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5TSN
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BU of 5tsn by Molmil
Crystal structures of Norwalk virus polymerase bound to an RNA primer-template duplex
分子名称: MANGANESE (II) ION, Norwalk virus polymerase, RNA (5'-R(*UP*GP*CP*CP*CP*GP*GP*G)-3')
著者Shaik, M.M, Ng, K.K.
登録日2016-10-30
公開日2017-04-12
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Norovirus RNA-dependent RNA polymerase: A computational study of metal-binding preferences.
Proteins, 85, 2017
5XE0
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BU of 5xe0 by Molmil
Crystal structure of EV-D68-3Dpol in complex with GTP
分子名称: GUANOSINE-5'-TRIPHOSPHATE, Genome polyprotein
著者Xie, W, Wang, C, Wang, Z, Li, Q, Wang, C.
登録日2017-03-30
公開日2017-06-28
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal Structure and Thermostability Characterization of Enterovirus D68 3Dpol
J. Virol., 91, 2017
3KMS
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BU of 3kms by Molmil
G62S mutant of foot-and-mouth disease virus RNA-polymerase in complex with a template- primer RNA trigonal structure
分子名称: 3D polymerase, MAGNESIUM ION, RNA (5'-R(*AP*UP*GP*GP*GP*CP*C)-3'), ...
著者Ferrer-Orta, C, Verdaguer, N, Perez-Luque, R.
登録日2009-11-11
公開日2010-07-07
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structure of foot-and-mouth disease virus mutant polymerases with reduced sensitivity to ribavirin
J.Virol., 84, 2010
5JXS
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BU of 5jxs by Molmil
Mutant GC216/7AA of 3D polymerase from Foot-and-Mouth Disease Virus
分子名称: MAGNESIUM ION, RNA Primer, RNA Template, ...
著者Verdaguer, N, Ferrer-Orta, C.
登録日2016-05-13
公開日2016-06-01
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Both cis and trans Activities of Foot-and-Mouth Disease Virus 3D Polymerase Are Essential for Viral RNA Replication.
J.Virol., 90, 2016
7W9S
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BU of 7w9s by Molmil
Crystal structure of the enterovirus 71 polymerase elongation complex (C1S3 form)
分子名称: CYTIDINE-5'-TRIPHOSPHATE, Genome polyprotein, MAGNESIUM ION, ...
著者Wang, M, Gong, P.
登録日2021-12-10
公開日2022-11-16
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.53 Å)
主引用文献Crystal structure of a pre-chemistry viral RNA-dependent RNA polymerase suggests participation of two basic residues in catalysis.
Nucleic Acids Res., 50, 2022
8C2P
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BU of 8c2p by Molmil
FMDV 3D polymerase in complex with 3B3
分子名称: Protein 3B-3, RNA-directed RNA polymerase 3D-POL
著者Ferrer-Orta, C, Veraguer, N.
登録日2022-12-22
公開日2023-04-26
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Dual role of the foot-and-mouth disease virus 3B1 protein in the replication complex: As protein primer and as an essential component to recruit 3Dpol to membranes.
Plos Pathog., 19, 2023
8C1N
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BU of 8c1n by Molmil
FMDV 3D polymerase in complex with 3B1 protein solved in P212121 space group
分子名称: ACETATE ION, GLYCEROL, Protein 3B-1, ...
著者Ferrer-Orta, C, Veraguer, N.
登録日2022-12-20
公開日2023-04-26
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Dual role of the foot-and-mouth disease virus 3B1 protein in the replication complex: As protein primer and as an essential component to recruit 3Dpol to membranes.
Plos Pathog., 19, 2023
1HHS
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BU of 1hhs by Molmil
RNA dependent RNA polymerase from dsRNA bacteriophage phi6
分子名称: MANGANESE (II) ION, RNA-DIRECTED RNA POLYMERASE
著者Grimes, J.M, Butcher, S.J, Makeyev, E.V, Bamford, D.H, Stuart, D.I.
登録日2000-12-28
公開日2001-03-27
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献A Mechanism for Initiating RNA-Dependent RNA Polymerization
Nature, 410, 2001
1HHT
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BU of 1hht by Molmil
RNA dependent RNA polymerase from dsRNA bacteriophage phi6 plus template
分子名称: DNA (5'-(*TP*TP*TP*CP*C)-3'), MANGANESE (II) ION, P2 PROTEIN
著者Grimes, J.M, Butcher, S.J, Makeyev, E.V, Bamford, D.H, Stuart, D.I.
