4PUQ
Mus Musculus Tdp2 reaction product complex with 5'-phosphorylated RNA/DNA, glycerol, and Mg2+
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 401 |
| Chain | Residue |
| A | GLU162 |
| A | HOH612 |
| A | HOH701 |
| A | HOH704 |
| D | C1 |
| D | HOH202 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 401 |
| Chain | Residue |
| B | HOH593 |
| B | HOH594 |
| C | C1 |
| B | GLU162 |
| B | GOL402 |
| B | HOH592 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL B 402 |
| Chain | Residue |
| B | LEU134 |
| B | GLU162 |
| B | ARG216 |
| B | SER239 |
| B | MG401 |
| B | HOH593 |
| B | HOH650 |
| B | HOH703 |
| B | HOH710 |
| C | C1 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL B 403 |
| Chain | Residue |
| A | ASP288 |
| B | PRO300 |
| B | HIS302 |
| B | GLN340 |
| B | SER341 |
| B | LEU342 |
| B | HOH588 |
| B | HOH677 |
| B | HOH686 |
| B | HOH759 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT D 101 |
| Chain | Residue |
| A | LEU315 |
| C | HOH104 |
| D | C1 |
| D | DC2 |
| D | HOH209 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL D 102 |
| Chain | Residue |
| A | GLU242 |
| C | HOH112 |
| C | HOH119 |
| D | C1 |
| D | DC2 |
| D | DG3 |
| D | HOH221 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton donor/acceptor => ECO:0000305|PubMed:23104055, ECO:0000305|PubMed:27060144 |
| Chain | Residue | Details |
| A | ASP272 | |
| B | ASP272 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:23104055, ECO:0000269|PubMed:27099339, ECO:0007744|PDB:4GYZ, ECO:0007744|PDB:4GZ2, ECO:0007744|PDB:5J42 |
| Chain | Residue | Details |
| A | ASP132 | |
| B | ASP132 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:23104055, ECO:0000269|PubMed:24808172, ECO:0000269|PubMed:27099339, ECO:0007744|PDB:4GYZ, ECO:0007744|PDB:4GZ1, ECO:0007744|PDB:4GZ2, ECO:0007744|PDB:4PUQ, ECO:0007744|PDB:5HT2, ECO:0007744|PDB:5INP, ECO:0007744|PDB:5J42 |
| Chain | Residue | Details |
| A | GLU162 | |
| B | GLU162 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | SITE: Interaction with 5' end of substrate DNA => ECO:0000269|PubMed:23104055, ECO:0000269|PubMed:27060144 |
| Chain | Residue | Details |
| A | TYR188 | |
| B | TYR188 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | SITE: Interaction with 5' end of substrate DNA => ECO:0000269|PubMed:23104055, ECO:0000269|PubMed:24808172, ECO:0000269|PubMed:27060144 |
| Chain | Residue | Details |
| A | TRP307 | |
| A | HIS359 | |
| B | TRP307 | |
| B | HIS359 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | SITE: Interaction with 5' end of substrate DNA => ECO:0000269|PubMed:23104055 |
| Chain | Residue | Details |
| A | PHE325 | |
| B | PHE325 |
