Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

신종 코로나바이러스 특집 콘텐츠

이 페이지는 다른 언어로도 제공됩니다: English日本語简体中文繁體中文
코로나 바이러스
코로나 바이러스, 2020. David S. Goodsell @ RCSB PDB에 의한 오리지널 일러스트를 수정

신종 코로나바이러스 감염증 (Novel Coronavirus disease 2019:COVID-19)의 확산이 세계적으로 매우 큰 문제가 되고 있습니다. 시급히 새로운 바이러스(Severe Acute Respiratory Syndrome Coronavirus 2: SARS-CoV-2)를 이해하고 효과적인 약을 개발하기 위해, 신속하게 구조 생물학 연구가 시작되고 있습니다. PDBj는 사용자의 편의를 도모하기 위해 신종 코로나바이러스의 특집 페이지를 제공하고 있습니다. 매주 수요일에 최신 항목이 추가됩니다.

바이러스 단백질에 관한 해설기사는 아래의 「이달의 분자」 페이지를 참조하십시오.

「전체 엔트리」 탭에는, 모든 PDB ID가 포함되어 있습니다. 이용자가 전체의 독립된 엔트리를 검색하고 싶을 때 사용하실 수 있으며, 동일 저자에 의한 그룹등록의 엔트리도 전부 구별되어 있습니다. 「대표구조」 탭에는, 분해능이 가장 높은 대표구조만을 표지하고 있습니다. 아미노산 서열이 100 % 일치하는 PDB 엔트리의 경우, 다른 리간드를 포함하여도 대표구조에는 제외됩니다. 「최신 엔트리」 탭은, 이번주 공개된 가장 최근의 엔트리 입니다.


