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4LND
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BU of 4lnd by Molmil
Crystal structure of human apurinic/apyrimidinic endonuclease 1 with essential Mg2+ cofactor
Descriptor: DNA-(apurinic or apyrimidinic site) lyase, MAGNESIUM ION
Authors:Manvilla, B.A, Pozharski, E, Toth, E.A, Drohat, A.C.
Deposit date:2013-07-11
Release date:2013-11-27
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Structure of human apurinic/apyrimidinic endonuclease 1 with the essential Mg(2+) cofactor.
Acta Crystallogr.,Sect.D, 69, 2013
4CMN
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BU of 4cmn by Molmil
Crystal structure of OCRL in complex with a phosphate ion
Descriptor: GLYCEROL, INOSITOL POLYPHOSPHATE 5-PHOSPHATASE OCRL-1, MAGNESIUM ION, ...
Authors:Tresaugues, L, Moche, M, Arrowsmith, C.H, Berglund, H, Bountra, C, Edwards, A.M, Ekblad, T, Flodin, S, Graslund, S, Karlberg, T, Nyman, T, Schuler, H, Silvander, C, Thorsell, A.G, Weigelt, J, Welin, M, Nordlund, P.
Deposit date:2014-01-16
Release date:2014-04-16
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.13 Å)
Cite:Structural Basis for Phosphoinositide Substrate Recognition, Catalysis, and Membrane Interactions in Human Inositol Polyphosphate 5-Phosphatases.
Structure, 22, 2014
4PUQ
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BU of 4puq by Molmil
Mus Musculus Tdp2 reaction product complex with 5'-phosphorylated RNA/DNA, glycerol, and Mg2+
Descriptor: ACETATE ION, DNA/RNA hybrid, GLYCEROL, ...
Authors:Schellenberg, M.J, Williams, R.S.
Deposit date:2014-03-13
Release date:2014-05-14
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Proteolytic Degradation of Topoisomerase II (Top2) Enables the Processing of Top2DNA and Top2RNA Covalent Complexes by Tyrosyl-DNA-Phosphodiesterase 2 (TDP2).
J.Biol.Chem., 289, 2014
3L1W
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BU of 3l1w by Molmil
The crystal structure of a functionally unknown conserved protein from Enterococcus faecalis V583
Descriptor: 1,2-ETHANEDIOL, FORMIC ACID, SULFATE ION, ...
Authors:Tan, K, Rakowski, E, Jedrzejczak, R, Joachimiak, A, Midwest Center for Structural Genomics (MCSG)
Deposit date:2009-12-14
Release date:2010-01-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The crystal structure of a functionally unknown conserved protein from Enterococcus faecalis V583
To be Published
1I9Y
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BU of 1i9y by Molmil
CRYSTAL STRUCTURE OF INOSITOL POLYPHOSPHATE 5-PHOSPHATASE DOMAIN (IPP5C) OF SPSYNAPTOJANIN
Descriptor: PHOSPHATIDYLINOSITOL PHOSPHATE PHOSPHATASE
Authors:Tsujishita, Y, Guo, S, Stolz, L, York, J.D, Hurley, J.H.
Deposit date:2001-03-21
Release date:2001-05-16
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Specificity determinants in phosphoinositide dephosphorylation: crystal structure of an archetypal inositol polyphosphate 5-phosphatase.
Cell(Cambridge,Mass.), 105, 2001
1I9Z
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BU of 1i9z by Molmil
CRYSTAL STRUCTURE OF INOSITOL POLYPHOSPHATE 5-PHOSPHATASE DOMAIN (IPP5C) OF SPSYNAPTOJANIN IN COMPLEX WITH INOSITOL (1,4)-BISPHOSPHATE AND CALCIUM ION
Descriptor: CALCIUM ION, D-MYO-INOSITOL-1,4-BISPHOSPHATE, PHOSPHATIDYLINOSITOL PHOSPHATE PHOSPHATASE
Authors:Tsujishita, Y, Guo, S, Stolz, L, York, J.D, Hurley, J.H.
Deposit date:2001-03-21
Release date:2001-05-16
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Specificity determinants in phosphoinositide dephosphorylation: crystal structure of an archetypal inositol polyphosphate 5-phosphatase.
Cell(Cambridge,Mass.), 105, 2001
3MPR
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BU of 3mpr by Molmil
Crystal Structure of endonuclease/exonuclease/phosphatase family protein from Bacteroides thetaiotaomicron, Northeast Structural Genomics Consortium Target BtR318A
Descriptor: ACETIC ACID, BROMIDE ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Kuzin, A, Su, M, Seetharaman, J, Mao, M, Xiao, R, Ciccosanti, C, Lee, D, Everett, J.K, Nair, R, Acton, T.B, Rost, B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG)
Deposit date:2010-04-27
Release date:2010-05-26
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (1.899 Å)
Cite:Northeast Structural Genomics Consortium Target BtR318A
To be Published
8IGI
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BU of 8igi by Molmil
Crystal structure of HP1526 (XthA)- a base excision DNA repair protein in Helicobacter pylori
Descriptor: 1,3-BUTANEDIOL, Exodeoxyribonuclease (LexA), MANGANESE (II) ION
Authors:Dinh, T.T, Dao, O, Lee, K.H.
