3FAL
humanRXR alpha & mouse LXR alpha complexed with Retenoic acid and GSK2186
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003707 | molecular_function | nuclear steroid receptor activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0008270 | molecular_function | zinc ion binding |
| B | 0003677 | molecular_function | DNA binding |
| B | 0004879 | molecular_function | nuclear receptor activity |
| B | 0006629 | biological_process | lipid metabolic process |
| C | 0003677 | molecular_function | DNA binding |
| C | 0003707 | molecular_function | nuclear steroid receptor activity |
| C | 0005634 | cellular_component | nucleus |
| C | 0006355 | biological_process | regulation of DNA-templated transcription |
| C | 0008270 | molecular_function | zinc ion binding |
| D | 0003677 | molecular_function | DNA binding |
| D | 0004879 | molecular_function | nuclear receptor activity |
| D | 0006629 | biological_process | lipid metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE REA A 501 |
| Chain | Residue |
| A | ILE268 |
| A | ALA271 |
| A | GLN275 |
| A | PHE313 |
| A | ARG316 |
| A | ALA327 |
| A | ILE345 |
| A | CYS432 |
| site_id | AC2 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE LO2 B 1 |
| Chain | Residue |
| B | THR256 |
| B | LEU258 |
| B | ALA259 |
| B | SER262 |
| B | MET296 |
| B | GLU299 |
| B | THR300 |
| B | PHE313 |
| B | PHE324 |
| B | LEU329 |
| B | PHE338 |
| B | HIS419 |
| B | GLN422 |
| B | LEU426 |
| B | LEU433 |
| B | TRP441 |
| B | PHE255 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE REA C 501 |
| Chain | Residue |
| C | ALA271 |
| C | ALA272 |
| C | GLN275 |
| C | PHE313 |
| C | ARG316 |
| C | LEU326 |
| C | ALA327 |
| C | CYS432 |
| site_id | AC4 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE LO2 D 1 |
| Chain | Residue |
| D | PHE255 |
| D | THR256 |
| D | LEU258 |
| D | ALA259 |
| D | SER262 |
| D | MET296 |
| D | LEU297 |
| D | GLU299 |
| D | THR300 |
| D | PHE313 |
| D | PHE324 |
| D | LEU329 |
| D | HIS419 |
| D | GLN422 |
| D | LEU426 |
| D | LEU433 |
| D | TRP441 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 40 |
| Details | Region: {"description":"Required for nuclear export","evidences":[{"source":"PubMed","id":"15509776","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16107141","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18800767","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19167885","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2ACL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FAL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FC6","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
