5J3P
Crystal structure of the catalytic domain of human tyrosyl DNA phosphodiesterase 2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Tyrosyl-DNA phosphodiesterase 2 | polymer | 253 | 28824.3 | 2 | UniProt (O95551) Pfam (PF03372) | Homo sapiens (Human) | hTDP2,5'-tyrosyl-DNA phosphodiesterase,5'-Tyr-DNA phosphodiesterase,ETS1-associated protein 2,ETS1-associated protein II,EAPII,TRAF and TNF receptor-associated protein,Tyrosyl-RNA phosphodiesterase,VPg unlinkase |
| 2 | C, E (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 3 | D (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 6 | Chemie (HOH) |
Sequence modifications
A, B: 113 - 362 (UniProt: O95551)
| PDB | External Database | Details |
|---|---|---|
| Gly 110 | - | expression tag |
| Ser 111 | - | expression tag |
| His 112 | - | expression tag |
| Ser 273 | Cys 303 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 57648.6 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 140.7 | |
| All* | Total formula weight | 57789.3 |
