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8X54	Cryo-EM structure of human gamma-secretase in complex with APP-C99 Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Guo, X, Yan, C, Lei, J, Zhou, R, Shi, Y. Deposit date: 2023-11-16 Release date: 2024-05-29 Last modified: 2024-06-19 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Molecular mechanism of substrate recognition and cleavage by human gamma-secretase. Science, 384, 2024
8X52	Cryo-EM structure of human gamma-secretase in complex with Abeta49 Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Guo, X, Yan, C, Lei, J, Zhou, R, Shi, Y. Deposit date: 2023-11-16 Release date: 2024-05-29 Last modified: 2024-06-19 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Molecular mechanism of substrate recognition and cleavage by human gamma-secretase. Science, 384, 2024
8X53	Cryo-EM structure of human gamma-secretase in complex with Abeta46 Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Guo, X, Yan, C, Lei, J, Zhou, R, Shi, Y. Deposit date: 2023-11-16 Release date: 2024-05-29 Last modified: 2024-06-19 Method: ELECTRON MICROSCOPY (3 Å) Cite: Molecular mechanism of substrate recognition and cleavage by human gamma-secretase. Science, 384, 2024
8QN7	Amyloid-beta 40 type 1 filament from the leptomeninges of individual with Alzheimer's disease and cerebral amyloid angiopathy Descriptor: Amyloid-beta A4 protein Authors: Yang, Y, Murzin, A.S, Peak-Chew, S.Y, Franco, C, Newell, K.L, Ghetti, B, Goedert, M, Scheres, S.H.W. Deposit date: 2023-09-25 Release date: 2023-12-13 Last modified: 2024-01-31 Method: ELECTRON MICROSCOPY (2.7 Å) Cite: Cryo-EM structures of A beta 40 filaments from the leptomeninges of individuals with Alzheimer's disease and cerebral amyloid angiopathy. Acta Neuropathol Commun, 11, 2023
8QN6	Amyloid-beta 40 type 2 filament from the leptomeninges of individual with Alzheimer's disease and cerebral amyloid angiopathy Descriptor: Amyloid-beta A4 protein Authors: Yang, Y, Murzin, A.S, Peak-Chew, S.Y, Franco, C, Newell, K.L, Ghetti, B, Goedert, M, Scheres, S.H.W. Deposit date: 2023-09-25 Release date: 2023-12-13 Last modified: 2024-01-31 Method: ELECTRON MICROSCOPY (2.4 Å) Cite: Cryo-EM structures of A beta 40 filaments from the leptomeninges of individuals with Alzheimer's disease and cerebral amyloid angiopathy. Acta Neuropathol Commun, 11, 2023
8KH2	Crystal structure of horse-spleen L-ferritin fused with amyloid beta peptide (1-42). Descriptor: CADMIUM ION, CHLORIDE ION, Ferritin light chain,Amyloid-beta precursor protein (Fragment), ... Authors: Maity, B, Tian, J, Abe, S, Ueno, T. Deposit date: 2023-08-21 Release date: 2024-04-03 Last modified: 2024-05-15 Method: X-RAY DIFFRACTION (2 Å) Cite: Fusion of amyloid beta with ferritin yields an isolated oligomeric beta-sheet-rich aggregate inside the ferritin cage. Biomater Sci, 12, 2024
8KF6	The cryo-EM structure of AV-45 bound type3 amyloid beta 42 fibril. Descriptor: P3(40) Authors: Zhao, Q.Y, Tao, Y.Q, Liu, C, Li, D. Deposit date: 2023-08-15 Release date: 2024-08-21 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: The cryo-EM structure of type1 amyloid beta 42 fibril. To Be Published