Deposit date:2023-02-20
Release date:2023-12-27
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Crystal structure of the apurinic/apyrimidinic endonuclease XthA (HP1526 protein) from Helicobacter pylori.
Biochem.Biophys.Res.Commun., 663, 2023
2O3C
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BU of 2o3c by Molmil
Crystal structure of zebrafish Ape
Descriptor: APEX nuclease 1, LEAD (II) ION
Authors:Georgiadis, M.M, Gaur, R.K, Delaplane, S, Svenson, J.
Deposit date:2006-12-01
Release date:2007-12-11
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Evolution of the redox function in mammalian apurinic/apyrimidinic endonuclease
Mutat.Res., 643, 2008
8J2F
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BU of 8j2f by Molmil
Human neutral shpingomyelinase
Descriptor: HEPTANE, MAGNESIUM ION, Sphingomyelin phosphodiesterase 2, ...
Authors:Zhang, S.S.
Deposit date:2023-04-14
Release date:2023-12-06
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (3.07 Å)
Cite:Molecular basis for the catalytic mechanism of human neutral sphingomyelinases 1 (hSMPD2).
Nat Commun, 14, 2023
2O3H
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BU of 2o3h by Molmil
Crystal structure of the human C65A Ape
Descriptor: ACETATE ION, DNA-(apurinic or apyrimidinic site) lyase, SAMARIUM (III) ION
Authors:Georgiadis, M.M, Gaur, R.K, Delaplane, S, Svenson, J.
Deposit date:2006-12-01
Release date:2007-12-11
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Evolution of the redox function in mammalian apurinic/apyrimidinic endonuclease
Mutat.Res., 643, 2008
6FK5
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BU of 6fk5 by Molmil
Structure of 3' phosphatase NExo (D146N) from Neisseria bound to DNA substrate in presence of magnesium ion
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, DNA (5'-D(P*CP*TP*AP*GP*CP*GP*AP*AP*GP*CP*TP*AP*GP*A)-3'), MAGNESIUM ION, ...
Authors:Silhan, J, Zhao, Q, Boura, E, Thomson, H, Foster, A, Tang, C.M, Freemont, P.S, Baldwin, G.S.
Deposit date:2018-01-23
Release date:2018-10-31
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Structural basis for recognition and repair of the 3'-phosphate by NExo, a base excision DNA repair nuclease from Neisseria meningitidis.
Nucleic Acids Res., 46, 2018
6FKE
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BU of 6fke by Molmil
Structure of 3' phosphatase NExo (D146N) from Neisseria bound to product DNA hairpin
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, DNA (5'-D(*GP*TP*AP*GP*CP*GP*AP*AP*GP*CP*TP*A)-3'), Exodeoxyribonuclease III, ...
Authors:Silhan, J, Zhao, Q, Boura, E, Thomson, H, Foster, A, Tang, C.M, Freemont, P.S, Baldwin, G.S.
Deposit date:2018-01-23
Release date:2018-10-31
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.151 Å)
Cite:Structural basis for recognition and repair of the 3'-phosphate by NExo, a base excision DNA repair nuclease from Neisseria meningitidis.
Nucleic Acids Res., 46, 2018
6W4T
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BU of 6w4t by Molmil
APE1 Y269A phosphorothioate substrate complex with abasic DNA
Descriptor: DNA (5'-D(*GP*GP*AP*TP*CP*CP*GP*TP*CP*GP*GP*AP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(P*GP*CP*TP*GP*AP*TP*GP*CP*GP*TP*(48Z)P*CP*GP*AP*CP*GP*GP*AP*TP*CP*C)-3'), DNA-(apurinic or apyrimidinic site) lyase
Authors:Freudenthal, B.D, Hoitsma, N.M.
Deposit date:2020-03-11
Release date:2020-06-17
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.77 Å)
Cite:AP-endonuclease 1 sculpts DNA through an anchoring tyrosine residue on the DNA intercalating loop.
Nucleic Acids Res., 48, 2020
1AKO
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BU of 1ako by Molmil
EXONUCLEASE III FROM ESCHERICHIA COLI
Descriptor: EXONUCLEASE III
Authors:Mol, C.D, Kuo, C.-F, Thayer, M.M, Cunningham, R.P, Tainer, J.A.
Deposit date:1997-05-26
Release date:1997-08-20
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure and function of the multifunctional DNA-repair enzyme exonuclease III.
Nature, 374, 1995
6W3N
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BU of 6w3n by Molmil
APE1 exonuclease substrate complex D148E
Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(C7R))-3'), ...
Authors:Freudenthal, B.D, Whitaker, A.M.
Deposit date:2020-03-09
Release date:2020-06-10
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.69 Å)
Cite:Molecular and structural characterization of disease-associated APE1 polymorphisms.
