5JLJ
Crystal Structure of KPT8602 in complex with CRM1-Ran-RanBP1
Summary for 5JLJ
Entry DOI | 10.2210/pdb5jlj/pdb |
Descriptor | GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1, ... (9 entities in total) |
Functional Keywords | heat repeat, exportin-1, nuclear transport, transport receptor-inhibitor complex, protein transport |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 162225.08 |
Authors | Fung, H.Y.,Chook, Y.M. (deposition date: 2016-04-27, release date: 2016-06-29, Last modification date: 2023-09-27) |
Primary citation | Hing, Z.A.,Fung, H.Y.,Ranganathan, P.,Mitchell, S.,El-Gamal, D.,Woyach, J.A.,Williams, K.,Goettl, V.M.,Smith, J.,Yu, X.,Meng, X.,Sun, Q.,Cagatay, T.,Lehman, A.M.,Lucas, D.M.,Baloglu, E.,Shacham, S.,Kauffman, M.G.,Byrd, J.C.,Chook, Y.M.,Garzon, R.,Lapalombella, R. Next-generation XPO1 inhibitor shows improved efficacy and in vivo tolerability in hematological malignancies. Leukemia, 30:2364-2372, 2016 Cited by PubMed: 27323910DOI: 10.1038/leu.2016.136 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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