5ZQU
Crystal structure of tetrameric RXRalpha-LBD complexed with partial agonist CBt-PMN
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003707 | molecular_function | nuclear steroid receptor activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0008270 | molecular_function | zinc ion binding |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003707 | molecular_function | nuclear steroid receptor activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0008270 | molecular_function | zinc ion binding |
| C | 0003677 | molecular_function | DNA binding |
| C | 0003707 | molecular_function | nuclear steroid receptor activity |
| C | 0005634 | cellular_component | nucleus |
| C | 0006355 | biological_process | regulation of DNA-templated transcription |
| C | 0008270 | molecular_function | zinc ion binding |
| D | 0003677 | molecular_function | DNA binding |
| D | 0003707 | molecular_function | nuclear steroid receptor activity |
| D | 0005634 | cellular_component | nucleus |
| D | 0006355 | biological_process | regulation of DNA-templated transcription |
| D | 0008270 | molecular_function | zinc ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | binding site for residue 9HF A 501 |
| Chain | Residue |
| A | ALA272 |
| A | 9HF502 |
| A | GLN275 |
| A | TRP305 |
| A | ASN306 |
| A | LEU309 |
| A | ARG316 |
| A | LEU326 |
| A | ALA327 |
| A | PHE438 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue 9HF A 502 |
| Chain | Residue |
| A | ALA272 |
| A | TRP305 |
| A | LEU433 |
| A | PHE439 |
| A | 9HF501 |
| C | LEU436 |
| C | PHE439 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue BR A 503 |
| Chain | Residue |
| A | ARG393 |
| A | HOH610 |
| B | ARG421 |
| B | HOH606 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue BR A 504 |
| Chain | Residue |
| A | ARG421 |
| B | ARG393 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | binding site for residue BR A 506 |
| Chain | Residue |
| A | ARG348 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | binding site for residue 9HF B 501 |
| Chain | Residue |
| B | ILE268 |
| B | ALA272 |
| B | GLN275 |
| B | TRP305 |
| B | LEU309 |
| B | LEU326 |
| B | ALA327 |
| B | PHE438 |
| B | PHE439 |
| site_id | AC7 |
| Number of Residues | 1 |
| Details | binding site for residue BR B 502 |
| Chain | Residue |
| B | ARG371 |
| site_id | AC8 |
| Number of Residues | 1 |
| Details | binding site for residue BR B 503 |
| Chain | Residue |
| B | ARG348 |
| site_id | AC9 |
| Number of Residues | 1 |
| Details | binding site for residue BR B 504 |
| Chain | Residue |
| B | ARG371 |
| site_id | AD1 |
| Number of Residues | 10 |
| Details | binding site for residue 9HF C 501 |
| Chain | Residue |
| C | ILE268 |
| C | ALA271 |
| C | ALA272 |
| C | GLN275 |
| C | TRP305 |
| C | LEU309 |
| C | ARG316 |
| C | LEU326 |
| C | ALA327 |
| C | PHE439 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for residue BR C 502 |
| Chain | Residue |
| C | ARG393 |
| D | ARG421 |
| D | HOH605 |
| site_id | AD3 |
| Number of Residues | 2 |
| Details | binding site for residue BR C 503 |
| Chain | Residue |
| C | ARG348 |
| C | LYS431 |
| site_id | AD4 |
| Number of Residues | 11 |
| Details | binding site for residue 9HF D 501 |
| Chain | Residue |
| D | ALA272 |
| D | GLN275 |
| D | TRP305 |
| D | ASN306 |
| D | LEU309 |
| D | PHE313 |
| D | ARG316 |
| D | LEU326 |
| D | ALA327 |
| D | PHE438 |
| D | 9HF502 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for residue 9HF D 502 |
| Chain | Residue |
| B | LEU436 |
| B | PHE439 |
| D | LEU433 |
| D | PHE438 |
| D | PHE439 |
| D | 9HF501 |
| site_id | AD6 |
| Number of Residues | 2 |
| Details | binding site for residue BR D 503 |
| Chain | Residue |
| C | ARG421 |
| D | ARG393 |
| site_id | AD7 |
| Number of Residues | 1 |
| Details | binding site for residue BR D 504 |
| Chain | Residue |
| D | ARG348 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16107141, ECO:0000269|PubMed:18800767, ECO:0000269|PubMed:19167885, ECO:0007744|PDB:2ACL, ECO:0007744|PDB:3FAL, ECO:0007744|PDB:3FC6 |
| Chain | Residue | Details |
| A | ARG316 | |
| A | ALA327 | |
| B | ARG316 | |
| B | ALA327 | |
| C | ARG316 | |
| C | ALA327 | |
| D | ARG316 | |
| D | ALA327 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER259 | |
| B | SER259 | |
| C | SER259 | |
| D | SER259 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine; by MAPK8 and MAPK9 => ECO:0000250|UniProtKB:P28700 |
| Chain | Residue | Details |
| A | SER260 | |
| B | SER260 | |
| C | SER260 | |
| D | SER260 |
