4R8M
Human SIRT2 crystal structure in complex with BHJH-TM1
Summary for 4R8M
Entry DOI | 10.2210/pdb4r8m/pdb |
Related | 3PKJ 3ZGO 3ZGV 4L3O |
Descriptor | NAD-dependent protein deacetylase sirtuin-2, BHJH-TM1 peptide, ZINC ION, ... (5 entities in total) |
Functional Keywords | rossmann fold, nad-dependent protein deacetylase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus. Isoform 1: Cytoplasm . Isoform 2: Cytoplasm . Isoform 5: Cytoplasm : Q8IXJ6 |
Total number of polymer chains | 4 |
Total formula weight | 73942.36 |
Authors | Teng, Y.B.,Hao, Q.,Lin, H.N.,Jing, H. (deposition date: 2014-09-02, release date: 2015-03-11, Last modification date: 2023-11-08) |
Primary citation | Teng, Y.B.,Jing, H.,Aramsangtienchai, P.,He, B.,Khan, S.,Hu, J.,Lin, H.,Hao, Q. Efficient Demyristoylase Activity of SIRT2 Revealed by Kinetic and Structural Studies Sci Rep, 5:8529-8529, 2015 Cited by PubMed: 25704306DOI: 10.1038/srep08529 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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