4PUQ
Mus Musculus Tdp2 reaction product complex with 5'-phosphorylated RNA/DNA, glycerol, and Mg2+
Summary for 4PUQ
Entry DOI | 10.2210/pdb4puq/pdb |
Related | 4GZ1 |
Descriptor | Tyrosyl-DNA phosphodiesterase 2, DNA/RNA hybrid, MAGNESIUM ION, ... (6 entities in total) |
Functional Keywords | protein-dna complex, dna repair, 5'-dna end processing, eep domain, hydrolase, metalloenzyme, 5'-dna end recognition, hydrolase-dna-rna complex, hydrolase/dna/rna |
Biological source | Mus musculus (mouse) More |
Cellular location | Nucleus (By similarity): Q9JJX7 |
Total number of polymer chains | 4 |
Total formula weight | 63627.85 |
Authors | Schellenberg, M.J.,Williams, R.S. (deposition date: 2014-03-13, release date: 2014-05-14, Last modification date: 2023-09-20) |
Primary citation | Gao, R.,Schellenberg, M.J.,Huang, S.Y.,Abdelmalak, M.,Marchand, C.,Nitiss, K.C.,Nitiss, J.L.,Williams, R.S.,Pommier, Y. Proteolytic Degradation of Topoisomerase II (Top2) Enables the Processing of Top2DNA and Top2RNA Covalent Complexes by Tyrosyl-DNA-Phosphodiesterase 2 (TDP2). J.Biol.Chem., 289:17960-17969, 2014 Cited by PubMed: 24808172DOI: 10.1074/jbc.M114.565374 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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