Created: 2020-09-03 (last edited: more than 1 year ago)2022-09-02
8HVK
DownloadVisualize
BU of 8hvk by Molmil
Crystal structure of SARS-Cov-2 main protease G15S mutant in complex with PF07321332
Descriptor: (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase nsp5
Authors:Zeng, P, Zhang, J, Li, J.
Deposit date:2022-12-27
Release date:2023-12-27
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Crystal structure of SARS-Cov-2 main protease G15S mutant in complex with PF07321332
To Be Published
8HVL
DownloadVisualize
BU of 8hvl by Molmil
Crystal structure of SARS-Cov-2 main protease M49I mutant in complex with PF07321332
Descriptor: (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase nsp5
Authors:Zou, X.F, Zhang, J, Li, J.
Deposit date:2022-12-27
Release date:2023-12-27
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Crystal structure of SARS-Cov-2 main protease M49I mutant in complex with PF07321332
To Be Published
8HVM
DownloadVisualize
BU of 8hvm by Molmil
Crystal structure of SARS-Cov-2 main protease K90R mutant in complex with PF07321332
Descriptor: (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase nsp5
Authors:Wang, J, Zhang, J, Li, J.
Deposit date:2022-12-27
Release date:2023-12-27
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Crystal structure of SARS-Cov-2 main protease K90R mutant in complex with PF07321332
To Be Published
8HVN
DownloadVisualize
BU of 8hvn by Molmil
Crystal structure of SARS-Cov-2 main protease P132H mutant in complex with PF07321332
Descriptor: (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase nsp5
Authors:Li, W.W, Zhang, J, Li, J.
Deposit date:2022-12-27
Release date:2023-12-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of SARS-Cov-2 main protease P132H mutant in complex with PF07321332
To Be Published
8HVO
DownloadVisualize
BU of 8hvo by Molmil
Crystal structure of SARS-Cov-2 main protease V186F mutant in complex with PF07321332
Descriptor: (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase nsp5
Authors:Zou, X.F, Zhang, J, Li, J.
Deposit date:2022-12-27
Release date:2023-12-27
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystal structure of SARS-Cov-2 main protease V186F mutant in complex with PF07321332
To Be Published
8I4E
DownloadVisualize
BU of 8i4e by Molmil
Omicron spike variant XBB with Bn03
Descriptor: Bn03, Spike glycoprotein
Authors:Hao, A.H, Zhang, X, Chen, Z.G, Sun, L.
Deposit date:2023-01-19
Release date:2023-12-27
Method:ELECTRON MICROSCOPY (3.98 Å)
Cite:Defining a highly conserved cryptic epitope for antibody recognition of SARS-CoV-2 variants.
Signal Transduct Target Ther, 8, 2023
8I4F
DownloadVisualize
BU of 8i4f by Molmil
Omicron spike variant XBB with n3130v-Fc
Descriptor: Spike glycoprotein, n3130v-Fc
Authors:Hao, A.H, Zhang, X, Chen, Z.G, Sun, L.
Deposit date:2023-01-19
Release date:2023-12-27
Method:ELECTRON MICROSCOPY (3.44 Å)
Cite:Defining a highly conserved cryptic epitope for antibody recognition of SARS-CoV-2 variants.
Signal Transduct Target Ther, 8, 2023
8I4G
DownloadVisualize
BU of 8i4g by Molmil
Omicron spike variant BQ.1.1 with n3130v-Fc
Descriptor: Spike glycoprotein, n3130v-Fc
Authors:Hao, A.H, Zhang, X, Chen, Z.G, Sun, L.
Deposit date:2023-01-19
Release date:2023-12-27
Method:ELECTRON MICROSCOPY (3.68 Å)
Cite:Defining a highly conserved cryptic epitope for antibody recognition of SARS-CoV-2 variants.
Signal Transduct Target Ther, 8, 2023
8JJE
DownloadVisualize
BU of 8jje by Molmil
RBD of SARS-CoV2 spike protein with ACE2 decoy
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ...
Authors:Kishikawa, J, Hirose, M, Kato, T, Okamoto, T.
Deposit date:2023-05-30
Release date:2023-12-27
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:An inhaled ACE2 decoy confers protection against SARS-CoV-2 infection in preclinical models.
Sci Transl Med, 15, 2023
8K5G
DownloadVisualize
BU of 8k5g by Molmil
Structure of the SARS-CoV-2 BA.1 RBD with UT28-RD
Descriptor: Spike protein S1, UT28K-RD Fab Heavy chain, UT28K-RD Fab Light chain