登録日2000-12-28
公開日2001-03-27
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献A Mechanism for Initiating RNA-Dependent RNA Polymerization
Nature, 410, 2001
3H5Y
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BU of 3h5y by Molmil
Norovirus polymerase+primer/template+CTP complex at 6 mM MnCl2
分子名称: 5'-R(*UP*GP*CP*CP*CP*GP*GP*G)-3', 5'-R(P*UP*GP*CP*CP*CP*GP*GP*GP*C)-3', CYTIDINE-5'-TRIPHOSPHATE, ...
著者Zamyatkin, D.F, Parra, F, Machin, A, Grochulski, P, Ng, K.K.S.
登録日2009-04-22
公開日2009-05-19
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.77 Å)
主引用文献Binding of 2'-amino-2'-deoxycytidine-5'-triphosphate to norovirus polymerase induces rearrangement of the active site.
J.Mol.Biol., 390, 2009
3H5X
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BU of 3h5x by Molmil
Crystal Structure of 2'-amino-2'-deoxy-cytidine-5'-triphosphate bound to Norovirus GII RNA polymerase
分子名称: 2'-amino-2'-deoxycytidine 5'-(tetrahydrogen triphosphate), 5'-R(*UP*GP*CP*CP*CP*GP*GP*G)-3', 5'-R(P*UP*GP*CP*CP*CP*GP*GP*GP*C)-3', ...
著者Zamyatkin, D.F, Parra, F, Machin, A, Grochulski, P, Ng, K.K.S.
登録日2009-04-22
公開日2009-05-19
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.77 Å)
主引用文献Binding of 2'-amino-2'-deoxycytidine-5'-triphosphate to norovirus polymerase induces rearrangement of the active site.
J.Mol.Biol., 390, 2009
4R0E
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BU of 4r0e by Molmil
Crystal Structure of the Poliovirus RNA-Dependent RNA Polymerase Low-Fidelity Mutant 3Dpol H273R
分子名称: RNA-directed RNA polymerase
著者Marcotte, L.L, Gohara, D.W, Filman, D.J, Hogle, J.M.
登録日2014-07-30
公開日2014-11-12
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structural Dynamics as a Contributor to Error-prone Replication by an RNA-dependent RNA Polymerase.
J.Biol.Chem., 289, 2014
5N8X
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BU of 5n8x by Molmil
Trigonal structure of mutant V173I of 3D polymerase from Foot-and-Mouth Disease Virus
分子名称: 3D polymerase, GLYCEROL, MANGANESE (II) ION
著者Ferrer-Orta, C, Verdaguer, N.
登録日2017-02-24
公開日2017-05-10
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Molecular and Functional Bases of Selection against a Mutation Bias in an RNA Virus.
Genome Biol Evol, 9, 2017
5N95
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BU of 5n95 by Molmil
Tetragonal structure of mutant V173I of 3D polymerase from Foot-and-Mouth Disease Virus
分子名称: 3D polymerase, TRIPHOSPHATE
著者Ferrer-Orta, C, Verdaguer, N.
登録日2017-02-24
公開日2017-05-10
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Molecular and Functional Bases of Selection against a Mutation Bias in an RNA Virus.
Genome Biol Evol, 9, 2017
4QPX
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BU of 4qpx by Molmil
NV polymerase post-incorporation-like complex
分子名称: GLYCEROL, MANGANESE (II) ION, Polyprotein, ...
著者Zamyatkin, D.F, Parra, F, Grochulski, P, Ng, K.K.S.
登録日2014-06-25
公開日2015-04-22
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献Structure of a backtracked state reveals conformational changes similar to the state following nucleotide incorporation in human norovirus polymerase.
Acta Crystallogr.,Sect.D, 70, 2014
6GVV
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BU of 6gvv by Molmil
Mutant M16A of RNA dependent RNA polymerase 3D from Foot-and-Mouth disease Virus
分子名称: GLYCEROL, RNA polymerase 3D
著者Verdaguer, N, Ferrer Orta, C.
登録日2018-06-21
公開日2018-08-01
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Contribution of a Multifunctional Polymerase Region of Foot-and-Mouth Disease Virus to Lethal Mutagenesis.
J.Virol., 92, 2018
6GVY
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BU of 6gvy by Molmil
Mutant M16A of RNA dependent RNA polymerase 3D from Foot-and-Mouth disease Virus complexed with an template -primer RNA
分子名称: GLYCEROL, Genome polyprotein, RNA (5'-R(P*CP*CP*GP*GP*G)-3'), ...
著者Verdaguer, N, Ferrer-Orta, C.
