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5FYQ

Sirt2 in complex with a 13-mer trifluoroacetylated Ran peptide

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0000183biological_processrDNA heterochromatin formation
A0000781cellular_componentchromosome, telomeric region
A0000792cellular_componentheterochromatin
A0003682molecular_functionchromatin binding
A0003950molecular_functionNAD+ ADP-ribosyltransferase activity
A0004407molecular_functionhistone deacetylase activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005677cellular_componentchromatin silencing complex
A0005694cellular_componentchromosome
A0005730cellular_componentnucleolus
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005813cellular_componentcentrosome
A0005814cellular_componentcentriole
A0005819cellular_componentspindle
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005874cellular_componentmicrotubule
A0005886cellular_componentplasma membrane
A0006325biological_processchromatin organization
A0006476biological_processprotein deacetylation
A0006914biological_processautophagy
A0007084biological_processmitotic nuclear membrane reassembly
A0007096biological_processregulation of exit from mitosis
A0007399biological_processnervous system development
A0008270molecular_functionzinc ion binding
A0010507biological_processnegative regulation of autophagy
A0010801biological_processnegative regulation of peptidyl-threonine phosphorylation
A0016740molecular_functiontransferase activity
A0017136molecular_functionNAD-dependent histone deacetylase activity
A0021762biological_processsubstantia nigra development
A0022011biological_processmyelination in peripheral nervous system
A0030154biological_processcell differentiation
A0030426cellular_componentgrowth cone
A0030496cellular_componentmidbody
A0031507biological_processheterochromatin formation
A0031509biological_processsubtelomeric heterochromatin formation
A0031641biological_processregulation of myelination
A0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
A0033010cellular_componentparanodal junction
A0033270cellular_componentparanode region of axon
A0033558molecular_functionprotein lysine deacetylase activity
A0034599biological_processcellular response to oxidative stress
A0034979molecular_functionNAD-dependent protein lysine deacetylase activity
A0034983biological_processpeptidyl-lysine deacetylation
A0035035molecular_functionhistone acetyltransferase binding
A0040029biological_processepigenetic regulation of gene expression
A0042177biological_processnegative regulation of protein catabolic process
A0042325biological_processregulation of phosphorylation
A0042826molecular_functionhistone deacetylase binding
A0042903molecular_functiontubulin deacetylase activity
A0042995cellular_componentcell projection
A0043130molecular_functionubiquitin binding
A0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
A0043204cellular_componentperikaryon
A0043209cellular_componentmyelin sheath
A0043219cellular_componentlateral loop
A0043220cellular_componentSchmidt-Lanterman incisure
A0043388biological_processpositive regulation of DNA binding
A0043687biological_processpost-translational protein modification
A0044224cellular_componentjuxtaparanode region of axon
A0044242biological_processcellular lipid catabolic process
A0044546biological_processNLRP3 inflammasome complex assembly
A0045087biological_processinnate immune response
A0045598biological_processregulation of fat cell differentiation
A0045599biological_processnegative regulation of fat cell differentiation
A0045723biological_processpositive regulation of fatty acid biosynthetic process
A0045836biological_processpositive regulation of meiotic nuclear division
A0045843biological_processnegative regulation of striated muscle tissue development
A0045892biological_processnegative regulation of DNA-templated transcription
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0046872molecular_functionmetal ion binding
A0046970molecular_functionNAD-dependent histone H4K16 deacetylase activity
A0048471cellular_componentperinuclear region of cytoplasm
A0051287molecular_functionNAD binding
A0051301biological_processcell division
A0051321biological_processmeiotic cell cycle
A0051726biological_processregulation of cell cycle
A0051775biological_processresponse to redox state
A0051781biological_processpositive regulation of cell division
A0051987biological_processpositive regulation of attachment of spindle microtubules to kinetochore
A0061433biological_processcellular response to caloric restriction
A0070403molecular_functionNAD+ binding
A0070446biological_processnegative regulation of oligodendrocyte progenitor proliferation
A0071456biological_processcellular response to hypoxia
A0071872biological_processcellular response to epinephrine stimulus
A0072686cellular_componentmitotic spindle
A0072687cellular_componentmeiotic spindle
A0090042biological_processtubulin deacetylation
A0097386cellular_componentglial cell projection
A0140297molecular_functionDNA-binding transcription factor binding
A0140773molecular_functionNAD-dependent protein demyristoylase activity
A0140774molecular_functionNAD-dependent protein depalmitoylase activity
A1900119biological_processpositive regulation of execution phase of apoptosis
A1900195biological_processpositive regulation of oocyte maturation
A1900226biological_processnegative regulation of NLRP3 inflammasome complex assembly
A1902725biological_processnegative regulation of satellite cell differentiation
A1990404molecular_functionNAD+-protein ADP-ribosyltransferase activity
A2000378biological_processnegative regulation of reactive oxygen species metabolic process