DNA Repair (Amst.), 91-92, 2020
8KA5
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BU of 8ka5 by Molmil
Arabidopsis AP endonuclease ARP complex with 20bp THF-containing DNA
Descriptor: 1',2'-DIDEOXYRIBOFURANOSE-5'-PHOSPHATE, DNA (43-MER), DNA-(apurinic or apyrimidinic site) endonuclease, ...
Authors:Guo, W.T, Wu, B.X.
Deposit date:2023-08-02
Release date:2024-02-21
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural insights into the catalytic mechanism of the AP endonuclease AtARP.
Structure, 32, 2024
8KA3
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BU of 8ka3 by Molmil
Arabidopsis AP endonuclease ARP complex with 22bp THF-containing DNA
Descriptor: 1',2'-DIDEOXYRIBOFURANOSE-5'-PHOSPHATE, DNA (43-MER), DNA-(apurinic or apyrimidinic site) endonuclease, ...
Authors:Guo, W.T, Wu, B.X.
Deposit date:2023-08-02
Release date:2024-02-21
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural insights into the catalytic mechanism of the AP endonuclease AtARP.
Structure, 32, 2024
6W3Q
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BU of 6w3q by Molmil
APE1 exonuclease substrate complex L104R
Descriptor: CALCIUM ION, DNA-(apurinic or apyrimidinic site) lyase, GCTGATGCG(C7R), ...
Authors:Freudenthal, B.D, Whitaker, A.M.
Deposit date:2020-03-09
Release date:2020-06-10
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Molecular and structural characterization of disease-associated APE1 polymorphisms.
DNA Repair (Amst.), 91-92, 2020
8KA4
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BU of 8ka4 by Molmil
Arabidopsis AP endonuclease ARP complex with 21bp THF-containing DNA
Descriptor: 2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE, DNA-(apurinic or apyrimidinic site) endonuclease, chloroplastic, ...
Authors:Guo, W.T, Wu, B.X.
Deposit date:2023-08-02
Release date:2024-02-21
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural insights into the catalytic mechanism of the AP endonuclease AtARP.
Structure, 32, 2024
5J3P
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BU of 5j3p by Molmil
Crystal structure of the catalytic domain of human tyrosyl DNA phosphodiesterase 2
Descriptor: GLYCEROL, MAGNESIUM ION, Tyrosyl-DNA phosphodiesterase 2
Authors:Hornyak, P, Pearl, L.H, Caldecott, K.W, Oliver, A.W.
Deposit date:2016-03-31
Release date:2016-05-04
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2.
Biochem.J., 473, 2016
5J8N
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BU of 5j8n by Molmil
Exonuclease III homologue Mm3148 from Methanosarcina mazei
Descriptor: Exodeoxyribonuclease III, MAGNESIUM ION, TETRAETHYLENE GLYCOL
Authors:Lakomek, K, Dickmanns, A, Ficner, R.
Deposit date:2016-04-08
Release date:2016-04-27
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.44 Å)
Cite:Structure of the archael ExoIII homologue Mm3148 at 1.4 Angstrom
To Be Published
1BIX
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BU of 1bix by Molmil
THE CRYSTAL STRUCTURE OF THE HUMAN DNA REPAIR ENDONUCLEASE HAP1 SUGGESTS THE RECOGNITION OF EXTRA-HELICAL DEOXYRIBOSE AT DNA ABASIC SITES
Descriptor: AP ENDONUCLEASE 1, PLATINUM (II) ION, SAMARIUM (III) ION
Authors:Gorman, M.A, Morera, S, Rothwell, D.G, De La Fortelle, E, Mol, C.D, Tainer, J.A, Hickson, I.D, Freemont, P.S.
Deposit date:1998-06-19
Release date:1999-06-22
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The crystal structure of the human DNA repair endonuclease HAP1 suggests the recognition of extra-helical deoxyribose at DNA abasic sites.
EMBO J., 16, 1997
3TEB
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BU of 3teb by Molmil
endonuclease/exonuclease/phosphatase family protein from Leptotrichia buccalis C-1013-b
Descriptor: Endonuclease/exonuclease/phosphatase, MAGNESIUM ION
Authors:Chang, C, Bigelow, L, Muniez, I, Bearden, J, Joachimiak, A, Midwest Center for Structural Genomics (MCSG)
Deposit date:2011-08-12
Release date:2011-08-31
Method:X-RAY DIFFRACTION (2.99 Å)
Cite:Crystal structure of endonuclease/exonuclease/phosphatase family protein from Leptotrichia buccalis C-1013-b
To be Published
3NGN
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BU of 3ngn by Molmil
Crystal structure of the human CNOT6L nuclease domain in complex with AMP
Descriptor: ADENOSINE MONOPHOSPHATE, CCR4-NOT transcription complex subunit 6-like
Authors:Wang, H, Morita, M, Yang, W, Bartlam, M, Yamamoto, T, Rao, Z.
Deposit date:2010-06-12
Release date:2010-07-28
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of the human CNOT6L nuclease domain reveals strict poly(A) substrate specificity.
Embo J., 2010

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