5J3P

Crystal structure of the catalytic domain of human tyrosyl DNA phosphodiesterase 2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
B	0003824	molecular_function	catalytic activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue MG A 401

Chain	Residue
A	ASP122
A	GLU152
A	HOH501

---

site_id	AC2
Number of Residues	1
Details	binding site for residue GOL B 401

Chain	Residue
B	LEU142

---

site_id	AC3
Number of Residues	4
Details	binding site for residue MG B 402

Chain	Residue
B	ASP122
B	GLU152
B	ASP350
B	HOH501

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	17
Details	Region: {"description":"Interaction with 5' end of substrate DNA","evidences":[{"source":"UniProtKB","id":"Q9JJX7","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"27060144","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27099339","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5J3P","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Site: {"description":"Interaction with 5' end of substrate DNA","evidences":[{"source":"UniProtKB","id":"Q9JJX7","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---