3FAL

humanRXR alpha & mouse LXR alpha complexed with Retenoic acid and GSK2186

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Retinoic acid receptor RXR-alpha	polymer	242	27114.5	2	UniProt (P19793) Pfam (PF00104)	Homo sapiens (human)	Retinoid X receptor alpha, Nuclear receptor subfamily 2 group B member 1
2	B, D (B, D)	Oxysterols receptor LXR-alpha	polymer	266	30618.0	2	UniProt (Q9Z0Y9) Pfam (PF00104)	Mus musculus (mouse)	Liver X receptor alpha, Nuclear orphan receptor LXR-alpha, Nuclear receptor subfamily 1 group H member 3
3	E, G (A, C)	RETINOIC ACID	non-polymer		300.4	2	Chemie (REA)
4	F, H (B, D)	2-{4-[butyl(3-chloro-4,5-dimethoxybenzyl)amino]phenyl}-1,1,1,3,3,3-hexafluoropropan-2-ol	non-polymer		499.9	2	Chemie (LO2)
5	I, J, K (B, C, D)	water	water		18.0	16	Chemie (HOH)

Sequence modifications

A, C: 225 - 463 (UniProt: P19793)

PDB	External Database	Details
Met 221	-	expression tag
Lys 222	-	expression tag
Lys 223	-	expression tag
Gly 224	-	expression tag

B, D: 200 - 445 (UniProt: Q9Z0Y9)

PDB	External Database	Details
Met 180	-	expression tag
Arg 181	-	expression tag
Gly 182	-	expression tag
Ser 183	-	expression tag
His 184	-	expression tag
His 185	-	expression tag
His 186	-	expression tag
His 187	-	expression tag
His 188	-	expression tag
His 189	-	expression tag
Gly 190	-	expression tag
Met 191	-	expression tag
Ala 192	-	expression tag
Ser 193	-	expression tag
Leu 194	-	expression tag
Val 195	-	expression tag
Pro 196	-	expression tag
Arg 197	-	expression tag
Gly 198	-	expression tag
Ser 199	-	expression tag
Pro 399	Arg 399	SEE REMARK 999

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	115465.0
Non-Polymers*	Number of molecules	4
	Total formula weight	1600.6
All*	Total formula weight	117065.6

*Water molecules are not included.