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0000183biological_processrDNA heterochromatin formation
B0000781cellular_componentchromosome, telomeric region
B0000792cellular_componentheterochromatin
B0003682molecular_functionchromatin binding
B0003950molecular_functionNAD+ ADP-ribosyltransferase activity
B0004407molecular_functionhistone deacetylase activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005677cellular_componentchromatin silencing complex
B0005694cellular_componentchromosome
B0005730cellular_componentnucleolus
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005813cellular_componentcentrosome
B0005814cellular_componentcentriole
B0005819cellular_componentspindle
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005874cellular_componentmicrotubule
B0005886cellular_componentplasma membrane
B0006325biological_processchromatin organization
B0006476biological_processprotein deacetylation
B0006914biological_processautophagy
B0007084biological_processmitotic nuclear membrane reassembly
B0007096biological_processregulation of exit from mitosis
B0007399biological_processnervous system development
B0008270molecular_functionzinc ion binding
B0010507biological_processnegative regulation of autophagy
B0010801biological_processnegative regulation of peptidyl-threonine phosphorylation
B0016740molecular_functiontransferase activity
B0017136molecular_functionNAD-dependent histone deacetylase activity
B0021762biological_processsubstantia nigra development
B0022011biological_processmyelination in peripheral nervous system
B0030154biological_processcell differentiation
B0030426cellular_componentgrowth cone
B0030496cellular_componentmidbody
B0031507biological_processheterochromatin formation
B0031509biological_processsubtelomeric heterochromatin formation
B0031641biological_processregulation of myelination
B0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
B0033010cellular_componentparanodal junction
B0033270cellular_componentparanode region of axon
B0033558molecular_functionprotein lysine deacetylase activity
B0034599biological_processcellular response to oxidative stress
B0034979molecular_functionNAD-dependent protein lysine deacetylase activity
B0034983biological_processpeptidyl-lysine deacetylation
B0035035molecular_functionhistone acetyltransferase binding
B0040029biological_processepigenetic regulation of gene expression
B0042177biological_processnegative regulation of protein catabolic process
B0042325biological_processregulation of phosphorylation
B0042826molecular_functionhistone deacetylase binding
B0042903molecular_functiontubulin deacetylase activity
B0042995cellular_componentcell projection
B0043130molecular_functionubiquitin binding
B0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
B0043204cellular_componentperikaryon
B0043209cellular_componentmyelin sheath
B0043219cellular_componentlateral loop
B0043220cellular_componentSchmidt-Lanterman incisure
B0043388biological_processpositive regulation of DNA binding
B0043687biological_processpost-translational protein modification
B0044224cellular_componentjuxtaparanode region of axon
B0044242biological_processcellular lipid catabolic process
B0044546biological_processNLRP3 inflammasome complex assembly
B0045087biological_processinnate immune response
B0045598biological_processregulation of fat cell differentiation
B0045599biological_processnegative regulation of fat cell differentiation
B0045723biological_processpositive regulation of fatty acid biosynthetic process
B0045836biological_processpositive regulation of meiotic nuclear division
B0045843biological_processnegative regulation of striated muscle tissue development
B0045892biological_processnegative regulation of DNA-templated transcription
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0046872molecular_functionmetal ion binding
B0046970molecular_functionNAD-dependent histone H4K16 deacetylase activity
B0048471cellular_componentperinuclear region of cytoplasm
B0051287molecular_functionNAD binding
B0051301biological_processcell division
B0051321biological_processmeiotic cell cycle
B0051726biological_processregulation of cell cycle
B0051775biological_processresponse to redox state
B0051781biological_processpositive regulation of cell division
B0051987biological_processpositive regulation of attachment of spindle microtubules to kinetochore
B0061433biological_processcellular response to caloric restriction
B0070403molecular_functionNAD+ binding
B0070446biological_processnegative regulation of oligodendrocyte progenitor proliferation
B0071456biological_processcellular response to hypoxia
B0071872biological_processcellular response to epinephrine stimulus
B0072686cellular_componentmitotic spindle
B0072687cellular_componentmeiotic spindle
B0090042biological_processtubulin deacetylation
B0097386cellular_componentglial cell projection
B0140297molecular_functionDNA-binding transcription factor binding
B0140773molecular_functionNAD-dependent protein demyristoylase activity
B0140774molecular_functionNAD-dependent protein depalmitoylase activity
B1900119biological_processpositive regulation of execution phase of apoptosis
B1900195biological_processpositive regulation of oocyte maturation
B1900226biological_processnegative regulation of NLRP3 inflammasome complex assembly
B1902725biological_processnegative regulation of satellite cell differentiation
B1990404molecular_functionNAD+-protein ADP-ribosyltransferase activity
B2000378biological_processnegative regulation of reactive oxygen species metabolic process
Functional Information from PDB Data
site_idAC1
Number of Residues8
DetailsBINDING SITE FOR RESIDUE SO4 B 1357
ChainResidue
BGLY84
BALA85
BASP95
BARG97
BGLY261
BTHR262
BSER263
BGLN265