8KF5	The cryo-EM structure of type1 amyloid beta 42 fibril in AD3. Descriptor: Amyloid-beta precursor protein Authors: Zhao, Q.Y, Tao, Y.Q, Liu, C, Li, D. Deposit date: 2023-08-15 Release date: 2024-08-21 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: The cryo-EM structure of type1 amyloid beta 42 fibril in AD3. To Be Published
8KF3	The cryo-EM structure of type3 amyloid beta 42 fibril. Descriptor: Amyloid-beta precursor protein Authors: Zhao, Q.Y, Tao, Y.Q, Liu, C, Li, D. Deposit date: 2023-08-15 Release date: 2024-08-21 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: The cryo-EM structure of type1 amyloid beta 42 fibril. To Be Published
8KF4	The cryo-EM structure of type1 amyloid beta 42 fibril in AD2 patient. Descriptor: Amyloid-beta precursor protein Authors: Zhao, Q.Y, Tao, Y.Q, Liu, C, Li, D. Deposit date: 2023-08-15 Release date: 2024-08-21 Method: ELECTRON MICROSCOPY (3 Å) Cite: The cryo-EM structure of type1 amyloid beta 42 fibril in AD2 patient. To Be Published
8KF1	The cryo-EM structure of AV-45 bound type1 amyloid beta 42 fibril. Descriptor: 4-[2-[6-[2-[2-(2-fluoranylethoxy)ethoxy]ethoxy]pyridin-3-yl]ethyl]-~{N}-methyl-aniline, P3(40) Authors: Zhao, Q.Y, Tao, Y.Q, Liu, C, Li, D. Deposit date: 2023-08-15 Release date: 2024-08-21 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: The cryo-EM structure of AV-45 bound type1 amyloid beta 42 fibril. To Be Published
8KEW	The cryo-EM structure of type1 amyloid beta 42 fibril. Descriptor: P3(40) Authors: Zhao, Q.Y, Tao, Y.Q, Liu, C, Li, D. Deposit date: 2023-08-13 Release date: 2024-08-14 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: The cryo-EM structure of type1 amyloid beta 42 fibril. To Be Published
8OWJ	Lipidic amyloid-beta(1-40) fibril - polymorph L2-L2 Descriptor: Amyloid-beta A4 protein Authors: Frieg, B, Han, M, Giller, K, Dienemann, C, Riedel, D, Becker, S, Andreas, L.B, Griesinger, C, Schroeder, G.F. Deposit date: 2023-04-28 Release date: 2024-03-06 Method: ELECTRON MICROSCOPY (3.75 Å) Cite: Cryo-EM structures of lipidic fibrils of amyloid-beta (1-40). Nat Commun, 15, 2024
8OWK	Lipidic amyloid-beta(1-40) fibril - polymorph L3-L3 Descriptor: Amyloid-beta A4 protein Authors: Frieg, B, Han, M, Giller, K, Dienemann, C, Riedel, D, Becker, S, Andreas, L.B, Griesinger, C, Schroeder, G.F. Deposit date: 2023-04-28 Release date: 2024-03-06 Method: ELECTRON MICROSCOPY (3.86 Å) Cite: Cryo-EM structures of lipidic fibrils of amyloid-beta (1-40). Nat Commun, 15, 2024
8OWE	Lipidic amyloid-beta(1-40) fibril - polymorph L2-L3 Descriptor: Amyloid-beta A4 protein Authors: Frieg, B, Han, M, Giller, K, Dienemann, C, Riedel, D, Becker, S, Andreas, L.B, Griesinger, C, Schroeder, G.F. Deposit date: 2023-04-27 Release date: 2024-03-06 Method: ELECTRON MICROSCOPY (3.75 Å) Cite: Cryo-EM structures of lipidic fibrils of amyloid-beta (1-40). Nat Commun, 15, 2024
8OWD	Lipidic amyloid-beta(1-40) fibril - polymorph L3 Descriptor: Amyloid-beta A4 protein Authors: Frieg, B, Han, M, Giller, K, Dienemann, C, Riedel, D, Becker, S, Andreas, L.B, Griesinger, C, Schroeder, G.F. Deposit date: 2023-04-27 Release date: 2024-03-06 Method: ELECTRON MICROSCOPY (3.28 Å) Cite: Cryo-EM structures of lipidic fibrils of amyloid-beta (1-40). Nat Commun, 15, 2024
