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신종 코로나바이러스 특집 콘텐츠

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코로나 바이러스
코로나 바이러스, 2020. David S. Goodsell @ RCSB PDB에 의한 오리지널 일러스트를 수정

신종 코로나바이러스 감염증 (Novel Coronavirus disease 2019:COVID-19)의 확산이 세계적으로 매우 큰 문제가 되고 있습니다. 시급히 새로운 바이러스(Severe Acute Respiratory Syndrome Coronavirus 2: SARS-CoV-2)를 이해하고 효과적인 약을 개발하기 위해, 신속하게 구조 생물학 연구가 시작되고 있습니다. PDBj는 사용자의 편의를 도모하기 위해 신종 코로나바이러스의 특집 페이지를 제공하고 있습니다. 매주 수요일에 최신 항목이 추가됩니다.

바이러스 단백질에 관한 해설기사는 아래의 「이달의 분자」 페이지를 참조하십시오.

「전체 엔트리」 탭에는, 모든 PDB ID가 포함되어 있습니다. 이용자가 전체의 독립된 엔트리를 검색하고 싶을 때 사용하실 수 있으며, 동일 저자에 의한 그룹등록의 엔트리도 전부 구별되어 있습니다. 「대표구조」 탭에는, 분해능이 가장 높은 대표구조만을 표지하고 있습니다. 아미노산 서열이 100 % 일치하는 PDB 엔트리의 경우, 다른 리간드를 포함하여도 대표구조에는 제외됩니다. 「최신 엔트리」 탭은, 이번주 공개된 가장 최근의 엔트리 입니다.


