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2WRX
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BU of 2wrx by Molmil
Semi-synthetic analogue of human insulin NMeAlaB26-insulin at pH 3.0
Descriptor: INSULIN A CHAIN, INSULIN B CHAIN, SODIUM ION
Authors:Brzozowski, A.M, Jiracek, J, Zakova, L, Antolikova, E, Watson, C.J, Turkenburg, J.P, Dodson, G.G.
Deposit date:2009-09-02
Release date:2010-02-09
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Implications for the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues.
Proc.Natl.Acad.Sci.USA, 107, 2010
2A3G
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BU of 2a3g by Molmil
The structure of T6 bovine insulin
Descriptor: Insulin, ZINC ION
Authors:Smith, G.D, Pangborn, W.A, Blessing, R.H.
Deposit date:2005-06-24
Release date:2005-10-25
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:The structure of T6 bovine insulin.
Acta Crystallogr.,Sect.D, 61, 2005
6P4Z
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BU of 6p4z by Molmil
Structure of gadolinium-caged cobalt (III) insulin hexamer
Descriptor: CHLORIDE ION, COBALT (II) ION, GADOLINIUM ATOM, ...
Authors:Tran, T.H, Taylor, S.K, Stojanovic, M.N, Tong, L.
Deposit date:2019-05-29
Release date:2019-06-12
Last modified:2019-12-18
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Insulin Hexamer-Caged Gadolinium Ion as MRI Contrast-o-phore
ChemBioChem, 24, 2018
3RTO
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BU of 3rto by Molmil
Acoustically mounted porcine insulin microcrystals yield an X-ray SAD structure
Descriptor: Insulin, ZINC ION
Authors:Soares, A.S, Engel, M.A, Stearns, R, Datwani, S, Olechno, J, Ellson, R, Skinner, J.M, Allaire, M, Orville, A.M.
Deposit date:2011-05-03
Release date:2011-05-18
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Acoustically Mounted Microcrystals Yield High-Resolution X-ray Structures.
Biochemistry, 50, 2011
4XC4
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BU of 4xc4 by Molmil
Insulin co-crystallizes in the presence of it beta-cell chaperone sulfatide
Descriptor: CHLORIDE ION, Insulin, SODIUM ION, ...
Authors:Bracey, A.W, Magis, A.T, Buschard, K, Osterbye, T, Bailey, K.M, Ostrov, D.A.
Deposit date:2014-12-17
Release date:2015-02-11
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.499 Å)
Cite:Insulin co-crystallizes in the presence of it beta-cell chaperone sulfatide
To Be Published
1QJ0
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BU of 1qj0 by Molmil
HUMAN INSULIN HEXAMERS WITH CHAIN B HIS MUTATED TO TYR
Descriptor: CHLORIDE ION, INSULIN A CHAIN, INSULIN B CHAIN, ...
Authors:Tang, L, Whittingham, J.L, Verma, C.S, Caves, L.S.D, Dodson, G.G.
Deposit date:1999-06-18
Release date:1999-06-22
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural Consequences of the B5 Histidine --> Tyrosine Mutation in Human Insulin Characterized by X-Ray Crystallography and Conformational Analysis.
Biochemistry, 38, 1999
4CXL
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BU of 4cxl by Molmil
Human insulin analogue (D-ProB8)-insulin
Descriptor: CHLORIDE ION, INSULIN A CHAIN, INSULIN B CHAIN
Authors:Kosinova, L, Veverka, V, Novotna, P, Collinsova, M, Urbanova, M, Jiracek, J, Moody, N.R, Turkenburg, J.P, Brzozowski, A.M, Zakova, L.
Deposit date:2014-04-07
Release date:2014-05-28
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:An Insight Into Structural and Biological Relevance of the T/R Transition of the B-Chain N-Terminus in Human Insulin.
Biochemistry, 53, 2014
1QIY
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BU of 1qiy by Molmil
HUMAN INSULIN HEXAMERS WITH CHAIN B HIS MUTATED TO TYR COMPLEXED WITH PHENOL
Descriptor: CHLORIDE ION, INSULIN A CHAIN, INSULIN B CHAIN, ...
Authors:Tang, L, Whittingham, J.L, Verma, C.S, Caves, L.S.D, Dodson, G.G.
Deposit date:1999-06-18
Release date:1999-06-22
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Consequences of the B5 Histidine --> Tyrosine Mutation in Human Insulin Characterized by X-Ray Crystallography and Conformational Analysis.
