5ZQU

Crystal structure of tetrameric RXRalpha-LBD complexed with partial agonist CBt-PMN

Summary for 5ZQU

• Entry DOI: 10.2210/pdb5zqu/pdb
• Descriptor: Retinoic acid receptor RXR-alpha, 1-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)benzotriazole-5-carboxylic acid, BROMIDE ION, ... (4 entities in total)
• Functional Keywords: extended form, multiple conformation, nuclear receptor, retinoid x receptor, transcription
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 111556.83

Authors

Miyashita, Y.,Numoto, N.,Arulmozhiraja, S.,Nakano, S.,Matsuo, N.,Shimizu, K.,Kakuta, H.,Ito, S.,Ikura, T.,Ito, N.,Tokiwa, H. (deposition date: 2018-04-20, release date: 2019-02-27, Last modification date: 2023-11-22)

• Primary citation: Miyashita, Y.,Numoto, N.,Arulmozhiraja, S.,Nakano, S.,Matsuo, N.,Shimizu, K.,Shibahara, O.,Fujihara, M.,Kakuta, H.,Ito, S.,Ikura, T.,Ito, N.,Tokiwa, H.; Dual conformation of the ligand induces the partial agonistic activity of retinoid X receptor alpha (RXR alpha ).; FEBS Lett., 593:242-250, 2019; PubMed: 30565665; DOI: 10.1002/1873-3468.13301

Experimental method

X-RAY DIFFRACTION (2.60038789589 Å)