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 A 1357
ChainResidue
AGLN167
ATHR262
ASER263
ALEU264
AARG97

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B 1358
ChainResidue
BCYS195
BCYS200
BVAL217
BHOH2041

site_idAC4
Number of Residues3
DetailsBINDING SITE FOR RESIDUE ZN A 1358
ChainResidue
ACYS195
ACYS221
ACYS224

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:10078529, ECO:0000269|PubMed:10353245, ECO:0000269|PubMed:10367892, ECO:0000269|PubMed:11832950, ECO:0000269|PubMed:19389996, ECO:0000269|PubMed:24449914, ECO:0000269|PubMed:24915079, ECO:0000269|PubMed:26272610, ECO:0000269|PubMed:26349033, ECO:0000269|PubMed:28282025, ECO:0000269|PubMed:7885480, ECO:0007744|PDB:1IBR, ECO:0007744|PDB:1K5D, ECO:0007744|PDB:1QBK, ECO:0007744|PDB:1RRP, ECO:0007744|PDB:3GJX, ECO:0007744|PDB:3NBY, ECO:0007744|PDB:3NBZ, ECO:0007744|PDB:3NC0, ECO:0007744|PDB:3NC1, ECO:0007744|PDB:3ZJY, ECO:0007744|PDB:4C0Q, ECO:0007744|PDB:4OL0, ECO:0007744|PDB:5CLL, ECO:0007744|PDB:5CLQ, ECO:0007744|PDB:5DH9, ECO:0007744|PDB:5DHA, ECO:0007744|PDB:5DHF, ECO:0007744|PDB:5DI9, ECO:0007744|PDB:5DIF, ECO:0007744|PDB:5DIS, ECO:0007744|PDB:5DLQ, ECO:0007744|PDB:5JLJ, ECO:0007744|PDB:5UWH, ECO:0007744|PDB:5UWI, ECO:0007744|PDB:5UWJ, ECO:0007744|PDB:5UWO, ECO:0007744|PDB:5UWP, ECO:0007744|PDB:5UWQ, ECO:0007744|PDB:5UWR, ECO:0007744|PDB:5UWS, ECO:0007744|PDB:5UWT, ECO:0007744|PDB:5UWU, ECO:0007744|PDB:5UWW
ChainResidueDetails
CGLU1007
DGLU1007

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0000269|PubMed:31075303
ChainResidueDetails
CFAK1008
BTHR262
BASN286
BCYS324
DFAK1008
AGLN167
ATHR262
AASN286
ACYS324
BALA85
BASP95
BGLN167

site_idSWS_FT_FI3
Number of Residues8
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00236, ECO:0000269|PubMed:11427894, ECO:0000269|PubMed:23454361, ECO:0000269|PubMed:24389023, ECO:0000269|PubMed:25672491, ECO:0000269|PubMed:25704306, ECO:0007744|PDB:4R8M
ChainResidueDetails
ACYS195
ACYS200
ACYS221
ACYS224
BCYS195
BCYS200
BCYS221
BCYS224

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: N-acetylalanine => ECO:0007744|PubMed:19413330
ChainResidueDetails
AALA2
BALA2

site_idSWS_FT_FI5
Number of Residues6
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER23
ASER25
ASER27
BSER23
BSER25
BSER27

site_idSWS_FT_FI6
Number of Residues6
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q5RJQ4
ChainResidueDetails
ASER53
ASER100
ASER207
BSER53
BSER100
BSER207

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PDB entries from 2024-07-24

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