Biochemistry, 38, 1999
4CXN
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BU of 4cxn by Molmil
Crystal structure of human insulin analogue (NMe-AlaB8)-insulin crystal form I
Descriptor: INSULIN A CHAIN, INSULIN B CHAIN
Authors:Kosinova, L, Veverka, V, Novotna, P, Collinsova, M, Urbanova, M, Jiracek, J, Moody, N.R, Turkenburg, J.P, Brzozowski, A.M, Zakova, L.
Deposit date:2014-04-07
Release date:2014-05-28
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:An Insight Into Structural and Biological Relevance of the T/R Transition of the B-Chain N-Terminus in Human Insulin.
Biochemistry, 53, 2014
6X4X
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BU of 6x4x by Molmil
B24Y DKP insulin
Descriptor: Insulin, Insulin chain A
Authors:Weiss, M.A, Yang, Y.
Deposit date:2020-05-24
Release date:2020-08-05
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Evolution of insulin at the edge of foldability and its medical implications.
Proc.Natl.Acad.Sci.USA, 117, 2020
9INS
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BU of 9ins by Molmil
MONOVALENT CATION BINDING IN CUBIC INSULIN CRYSTALS
Descriptor: INSULIN (CHAIN A), INSULIN (CHAIN B)
Authors:Badger, J, Dodson, G.G.
Deposit date:1991-10-23
Release date:1991-11-07
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Monovalent cation binding to cubic insulin crystals
Biophys.J., 61, 1992
8Z4B
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BU of 8z4b by Molmil
Crystal structure of LysB22-AspB28 insulin analog at ambient structure
Descriptor: CHLORIDE ION, Insulin A chain, Insulin B chain, ...
Authors:Ayan, E, Demirci, H.
Deposit date:2024-04-17
Release date:2024-05-22
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of LysB22-AspB28 insulin analog at ambient structure
To Be Published
1H02
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BU of 1h02 by Molmil
Human Insulin-like growth factor; SRS Daresbury data
Descriptor: INSULIN-LIKE GROWTH FACTOR I, N-DODECYL-N,N-DIMETHYL-3-AMMONIO-1-PROPANESULFONATE
Authors:Brzozowski, A.M, Dodson, E.J, Dodson, G.G, Murshudov, G, Verma, C, Turkenburg, J.P, De Bree, F.M, Dauter, Z.
Deposit date:2002-06-11
Release date:2002-07-25
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Origins of the Functional Divergence of Human Insulin-Like Growth Factor-I and Insulin
Biochemistry, 41, 2002
3KR3
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BU of 3kr3 by Molmil
Crystal structure of IGF-II antibody complex
Descriptor: 1,2-ETHANEDIOL, Insulin-like growth factor II, antibody-Fab (heavy chain), ...
Authors:Peat, T.S, Newman, J, Adams, T.E.
Deposit date:2009-11-17
Release date:2010-06-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A human monoclonal antibody against insulin-like growth factor-II blocks the growth of human hepatocellular carcinoma cell lines in vitro and in vivo.
Mol.Cancer Ther., 9, 2010
7Z5L
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BU of 7z5l by Molmil
Crystal structure of human insulin, crystallised in the presence of macrophage migration inhibitory factor (MIF) and dimethyl sulfoxide (DMSO)
Descriptor: GLYCEROL, Insulin A chain, Insulin B chain, ...
Authors:van den Elsen, J.M.H, Wahid, A.A, Crennell, C.
Deposit date:2022-03-09
Release date:2023-03-22
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Dissociation of Hexameric Insulin Facilitated by Macrophage Migration Inhibitory Factor Indicates a Novel Role in Insulin Signalling
To Be Published
7Z5Q
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BU of 7z5q by Molmil
Crystal structure of human insulin, crystallised in the presence of macrophage migration inhibitory factor (MIF) and p-Hydroxyphenylpyruvate (HPP)
Descriptor: Insulin, Insulin A chain, SULFATE ION
Authors:van den Elsen, J.M.H, Wahid, A.A, Crennell, S.J.
Deposit date:2022-03-09
Release date:2023-03-22
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Dissociation of Hexameric Insulin Facilitated by Macrophage Migration Inhibitory Factor Indicates a Novel Role in Insulin Signalling
To Be Published
4M4J
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BU of 4m4j by Molmil
Radiation damage study of Cu T6-insulin - 0.30 MGy
Descriptor: COPPER (II) ION, Insulin
Authors:Frankaer, C.G, Harris, P, Stahl, K.
