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新型コロナウイルスの構造情報

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コロナウイルス
コロナウイルス, 2020. David S. Goodsell@RCSB PDB による原画を修正

最近、新型コロナウイルス感染症(Novel Coronavirus disease 2019: COVID-19)の拡大が世界中で深刻な問題となっています。早急にこの新型ウイルス(Severe Acute Respiratory Syndrome Coronavirus 2: SARS-CoV-2)を理解し有効な薬を開発するため,関連するタンパク質の構造研究は既に始まっています。そして,解明された構造はPDBに登録されていっています。PDBjでは利用者の利便を図るため,新型コロナウイルス特集ページを作成しました。新たなエントリーが毎週水曜日の週次更新で公開されると、同時にこのページにも追加されます。

またこのウイルスのタンパク質に関する解説記事を以下の「今月の分子」ページに掲載しています。

「全エントリー」のタブでは,同じ著者によるグループ登録のエントリーも全て区別し,すべてのPDB IDを省略せず表示しています。 「代表構造」タブには最も分解能の高い代表構造のみを表示しており,アミノ酸配列が100%同じPDBエントリーはリガンドが異なるものも含め除外してあります。 「最新のエントリー」のタブは,今週公開された最も新しいエントリーです。


作成日: 2020-09-03 (最終更新日: more than 1 year ago)2022-09-02
8SIR
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BU of 8sir by Molmil
Crystal structure of SARS-CoV-2 spike receptor-binding domain in complex with broadly neutralizing antibody CC25.54 Fab
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CC25.54 Fab heavy chain, CC25.54 Fab light chain, ...
著者Liu, H, Wilson, I.A.
登録日2023-04-16
公開日2024-03-13
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Broadly neutralizing antibodies targeting a conserved silent face of spike RBD resist extreme SARS-CoV-2 antigenic drift
Biorxiv, 2023
8SIS
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BU of 8sis by Molmil
Crystal structure of SARS-CoV-2 spike receptor-binding domain in complex with broadly neutralizing antibody CC84.2 Fab
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CC84.2 Fab heavy chain, CC84.2 Fab light chain, ...
著者Liu, H, Wilson, I.A.
登録日2023-04-16
公開日2024-03-13
実験手法X-RAY DIFFRACTION (3.08 Å)
主引用文献Broadly neutralizing antibodies targeting a conserved silent face of spike RBD resist extreme SARS-CoV-2 antigenic drift
Biorxiv, 2023
8SIT
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BU of 8sit by Molmil
Crystal structure of SARS-CoV-2 spike receptor-binding domain in complex with broadly neutralizing antibody CC84.24 Fab
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CC84.24 fab heavy chain, CC84.24 fab light chain, ...
著者Liu, H, Wilson, I.A.
登録日2023-04-16
公開日2024-03-13
実験手法X-RAY DIFFRACTION (2.91 Å)
主引用文献Broadly neutralizing antibodies targeting a conserved silent face of spike RBD resist extreme SARS-CoV-2 antigenic drift
Biorxiv, 2023
8UHO
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BU of 8uho by Molmil
Crystal structure of SARS CoV-2 3CL protease in complex with GSK4365096A
分子名称: 3C-like proteinase nsp5, N-[(benzyloxy)carbonyl]-4-fluoro-L-phenylalanyl-N-[(2S,3Z)-1-[(2S)-oxolan-2-yl]-3-(2-oxooxolan-3-ylidene)propan-2-yl]-L-leucinamide
著者Concha, N.O, Williams, S.P.
登録日2023-10-09
公開日2024-03-13
実験手法X-RAY DIFFRACTION (2.02 Å)
主引用文献Exploration of the P1 residue in 3CL protease inhibitors leading to the discovery of a 2-tetrahydrofuran P1 replacement.
Bioorg.Med.Chem., 100, 2024
8AZI
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BU of 8azi by Molmil
Structure of SARS-CoV-2 NSP3 macrodomain in complex with 2'-deoxy-ADPR
分子名称: 2'-deoxyadenosine 5'-diphosphoribose, Papain-like protease nsp3
著者Sander, S, Tidow, H, Fliegert, R, Sandmann, M.
登録日2022-09-06
公開日2024-03-20
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structure of SARS-CoV-2 NSP3 macrodomain in the apo form
To Be Published
8AZL
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BU of 8azl by Molmil
Structure of SARS-CoV-2 NSP3 macrodomain in complex with 2'-deoxy-2'-fluoro-ADPR
分子名称: 2'-deoxyadenosine 5'-fluoro-diphosphoribose, Papain-like protease nsp3
