3FC6

hRXRalpha & mLXRalpha with an indole Pharmacophore, SB786875

Summary for 3FC6

Entry DOI	10.2210/pdb3fc6/pdb
Descriptor	Retinoic acid receptor RXR-alpha, Nr1h3 protein, RETINOIC ACID, ... (5 entities in total)
Functional Keywords	liver x receptor, nuclear hormone receptors, agonists, epoxycholesterol, dna-binding, host-virus interaction, metal-binding, nucleus, polymorphism, receptor, transcription, transcription regulation, ubl conjugation, zinc, zinc-finger
Biological source	Homo sapiens (human) More
Cellular location	Nucleus: P19793
Total number of polymer chains	4
Total formula weight	117308.05
Authors	Washburn, D.G.,Hoang, T.H.,Campobasso, N.,Smallwood, A.,Parks, D.J.,Webb, C.L.,Frank, K.,Nord, M.,Duraiswami, C.,Evans, C.,Jaye, M.,Thompson, S.K. (deposition date: 2008-11-21, release date: 2009-02-10, Last modification date: 2023-12-27)
Primary citation	Washburn, D.G.,Hoang, T.H.,Campobasso, N.,Smallwood, A.,Parks, D.J.,Webb, C.L.,Frank, K.A.,Nord, M.,Duraiswami, C.,Evans, C.,Jaye, M.,Thompson, S.K. Synthesis and SAR of potent LXR agonists containing an indole pharmacophore. Bioorg.Med.Chem.Lett., 19:1097-1100, 2009 Cited by PubMed: 19167885 DOI: 10.1016/j.bmcl.2009.01.004 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.063 Å)

Structure validation