Deposit date:2013-08-07
Release date:2014-01-15
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Towards accurate structural characterization of metal centres in protein crystals: the structures of Ni and Cu T6 bovine insulin derivatives.
Acta Crystallogr.,Sect.D, 70, 2014
4M4F
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BU of 4m4f by Molmil
Radiation damage study of Cu T6-insulin - 0.01 MGy
Descriptor: COPPER (II) ION, Insulin
Authors:Frankaer, C.G, Harris, P, Stahl, K.
Deposit date:2013-08-07
Release date:2014-01-15
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Towards accurate structural characterization of metal centres in protein crystals: the structures of Ni and Cu T6 bovine insulin derivatives.
Acta Crystallogr.,Sect.D, 70, 2014
4M4M
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BU of 4m4m by Molmil
The structure of Ni T6 bovine insulin
Descriptor: Insulin, NICKEL (II) ION
Authors:Frankaer, C.G, Harris, P, Stahl, K.
Deposit date:2013-08-07
Release date:2014-01-15
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Towards accurate structural characterization of metal centres in protein crystals: the structures of Ni and Cu T6 bovine insulin derivatives.
Acta Crystallogr.,Sect.D, 70, 2014
3KQ6
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BU of 3kq6 by Molmil
Enhancing the Therapeutic Properties of a Protein by a Designed Zinc-Binding Site, Structural principles of a novel long-acting insulin analog
Descriptor: CHLORIDE ION, Insulin A chain, Insulin B chain, ...
Authors:Wan, Z.L, Hu, S.Q, Whittaker, L, Phillips, N.B, Whittake, J, Ismail-Beigi, F, Weiss, M.A.
Deposit date:2009-11-17
Release date:2010-02-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Supramolecular protein engineering: design of zinc-stapled insulin hexamers as a long acting depot.
J.Biol.Chem., 285, 2010
1HIT
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BU of 1hit by Molmil
Receptor binding redefined by a structural switch in a mutant Human Insulin
Descriptor: INSULIN
Authors:Hua, Q.X, Kochoyan, M, Weiss, M.A.
Deposit date:1992-02-28
Release date:1994-01-31
Last modified:2024-06-05
Method:SOLUTION NMR
Cite:Receptor binding redefined by a structural switch in a mutant human insulin.
Nature, 354, 1991
6O17
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BU of 6o17 by Molmil
Recombinant Human Insulin
Descriptor: Insulin chain A, Insulin chain B
Authors:Reyes-Grajeda, J.P.
Deposit date:2019-02-18
Release date:2020-02-26
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Human WT insulin
To Be Published
6NWV
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BU of 6nwv by Molmil
Insulin Lispro Analog
Descriptor: CHLORIDE ION, GLYCEROL, Insulin A chain, ...
Authors:Cruz-Rangel, A, Romero, A, Reyes-Grajeda, J.P.
Deposit date:2019-02-07
Release date:2020-02-12
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.601 Å)
Cite:Crystal structure of Lispro hexameric insulin analog
To Be Published
3LRI
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BU of 3lri by Molmil
Solution structure and backbone dynamics of long-[Arg(3)]insulin-like growth factor-I
Descriptor: PROTEIN (INSULIN-LIKE GROWTH FACTOR I)
Authors:Laajoki, L.G, Francis, G.L, Wallace, J.C, Carver, J.A, Keniry, M.A.
Deposit date:1999-04-13
Release date:2000-05-23
Last modified:2023-12-27
Method:SOLUTION NMR
Cite:Solution structure and backbone dynamics of long-[Arg(3)]insulin-like growth factor-I
J.Biol.Chem., 275, 2000
7INS
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BU of 7ins by Molmil
STRUCTURE OF PORCINE INSULIN COCRYSTALLIZED WITH CLUPEINE Z
Descriptor: GENERAL PROTAMINE CHAIN, INSULIN (CHAIN A), INSULIN (CHAIN B), ...
Authors:Balschmidt, P, Hansen, F.B, Dodson, E, Dodson, G, Korber, F.
Deposit date:1991-09-03
Release date:1994-01-31
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of porcine insulin cocrystallized with clupeine Z.
Acta Crystallogr.,Sect.B, 47, 1991

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