8OVM	Lipidic amyloid-beta(1-40) fibril - polymorph L2 Descriptor: Amyloid-beta A4 protein Authors: Frieg, B, Han, M, Giller, K, Dienemann, C, Riedel, D, Becker, S, Andreas, L.B, Griesinger, C, Schroeder, G.F. Deposit date: 2023-04-26 Release date: 2024-03-06 Method: ELECTRON MICROSCOPY (3.24 Å) Cite: Cryo-EM structures of lipidic fibrils of amyloid-beta (1-40). Nat Commun, 15, 2024
8OVK	Lipidic amyloid-beta(1-40) fibril - polymorph L1 Descriptor: Amyloid-beta A4 protein Authors: Frieg, B, Han, M, Giller, K, Dienemann, C, Riedel, D, Becker, S, Andreas, L.B, Griesinger, C, Schroeder, G.F. Deposit date: 2023-04-26 Release date: 2024-03-06 Method: ELECTRON MICROSCOPY (2.88 Å) Cite: Cryo-EM structures of lipidic fibrils of amyloid-beta (1-40). Nat Commun, 15, 2024
8OT4	seeded Abeta(1-40) amyloid fibril (morphology I) Descriptor: Amyloid-beta A4 protein Authors: Pfeiffer, P.B, Schmidt, M, Faendrich, M. Deposit date: 2023-04-20 Release date: 2024-02-07 Method: ELECTRON MICROSCOPY (2.97 Å) Cite: Cryo-EM Analysis of the Effect of Seeding with Brain-derived A beta Amyloid Fibrils. J.Mol.Biol., 436, 2023
8OTF	Ab typeII filament from Guam ALS/PDC Descriptor: Amyloid-beta precursor protein Authors: Qi, C, Yang, S, Scheres, S.H.W, Goedert, M. Deposit date: 2023-04-20 Release date: 2024-03-27 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Tau filaments from amyotrophic lateral sclerosis/parkinsonism-dementia complex adopt the CTE fold. Proc.Natl.Acad.Sci.USA, 120, 2023
8OT1	unseeded Abeta(1-40) amyloid fibril (morphology i) Descriptor: Amyloid-beta A4 protein Authors: Pfeiffer, P.B, Schmidt, M, Faendrich, M. Deposit date: 2023-04-20 Release date: 2024-02-07 Method: ELECTRON MICROSCOPY (2.59 Å) Cite: Cryo-EM Analysis of the Effect of Seeding with Brain-derived A beta Amyloid Fibrils. J.Mol.Biol., 436, 2023
8OT3	unseeded Abeta(1-40) amyloid fibril (morphology ii) Descriptor: Amyloid-beta A4 protein Authors: Pfeiffer, P.B, Schmidt, M, Faendrich, M. Deposit date: 2023-04-20 Release date: 2024-02-07 Method: ELECTRON MICROSCOPY (2.73 Å) Cite: Cryo-EM Analysis of the Effect of Seeding with Brain-derived A beta Amyloid Fibrils. J.Mol.Biol., 436, 2023
8SEJ	Type I beta-amyloid 42 Filaments from Down syndrome Descriptor: Amyloid-beta protein 42 Authors: Hoq, M.R, Bharath, S.R, Vago, F.S, Jiang, W. Deposit date: 2023-04-10 Release date: 2024-04-03 Last modified: 2024-06-26 Method: ELECTRON MICROSCOPY (3.17 Å) Cite: Cryo-EM structures of amyloid-beta and tau filaments in Down syndrome. Nat.Struct.Mol.Biol., 31, 2024
8SEK	Type IIIa beta-amyloid 40 Filaments from Down syndrome Descriptor: Type IIIb beta-amyloid 40 Filament Authors: Hoq, M.R, Vago, F.S, Bharath, S.R, Jiang, W. Deposit date: 2023-04-10 Release date: 2024-04-03 Last modified: 2024-06-26 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Cryo-EM structures of amyloid-beta and tau filaments in Down syndrome. Nat.Struct.Mol.Biol., 31, 2024
8SEL	Type IIIb beta-amyloid 40 Filaments from Down Syndrome Descriptor: Amyloid-beta protein 40 Authors: Hoq, M.R, Vago, F.S, Bharath, S.R, Jiang, W. Deposit date: 2023-04-10 Release date: 2024-04-03 Last modified: 2024-06-26 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: Cryo-EM structures of amyloid-beta and tau filaments in Down syndrome. Nat.Struct.Mol.Biol., 31, 2024

 

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