3FC6
hRXRalpha & mLXRalpha with an indole Pharmacophore, SB786875
Summary for 3FC6
Entry DOI | 10.2210/pdb3fc6/pdb |
Descriptor | Retinoic acid receptor RXR-alpha, Nr1h3 protein, RETINOIC ACID, ... (5 entities in total) |
Functional Keywords | liver x receptor, nuclear hormone receptors, agonists, epoxycholesterol, dna-binding, host-virus interaction, metal-binding, nucleus, polymorphism, receptor, transcription, transcription regulation, ubl conjugation, zinc, zinc-finger |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus: P19793 |
Total number of polymer chains | 4 |
Total formula weight | 117308.05 |
Authors | Washburn, D.G.,Hoang, T.H.,Campobasso, N.,Smallwood, A.,Parks, D.J.,Webb, C.L.,Frank, K.,Nord, M.,Duraiswami, C.,Evans, C.,Jaye, M.,Thompson, S.K. (deposition date: 2008-11-21, release date: 2009-02-10, Last modification date: 2023-12-27) |
Primary citation | Washburn, D.G.,Hoang, T.H.,Campobasso, N.,Smallwood, A.,Parks, D.J.,Webb, C.L.,Frank, K.A.,Nord, M.,Duraiswami, C.,Evans, C.,Jaye, M.,Thompson, S.K. Synthesis and SAR of potent LXR agonists containing an indole pharmacophore. Bioorg.Med.Chem.Lett., 19:1097-1100, 2009 Cited by PubMed: 19167885DOI: 10.1016/j.bmcl.2009.01.004 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.063 Å) |
Structure validation
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