Authors:Chen, L, Kita, S, Anraku, Y, Maenaka, K.
Deposit date:2023-07-21
Release date:2023-12-27
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (3.41 Å)
Cite:Rational in silico design identifies two mutations that restore UT28K SARS-CoV-2 monoclonal antibody activity against Omicron BA.1.
Structure, 32, 2024
8K5H
DownloadVisualize
BU of 8k5h by Molmil
Structure of the SARS-CoV-2 BA.1 spike with UT28-RD
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
Authors:Chen, L, Kita, S, Anraku, Y, Maenaka, K.
Deposit date:2023-07-21
Release date:2023-12-27
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (3.22 Å)
Cite:Rational in silico design identifies two mutations that restore UT28K SARS-CoV-2 monoclonal antibody activity against Omicron BA.1.
Structure, 32, 2024
8TH1
DownloadVisualize
BU of 8th1 by Molmil
Crystal Structure of the G3BP1 NTF2-like domain bound to the IDR1 of SARS-CoV-2 nucleocapsid protein D3L mutant
Descriptor: Nucleoprotein, Ras GTPase-activating protein-binding protein 1
Authors:Hughes, M.P, Taylor, J.P, Yang, Z.
Deposit date:2023-07-13
Release date:2023-12-27
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication and pathogenicity.
Cell Rep, 43, 2024
8IHO
DownloadVisualize
BU of 8iho by Molmil
Crystal structures of SARS-CoV-2 papain-like protease in complex with covalent inhibitors
Descriptor: Papain-like protease nsp3, ZINC ION, covalent inhibitor
Authors:Wang, Q, Hu, H, Li, M, Xu, Y.
Deposit date:2023-02-23
Release date:2024-01-03
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structure-Based Design of Potent Peptidomimetic Inhibitors Covalently Targeting SARS-CoV-2 Papain-like Protease.
Int J Mol Sci, 24, 2023
8JYK
DownloadVisualize
BU of 8jyk by Molmil
Structure of the SARS-CoV-2 XBB.1.5 spike glycoprotein (closed state 1)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:Yajima, H, Anraku, Y, Kita, S, Kimura, K, Sasaki, J, Sasaki-Tabata, K, Maenaka, K, Hashiguchi, T.
Deposit date:2023-07-03
Release date:2024-01-03
Method:ELECTRON MICROSCOPY (2.59 Å)
Cite:Virological characteristics of the SARS-CoV-2 XBB.1.5 variant
To Be Published
8JYM
DownloadVisualize
BU of 8jym by Molmil
Structure of the SARS-CoV-2 XBB.1.5 spike glycoprotein (closed state 2)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:Yajima, H, Anraku, Y, Kita, S, Kimura, K, Sasaki, J, Sasaki-Tabata, K, Maenaka, K, Hashiguchi, T.
Deposit date:2023-07-03
Release date:2024-01-03
Method:ELECTRON MICROSCOPY (2.79 Å)
Cite:Virological characteristics of the SARS-CoV-2 XBB.1.5 variant
To Be Published
8JYN
DownloadVisualize
BU of 8jyn by Molmil
Structure of SARS-CoV-2 XBB.1.5 spike glycoprotein in complex with ACE2 (1-up state)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, ...
Authors:Yajima, H, Anraku, Y, Kita, S, Kimura, K, Sasaki, J, Sasaki-Tabata, K, Maenaka, K, Hashiguchi, T.
Deposit date:2023-07-03
Release date:2024-01-03
Method:ELECTRON MICROSCOPY (3.04 Å)
Cite:Virological characteristics of the SARS-CoV-2 XBB.1.5 variant
To Be Published
8JYO
DownloadVisualize
BU of 8jyo by Molmil
Structure of SARS-CoV-2 XBB.1.5 spike glycoprotein in complex with ACE2 (2-up state)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, ...
Authors:Yajima, H, Anraku, Y, Kita, S, Kimura, K, Sasaki, J, Sasaki-Tabata, K, Maenaka, K, Hashiguchi, T.
Deposit date:2023-07-03
Release date:2024-01-03
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Virological characteristics of the SARS-CoV-2 XBB.1.5 variant
To Be Published
8JYP
DownloadVisualize
BU of 8jyp by Molmil
Structure of SARS-CoV-2 XBB.1.5 spike RBD in complex with ACE2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, ...
Authors:Yajima, H, Anraku, Y, Kita, S, Kimura, K, Sasaki, J, Sasaki-Tabata, K, Maenaka, K, Hashiguchi, T.
Deposit date:2023-07-03
Release date:2024-01-03
Method:ELECTRON MICROSCOPY (3.38 Å)
Cite:Virological characteristics of the SARS-CoV-2 XBB.1.5 variant
To Be Published
8FHY
DownloadVisualize
BU of 8fhy by Molmil