Created: 2020-09-03 (last edited: more than 1 year ago)2022-09-02
7T7B
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BU of 7t7b by Molmil
Crystal structure of SARS-CoV-2 spike protein receptor-binding domain in complex with a cross-neutralizing antibody ADI-62113 Fab
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ADI-62113 Fab heavy chain, ADI-62113 Fab light chain, ...
Authors:Liu, H, Wilson, I.A.
Deposit date:2021-12-14
Release date:2022-08-03
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Human antibodies to SARS-CoV-2 with a recurring YYDRxG motif retain binding and neutralization to variants of concern including Omicron.
Commun Biol, 5, 2022
7TCQ
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BU of 7tcq by Molmil
Crystal structure of SARS-CoV-2 neutralizing antibody WS6 in complex with spike S2 peptide
Descriptor: Anti-SARS-CoV-2 antibody WS6 Fab heavy chain, Anti-SARS-CoV-2 antibody WS6 Fab light chain, DI(HYDROXYETHYL)ETHER, ...
Authors:Zhou, T, Kwong, P.D.
Deposit date:2021-12-28
Release date:2022-08-03
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Vaccine-elicited murine antibody WS6 neutralizes diverse beta-coronaviruses by recognizing a helical stem supersite of vulnerability.
Structure, 30, 2022
7U09
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BU of 7u09 by Molmil
Crystal Structure of C13B8 Fab in complex with SARS-CoV-2 S fusion peptide
Descriptor: Heavy chain Fab C13B8, Light chain Fab C13B8, SARS-CoV-2 S fusion peptide
Authors:Tortorici, M.A, Veesler, D.
Deposit date:2022-02-17
Release date:2022-08-03
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:ACE2-binding exposes the SARS-CoV-2 fusion peptide to broadly neutralizing coronavirus antibodies.
Science, 377, 2022
7U0A
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BU of 7u0a by Molmil
Crystal Structure of C77G12 Fab in complex with SARS-CoV-2 S fusion peptide
Descriptor: CHLORIDE ION, Heavy chain Fab C77G12, Light chain Fab C77G12, ...
Authors:Tortorici, M.A, Veesler, D.
Deposit date:2022-02-17
Release date:2022-08-03
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:ACE2-binding exposes the SARS-CoV-2 fusion peptide to broadly neutralizing coronavirus antibodies.
Science, 377, 2022
7U0E
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BU of 7u0e by Molmil
Crystal Structure of C13C9 Fab in complex with SARS-CoV-2 S fusion peptide
Descriptor: Heavy chain Fab C13C9, Light chain Fab C13C9, SARS-CoV-2 S fusion peptide
Authors:Tortorici, M.A, Veesler, D.
Deposit date:2022-02-18
Release date:2022-08-03
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:ACE2-binding exposes the SARS-CoV-2 fusion peptide to broadly neutralizing coronavirus antibodies.
Science, 377, 2022
7VGR
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BU of 7vgr by Molmil
SARS-CoV-2 M protein dimer (long form) in complex with YN7756_1 Fab
Descriptor: Membrane protein, YN7756_1 Fab heavy chain, YN7756_1 Fab light chain
Authors:Zhang, Z, Ohto, U, Shimizu, T.
Deposit date:2021-09-18
Release date:2022-08-03
Last modified:2025-06-25
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Structure of SARS-CoV-2 membrane protein essential for virus assembly.
Nat Commun, 13, 2022
7VGS
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BU of 7vgs by Molmil
SARS-CoV-2 M protein dimer (short form) in complex with YN7717_9 Fab
Descriptor: Membrane protein, YN7717_9 Fab heavy chain, YN7717_9 Fab light chain
Authors:Zhang, Z, Ohto, U, Shimizu, T.
Deposit date:2021-09-18
Release date:2022-08-03
Last modified:2025-07-02
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structure of SARS-CoV-2 membrane protein essential for virus assembly.
Nat Commun, 13, 2022
8DF5
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BU of 8df5 by Molmil
SARS-CoV-2 Beta RBD in complex with human ACE2 and S304 Fab and S309 Fab
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:McCallum, M, Seattle Structural Genomics Center for Infectious Disease (SSGCID), Snell, G, Veesler, D.
Deposit date:2022-06-21
Release date:2022-08-03
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Shifting mutational constraints in the SARS-CoV-2 receptor-binding domain during viral evolution.
Science, 377, 2022
8DT3
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BU of 8dt3 by Molmil
Cryo-EM structure of spike binding to Fab of neutralizing antibody (locally refined)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain Fab of SW186, Light chain Fab of SW186, ...
Authors:Sun, P.C, Fang, Y, Bai, X.C, Chen, Z.J.
Deposit date:2022-07-25
Release date:2022-08-03
Last modified:2024-11-06
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:An antibody that neutralizes SARS-CoV-1 and SARS-CoV-2 by binding to a conserved spike epitope outside the receptor binding motif.
Sci Immunol, 7, 2022
7FJC
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BU of 7fjc by Molmil
Crystal structure of SARS-CoV-2 Beta RBD complexed with P36-5D2 Fab
Descriptor: P36-5D2 heavy chain, P36-5D2 light chain, Spike protein S1, ...
Authors:Zhang, L.Q, Wang, X.Q, Shan, S.S, Lan, J.
Deposit date:2021-08-03
Release date:2022-08-10
Last modified:2025-06-18
Method:X-RAY DIFFRACTION (2.96 Å)
Cite:A Potent and Protective Human Neutralizing Antibody Against SARS-CoV-2 Variants.
Front Immunol, 12, 2021
7STR
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BU of 7str by Molmil
Crystal Structure of Human Fab S24-1063 in the Complex with the N-teminal Domain of Nucleocapsid Protein from SARS CoV-2
Descriptor: 1,2-ETHANEDIOL, Fab S24-1063, Heavy chain, ...
Authors:Kim, Y, Maltseva, N, Tesar, C, Jedrzejczak, R, Dugan, H, Stamper, C, Wilson, P, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2021-11-15
Release date:2022-08-10
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Epitopes recognition of SARS-CoV-2 nucleocapsid RNA binding domain by human monoclonal antibodies.
Iscience, 27, 2024
7STS
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BU of 7sts by Molmil
Crystal Structure of Human Fab S24-1379 in the Complex with the N-teminal Domain of Nucleocapsid Protein from SARS CoV-2
Descriptor: Fab S24-1379, heavy chain, light chain, ...
Authors:Kim, Y, Maltseva, N, Tesar, C, Jedrzejczak, R, Dugan, H, Stamper, C, Wilson, P, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2021-11-15
Release date:2022-08-10
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Epitopes recognition of SARS-CoV-2 nucleocapsid RNA binding domain by human monoclonal antibodies.
