3FAL

humanRXR alpha & mouse LXR alpha complexed with Retenoic acid and GSK2186

Summary for 3FAL

Entry DOI	10.2210/pdb3fal/pdb
Descriptor	Retinoic acid receptor RXR-alpha, Oxysterols receptor LXR-alpha, RETINOIC ACID, ... (5 entities in total)
Functional Keywords	nuclear hormone receptor nonsteroidal lxr agonist choloestorol metabolism, dna-binding, host-virus interaction, metal-binding, nucleus, polymorphism, receptor, transcription, transcription regulation, ubl conjugation, zinc, zinc-finger, signaling protein
Biological source	Homo sapiens (human) More
Cellular location	Nucleus: P19793 Nucleus (Potential): Q9Z0Y9
Total number of polymer chains	4
Total formula weight	117065.62
Authors	Chao, E.Y.,Caravella, J.A.,Watson, M.A.,Campobasso, N.,Ghisletti, S.,Billin, A.N.,Galardi, C.,Willson, T.M.,Zuercher, W.J.,Collins, J.L. (deposition date: 2008-11-17, release date: 2009-04-14, Last modification date: 2023-12-27)
Primary citation	Chao, E.Y.,Caravella, J.A.,Watson, M.A.,Campobasso, N.,Ghisletti, S.,Billin, A.N.,Galardi, C.,Wang, P.,Laffitte, B.A.,Iannone, M.A.,Goodwin, B.J.,Nichols, J.A.,Parks, D.J.,Stewart, E.,Wiethe, R.W.,Williams, S.P.,Smallwood, A.,Pearce, K.H.,Glass, C.K.,Willson, T.M.,Zuercher, W.J.,Collins, J.L. Structure-guided design of N-phenyl tertiary amines as transrepression-selective liver X receptor modulators with anti-inflammatory activity. J.Med.Chem., 51:5758-5765, 2008 Cited by PubMed: 18800767 DOI: 10.1021/jm800612u PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.36 Å)

Structure validation