登録日2018-06-21
公開日2018-08-01
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Contribution of a Multifunctional Polymerase Region of Foot-and-Mouth Disease Virus to Lethal Mutagenesis.
J. Virol., 92, 2018
5I62
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BU of 5i62 by Molmil
Crystal structure of the insertion loop deletion mutant of the RNA-dependent RNA polymerase of a human picorbirnavirus
分子名称: Potential RNA-dependent RNA polymerase
著者Collier, A.M, Guo, Y.R, Tao, Y.J.
登録日2016-02-15
公開日2016-03-16
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.001 Å)
主引用文献Initiation of RNA Polymerization and Polymerase Encapsidation by a Small dsRNA Virus.
Plos Pathog., 12, 2016
5I61
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BU of 5i61 by Molmil
Crystal structure of the RNA-dependent RNA polymerase of a human picorbirnavirus
分子名称: Potential RNA-dependent RNA polymerase
著者Collier, A.M, Guo, Y.R, Tao, Y.J.
登録日2016-02-15
公開日2016-03-16
最終更新日2019-12-11
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Initiation of RNA Polymerization and Polymerase Encapsidation by a Small dsRNA Virus.
Plos Pathog., 12, 2016
3BSN
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BU of 3bsn by Molmil
Norwalk Virus polymerase bound to 5-nitrocytidine triphosphate and primer-template RNA
分子名称: 5-nitrocytidine 5'-(tetrahydrogen triphosphate), GLYCEROL, MANGANESE (II) ION, ...
著者Zamyatkin, D.F, Ng, K.K.S.
登録日2007-12-26
公開日2008-01-08
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural insights into mechanisms of catalysis and inhibition in norwalk virus polymerase.
J.Biol.Chem., 283, 2008
3BSO
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BU of 3bso by Molmil
Norwalk Virus polymerase bound to cytidine 5'-triphosphate and primer-template RNA
分子名称: CYTIDINE-5'-TRIPHOSPHATE, GLYCEROL, MANGANESE (II) ION, ...
著者Zamyatkin, D.F, Ng, K.K.S.
登録日2007-12-26
公開日2008-01-08
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.74 Å)
主引用文献Structural insights into mechanisms of catalysis and inhibition in norwalk virus polymerase.
J.Biol.Chem., 283, 2008
4Y34
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BU of 4y34 by Molmil
Crystal Structure of Coxsackievirus B3 3D polymerase in complex with GPC-N143
分子名称: 2,2'-[(4-fluorobenzene-1,2-diyl)bis(oxy)]bis(5-nitrobenzonitrile), 3D polymerase, GLYCEROL, ...
著者Vives-Adrian, L, Ferrer-Orta, C, Cerdaguer, N.
登録日2015-02-10
公開日2015-04-01
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献The RNA Template Channel of the RNA-Dependent RNA Polymerase as a Target for Development of Antiviral Therapy of Multiple Genera within a Virus Family.
Plos Pathog., 11, 2015
4Y3C
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BU of 4y3c by Molmil
I304V 3D polymerase mutant of EMCV
分子名称: 3D polymerase, CHLORIDE ION, GLYCEROL
著者Verdaguer, N, Ferrer-Orta, C, Vives-Adrian, L.
登録日2015-02-10
公開日2015-04-01
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献The RNA Template Channel of the RNA-Dependent RNA Polymerase as a Target for Development of Antiviral Therapy of Multiple Genera within a Virus Family.
Plos Pathog., 11, 2015
4Y2C
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BU of 4y2c by Molmil
M300V 3D polymerase mutant of EMCV
分子名称: GLYCEROL, Genome polyprotein
著者Verdaguer, N, Ferrer-Orta, C, Vives-Adrian, L.
登録日2015-02-09
公開日2015-04-01
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献The RNA Template Channel of the RNA-Dependent RNA Polymerase as a Target for Development of Antiviral Therapy of Multiple Genera within a Virus Family.
Plos Pathog., 11, 2015
3CDU
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BU of 3cdu by Molmil
Crystal structure of coxsackievirus B3 RNA-dependent RNA polymerase (3Dpol) in complex with a pyrophosphate
分子名称: ACETATE ION, CHLORIDE ION, GLYCEROL, ...
著者Gruez, A, Selisko, B, Roberts, M, Bricogne, G, Bussetta, C, Canard, B.
登録日2008-02-27
公開日2008-07-22
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献The crystal structure of coxsackievirus B3 RNA-dependent RNA polymerase in complex with its protein primer VPg confirms the existence of a second VPg binding site on Picornaviridae polymerases
J.Virol., 82, 2008

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