Crystal structure of the SARS-CoV-2 receptor binding domain in complex with neutralizing antibody WRAIR-5021
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, MALONATE ION, ...
Authors:Sankhala, R.S, Jensen, J.L, Joyce, M.G.
Deposit date:2022-12-15
Release date:2024-01-17
Method:X-RAY DIFFRACTION (2.53 Å)
Cite:Diverse array of neutralizing antibodies elicited upon Spike Ferritin Nanoparticle vaccination in rhesus macaques.
Nat Commun, 15, 2024
8FI9
DownloadVisualize
BU of 8fi9 by Molmil
Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody WRAIR-5001
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Spike protein S1, ...
Authors:Sankhala, R.S, Jensen, J.L, Joyce, M.G.
Deposit date:2022-12-15
Release date:2024-01-17
Method:X-RAY DIFFRACTION (4.2 Å)
Cite:Diverse array of neutralizing antibodies elicited upon Spike Ferritin Nanoparticle vaccination in rhesus macaques.
Nat Commun, 15, 2024
8FTL
DownloadVisualize
BU of 8ftl by Molmil
Crystal structure of the SARS-CoV-2 (COVID-19) main protease (Mpro) in complex with inhibitor Jun89-3-C1
Descriptor: 3C-like proteinase nsp5, N-([1,1'-biphenyl]-4-yl)-2-chloro-N-[(1R)-2-oxo-2-{[(1S)-1-phenylethyl]amino}-1-(pyridin-3-yl)ethyl]acetamide
Authors:Lewandowski, E.M, Butler, S.G, Hu, Y, Tan, H, Wang, J, Chen, Y.
Deposit date:2023-01-12
Release date:2024-01-17
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Crystal structure of the SARS-CoV-2 (COVID-19) main protease (Mpro) in complex with inhibitor Jun89-3-C1
To Be Published
8HVU
DownloadVisualize
BU of 8hvu by Molmil
Crystal structure of SARS-Cov-2 main protease G15S mutant in complex with PF07304814
Descriptor: 3C-like proteinase nsp5, [(3~{S})-3-[[(2~{S})-2-[(4-methoxy-1~{H}-indol-2-yl)carbonylamino]-4-methyl-pentanoyl]amino]-2-oxidanylidene-4-[(3~{R})-2-oxidanylidene-3,4-dihydropyrrol-3-yl]butyl] dihydrogen phosphate
Authors:Zeng, P, Zhang, J, Li, J.
Deposit date:2022-12-28
Release date:2024-01-17
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Crystal structures of main protease (M pro ) mutants of SARS-CoV-2 variants bound to PF-07304814.
Mol Biomed, 4, 2023
8HVV
DownloadVisualize
BU of 8hvv by Molmil
Crystal structure of SARS-Cov-2 main protease S46F mutant in complex with PF07304814
Descriptor: 3C-like proteinase nsp5, [(3~{S})-3-[[(2~{S})-2-[(4-methoxy-1~{H}-indol-2-yl)carbonylamino]-4-methyl-pentanoyl]amino]-2-oxidanylidene-4-[(3~{R})-2-oxidanylidene-3,4-dihydropyrrol-3-yl]butyl] dihydrogen phosphate
Authors:Zeng, X.Y, Zhang, J, Li, J.
Deposit date:2022-12-28
Release date:2024-01-17
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structures of main protease (M pro ) mutants of SARS-CoV-2 variants bound to PF-07304814.
Mol Biomed, 4, 2023
8HVW
DownloadVisualize
BU of 8hvw by Molmil
Crystal structure of SARS-Cov-2 main protease M49I mutant in complex with PF07304814
Descriptor: 3C-like proteinase nsp5, [(3~{S})-3-[[(2~{S})-2-[(4-methoxy-1~{H}-indol-2-yl)carbonylamino]-4-methyl-pentanoyl]amino]-2-oxidanylidene-4-[(3~{R})-2-oxidanylidene-3,4-dihydropyrrol-3-yl]butyl] dihydrogen phosphate
Authors:Zou, X.F, Zhang, J, Li, J.
Deposit date:2022-12-28
Release date:2024-01-17
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal structures of main protease (M pro ) mutants of SARS-CoV-2 variants bound to PF-07304814.
Mol Biomed, 4, 2023
8HVX
DownloadVisualize
BU of 8hvx by Molmil
Crystal structure of SARS-Cov-2 main protease Y54C mutant in complex with PF07304814
Descriptor: 3C-like proteinase nsp5, [(3~{S})-3-[[(2~{S})-2-[(4-methoxy-1~{H}-indol-2-yl)carbonylamino]-4-methyl-pentanoyl]amino]-2-oxidanylidene-4-[(3~{R})-2-oxidanylidene-3,4-dihydropyrrol-3-yl]butyl] dihydrogen phosphate
Authors:Zhou, X.L, Zhang, J, Li, J.
Deposit date:2022-12-28
Release date:2024-01-17
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal structures of main protease (M pro ) mutants of SARS-CoV-2 variants bound to PF-07304814.
Mol Biomed, 4, 2023

222415

건을2024-07-10부터공개중

PDB statisticsPDBj update infoContact PDBjnumon