, P. | 登録日 | 2022-03-26 | 公開日 | 2022-12-21 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Structural basis of transition from initiation to elongation in de novo viral RNA-dependent RNA polymerases. Proc.Natl.Acad.Sci.USA, 120, 2023
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4HDH
| Crystal Structure of viral RdRp in complex with ATP | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Polyprotein, ZINC ION | 著者 | Surana, P, Nair, D.T. | 登録日 | 2012-10-02 | 公開日 | 2013-12-25 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | 主引用文献 | RNA-dependent RNA polymerase of Japanese encephalitis virus binds the initiator nucleotide GTP to form a mechanistically important pre-initiation state. Nucleic Acids Res., 42, 2014
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4HHJ
| Dengue serotype 3 RNA-dependent RNA polymerase | 分子名称: | DI(HYDROXYETHYL)ETHER, HEXAETHYLENE GLYCOL, Non-structural protein 5, ... | 著者 | Noble, C.G, Lescar, J. | 登録日 | 2012-10-10 | 公開日 | 2013-02-27 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | 主引用文献 | Conformational flexibility of the Dengue virus RNA-dependent RNA polymerase revealed by a complex with an inhibitor J.Virol., 87, 2013
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8GZP
| Cryo-EM structure of the NS5-SLA complex | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, Genome polyprotein, MAGNESIUM ION, ... | 著者 | Osawa, T, Ehara, H, Sekine, S. | 登録日 | 2022-09-27 | 公開日 | 2023-08-02 | 最終更新日 | 2023-08-23 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structures of dengue virus RNA replicase complexes. Mol.Cell, 83, 2023
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6XD1
| Dengue serotype 3 RNA-dependent RNA polymerase bound to NITD-640 | 分子名称: | (2R)-4-(butyl{[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl}carbamoyl)-1-(2,2-diphenylpropanoyl)piperazine-2-carboxylic acid, RNA-dependent RNA polymerase, ZINC ION | 著者 | Arora, R, Benson, T.E, Liew, C.W, Lescar, J. | 登録日 | 2020-06-09 | 公開日 | 2020-09-23 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.954 Å) | 主引用文献 | Two RNA Tunnel Inhibitors Bind in Highly Conserved Sites in Dengue Virus NS5 Polymerase: Structural and Functional Studies. J.Virol., 94, 2020
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6XD0
| Dengue serotype 3 RNA-dependent RNA polymerase bound to NITD-434 | 分子名称: | 2-[({2-[(2,6-dichlorophenyl)amino]phenyl}acetyl)amino]-2,3-dihydro-1H-indene-2-carboxylic acid, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | 著者 | Arora, R, Benson, T.E, Liew, C.W, Lescar, J. | 登録日 | 2020-06-09 | 公開日 | 2020-09-23 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.012 Å) | 主引用文献 | Two RNA Tunnel Inhibitors Bind in Highly Conserved Sites in Dengue Virus NS5 Polymerase: Structural and Functional Studies. J.Virol., 94, 2020
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5U0C
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