Iscience, 27, 2024
7SUE
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BU of 7sue by Molmil
Crystal Structure of Human Fab S24-188 in the complex with the N-teminal Domain of Nucleocapsid protein from SARS CoV-2
Descriptor: Nucleoprotein, S24-188 Fab Heavy chain, S24-188 Fab Light chain
Authors:Kim, Y, Maltseva, N, Tesar, C, Jedrzejczak, R, Dugan, H, Stamper, C, Wilson, P, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2021-11-17
Release date:2022-08-10
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Epitopes recognition of SARS-CoV-2 nucleocapsid RNA binding domain by human monoclonal antibodies.
Iscience, 27, 2024
7U0P
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BU of 7u0p by Molmil
SARS-Cov2 S protein structure in complex with neutralizing monoclonal antibody 002-S21F2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
Authors:Patel, A, Ortlund, E.
Deposit date:2022-02-18
Release date:2022-08-10
Last modified:2024-10-30
Method:ELECTRON MICROSCOPY (3.76 Å)
Cite:Structural insights for neutralization of Omicron variants BA.1, BA.2, BA.4, and BA.5 by a broadly neutralizing SARS-CoV-2 antibody.
Sci Adv, 8, 2022
7UPL
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BU of 7upl by Molmil
SARS-Cov2 Omicron varient S protein structure in complex with neutralizing monoclonal antibody 002-S21F2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
Authors:Patel, A, Ortlund, E.
Deposit date:2022-04-15
Release date:2022-08-10
Last modified:2024-10-09
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Structural insights for neutralization of Omicron variants BA.1, BA.2, BA.4, and BA.5 by a broadly neutralizing SARS-CoV-2 antibody.
Sci Adv, 8, 2022
7V20
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BU of 7v20 by Molmil
CryoEM structure of del68-76/del679-688 prefusion-stabilized spike
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:Du, S, Xiao, J.
Deposit date:2021-08-07
Release date:2022-08-10
Last modified:2025-06-25
Method:ELECTRON MICROSCOPY (2.86 Å)
Cite:CryoEM structure of del68-76/del679-688 prefusion-stabilized spike
To Be Published
7V23
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BU of 7v23 by Molmil
CryoEM structure of del68-76/del679-688 prefusion-stabilized spike in complex with the Fab of N12-9
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
Authors:Du, S, Xiao, J.
Deposit date:2021-08-07
Release date:2022-08-10
Last modified:2025-07-02
Method:ELECTRON MICROSCOPY (2.96 Å)
Cite:CryoEM structure of del68-76/del679-688 prefusion-stabilized spike in complex with the Fab of N12-9
To Be Published
7V24
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BU of 7v24 by Molmil
Local CryoEM structure of del68-76/del679-688 prefusion-stabilized spike in complex with the Fab of N12-9
Descriptor: Spike glycoprotein, the heavy chain of N12-9 Fab, the lignt chain of N12-9 Fab
Authors:Du, S, Xiao, J.
Deposit date:2021-08-07
Release date:2022-08-10
Last modified:2025-06-25
Method:ELECTRON MICROSCOPY (3.29 Å)
Cite:Local CryoEM structure of del68-76/del679-688 prefusion-stabilized spike in complex with the Fab of N12-9
To Be Published
7V27
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BU of 7v27 by Molmil
RBD/XG005 local refinement
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, XG005-VH, ...
Authors:Zhan, W.Q, Zhang, X, Sun, L, Chen, Z.G.
Deposit date:2021-08-07
Release date:2022-08-10
Last modified:2025-07-02
Method:ELECTRON MICROSCOPY (4.18 Å)
Cite:RBD/XG005 local refinement
To Be Published
7VOA
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BU of 7voa by Molmil
Crystal structure of SARS-CoV-2 RBD in complex with aRBD5
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, alpaca nanobody
Authors:Ma, H, Zeng, W.H, Jin, T.C.
Deposit date:2021-10-13
Release date:2022-08-10
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Hetero-bivalent nanobodies provide broad-spectrum protection against SARS-CoV-2 variants of concern including Omicron.
Cell Res., 32, 2022
7WCD
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BU of 7wcd by Molmil
Cryo EM structure of SARS-CoV-2 spike in complex with TAU-2212 mAbs in conformation 4
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain, Light chain, ...
Authors:Xiang, Y, Ma, B, Li, R.
Deposit date:2021-12-19
Release date:2022-08-10
Last modified:2025-07-02
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Conformational flexibility in neutralization of SARS-CoV-2 by naturally elicited anti-SARS-CoV-2 antibodies.
Commun Biol, 5, 2022
7X6Y
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BU of 7x6y by Molmil
TRIM7 in complex with C-terminal peptide of NSP5
Descriptor: E3 ubiquitin-protein ligase TRIM7, peptide
Authors:Zhang, H, Liang, X, Li, X.Z.
Deposit date:2022-03-08
Release date:2022-08-10
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.39 Å)
Cite:A C-terminal glutamine recognition mechanism revealed by E3 ligase TRIM7 structures.
Nat.Chem.Biol., 18, 2022
7X6Z
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BU of 7x6z by Molmil
TRIM7 in complex with C-terminal peptide of NSP12
Descriptor: E3 ubiquitin-protein ligase TRIM7, peptide
Authors:Zhang, H, Liang, X, Li, X.Z.
Deposit date:2022-03-08
Release date:2022-08-10
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:A C-terminal glutamine recognition mechanism revealed by E3 ligase TRIM7 structures.
Nat.Chem.Biol., 18, 2022
7X70
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BU of 7x70 by Molmil
TRIM7 in complex with C-terminal peptide of NSP8
Descriptor: E3 ubiquitin-protein ligase TRIM7, peptide
Authors:Zhang, H, Liang, X, Li, X.Z.
Deposit date:2022-03-08
Release date:2022-08-10
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:A C-terminal glutamine recognition mechanism revealed by E3 ligase TRIM7 structures.
Nat.Chem.Biol., 18, 2022
7W8S
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BU of 7w8s by Molmil
Structure of SARS-CoV-2 spike receptor-binding domain Y453F mutation complexed with American mink ACE2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, Spike protein S1, ...
Authors:Su, C, Qi, J.X, Gao, G.F.
Deposit date:2021-12-08
Release date:2022-08-17
Last modified:2024-10-23
Method:ELECTRON MICROSCOPY (2.85 Å)
Cite:Molecular Basis of Mink ACE2 Binding to SARS-CoV-2 and Its Mink-Derived Variants.
J.Virol., 96, 2022

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