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5J3P

Crystal structure of the catalytic domain of human tyrosyl DNA phosphodiesterase 2

Functional Information from GO Data
ChainGOidnamespacecontents
A0003824molecular_functioncatalytic activity
B0003824molecular_functioncatalytic activity
Functional Information from PDB Data
site_idAC1
Number of Residues3
Detailsbinding site for residue MG A 401
ChainResidue
AASP122
AGLU152
AHOH501

site_idAC2
Number of Residues1
Detailsbinding site for residue GOL B 401
ChainResidue
BLEU142

site_idAC3
Number of Residues4
Detailsbinding site for residue MG B 402
ChainResidue
BASP122
BGLU152
BASP350
BHOH501

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton donor/acceptor => ECO:0000305|PubMed:27060144
ChainResidueDetails
AGLY232
BGLY232

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:27099339, ECO:0007744|PDB:5J3P
ChainResidueDetails
AASP122
BASP122

site_idSWS_FT_FI3
Number of Residues8
DetailsSITE: Interaction with 5' end of substrate DNA => ECO:0000250|UniProtKB:Q9JJX7
ChainResidueDetails
AILE148
AASP267
AGLU285
AARG321
BILE148
BASP267
BGLU285
BARG321

226707

PDB entries from 2024-10-30

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