3FC6
hRXRalpha & mLXRalpha with an indole Pharmacophore, SB786875
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Retinoic acid receptor RXR-alpha | polymer | 242 | 27114.5 | 2 | UniProt (P19793) Pfam (PF00104) | Homo sapiens (human) | Retinoid X receptor alpha, Nuclear receptor subfamily 2 group B member 1 |
| 2 | B, D (B, D) | Nr1h3 protein | polymer | 266 | 30618.0 | 2 | UniProt (Q91X41) Pfam (PF00104) UniProt (by SIFTS) (Q9Z0Y9) | Mus musculus (mouse) | Putative uncharacterized protein, Nuclear receptor subfamily 1 group H member 3, Nuclear receptor subfamily 1, group H, member 3, Nuclear receptor subfamily 1, group H, member 3, isoform CRA_a |
| 3 | E, G (A, C) | RETINOIC ACID | non-polymer | 300.4 | 2 | Chemie (REA) PubChem (5538) PubChem (23275881) PubChem (25145416) PubChem (444795) PubChem (449171) PubChem (5282379) PubChem (6336207) PubChem (6336229) PubChem (6419708) PubChem (87179195) PubChem (87519764) PubChem (87980058) PubChem (88439848) PubChem (88525859) PubChem (88604688) PubChem (6603983) PubChem (9796370) PubChem (9861147) PubChem (445925) PubChem (10881132) PubChem (12358677) PubChem (12358678) PubChem (12358679) PubChem (12358681) PubChem (134688661) PubChem (139597075) PubChem (145826768) PubChem (166478803) | |||
| 4 | F, H (B, D) | [4-(3-{[2-chloro-3-(trifluoromethyl)benzyl](2,2-diphenylethyl)amino}propoxy)-1H-indol-1-yl]acetic acid | non-polymer | 621.1 | 2 | Chemie (LX2) PubChem (25147499) | |||
| 5 | I, J, K, L (A, B, C, D) | water | water | 18.0 | 229 | Chemie (HOH) |
Sequence modifications
A, C: 225 - 462 (UniProt: P19793)
B, D: 200 - 445 (UniProt: Q91X41)
| PDB | External Database | Details |
|---|---|---|
| Met 221 | - | expression tag |
| Lys 222 | - | expression tag |
| Lys 223 | - | expression tag |
| Gly 224 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 180 | - | expression tag |
| Arg 181 | - | expression tag |
| Gly 182 | - | expression tag |
| Ser 183 | - | expression tag |
| His 184 | - | expression tag |
| His 185 | - | expression tag |
| His 186 | - | expression tag |
| His 187 | - | expression tag |
| His 188 | - | expression tag |
| His 189 | - | expression tag |
| Gly 190 | - | expression tag |
| Met 191 | - | expression tag |
| Ala 192 | - | expression tag |
| Ser 193 | - | expression tag |
| Leu 194 | - | expression tag |
| Val 195 | - | expression tag |
| Pro 196 | - | expression tag |
| Arg 197 | - | expression tag |
| Gly 198 | - | expression tag |
| Ser 199 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 115465.0 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1843.0 | |
| All* | Total formula weight | 117308.0 |
