5J3P
Crystal structure of the catalytic domain of human tyrosyl DNA phosphodiesterase 2
Summary for 5J3P
Entry DOI | 10.2210/pdb5j3p/pdb |
Descriptor | Tyrosyl-DNA phosphodiesterase 2, MAGNESIUM ION, GLYCEROL, ... (4 entities in total) |
Functional Keywords | tyrosyl, dna phosphodiesterase 2, catalytic domain, hydrolase |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus: O95551 |
Total number of polymer chains | 2 |
Total formula weight | 57789.33 |
Authors | Hornyak, P.,Pearl, L.H.,Caldecott, K.W.,Oliver, A.W. (deposition date: 2016-03-31, release date: 2016-05-04, Last modification date: 2024-01-10) |
Primary citation | Hornyak, P.,Askwith, T.,Walker, S.,Komulainen, E.,Paradowski, M.,Pennicott, L.E.,Bartlett, E.J.,Brissett, N.C.,Raoof, A.,Watson, M.,Jordan, A.M.,Ogilvie, D.J.,Ward, S.E.,Atack, J.R.,Pearl, L.H.,Caldecott, K.W.,Oliver, A.W. Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2. Biochem.J., 473:1869-1879, 2016 Cited by PubMed: 27099339DOI: 10.1042/BCJ20160180 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
Download full validation report