著者Sander, S, Tidow, H, Fliegert, R, Sandmann, M.
登録日2022-09-06
公開日2024-03-20
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structure of SARS-CoV-2 NSP3 macrodomain in complex with 2'-deoxy-2'-fluoro-ADPR
To Be Published
8AZM
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BU of 8azm by Molmil
Structure of SARS-CoV-2 NSP3 macrodomain in complex with 8Br-ADPR
分子名称: 8-bromoadenosine 5'-diphosphoribose, Papain-like protease nsp3
著者Sander, S, Tidow, H, Fliegert, R, Sandmann, M.
登録日2022-09-06
公開日2024-03-20
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structure of SARS-CoV-2 NSP3 macrodomain in complex with 8Br-ADPR
To Be Published
8AZN
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BU of 8azn by Molmil
Structure of SARS-CoV-2 NSP3 macrodomain in complex with alpha-1-O-Me-ADPR
分子名称: Adenosine 5'-diphosphoric acid beta-[(3beta,4beta-dihydroxy-5beta-methoxytetrahydrofuran-2alpha-yl)methyl] estere, Papain-like protease nsp3
著者Sander, S, Tidow, H, Fliegert, R, Sandmann, M.
登録日2022-09-06
公開日2024-03-20
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structure of SARS-CoV-2 NSP3 macrodomain in complex with alpha-1-O-Me-ADPR
To Be Published
8AZO
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BU of 8azo by Molmil
Structure of SARS-CoV-2 NSP3 macrodomain in complex with beta-ethyl-ADP
分子名称: Papain-like protease nsp3, beta-ethyl-adenosine diphosphate
著者Sander, S, Tidow, H, Fliegert, R, Sandmann, M.
登録日2022-09-06
公開日2024-03-20
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structure of SARS-CoV-2 NSP3 macrodomain in complex with beta-ethyl-ADP
To Be Published
8AZP
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BU of 8azp by Molmil
Structure of SARS-CoV-2 NSP3 macrodomain in complex with beta-methyl-ADP
分子名称: Papain-like protease nsp3, beta-methyl-adenosine diphosphate
著者Sander, S, Tidow, H, Fliegert, R, Sandmann, M.
登録日2022-09-06
公開日2024-03-20
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structure of SARS-CoV-2 NSP3 macrodomain in complex with beta-methyl-ADP
To Be Published
8S8W
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BU of 8s8w by Molmil
SARS-CoV-2 nsp10-16 methyltransferase in complex with Sangivamycin and m7GpppA-RNA (Cap0-RNA)
分子名称: 1,2-ETHANEDIOL, 2'-O-methyltransferase nsp16, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ...
著者Kremling, V, Sprenger, J, Oberthuer, D, Scheer, T.E.S.
登録日2024-03-07
公開日2024-03-20
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献SARS-CoV-2 methyltransferase nsp10-16 in complex with natural and drug-like purine analogs for guiding structure-based drug development
To Be Published
8S8X
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BU of 8s8x by Molmil
SARS-CoV-2 nsp10-16 methyltransferase in complex with Toyocamycin and m7GpppA-RNA (Cap0-RNA)
分子名称: 2'-O-methyltransferase nsp16, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-amino-7-(beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile, ...
著者Kremling, V, Sprenger, J, Oberthuer, D, Scheer, T.E.S.
登録日2024-03-07
公開日2024-03-20
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献SARS-CoV-2 methyltransferase nsp10-16 in complex with natural and drug-like purine analogs for guiding structure-based drug development
To Be Published
8TH5
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BU of 8th5 by Molmil
Crystal Structure of the G3BP1 NTF2-like domain bound to the IDR1 of SARS-CoV-2 nucleocapsid protein P13L mutant
分子名称: Nucleoprotein, Ras GTPase-activating protein-binding protein 1
著者Hughes, M.P, Taylor, J.P, Yang, Z.
登録日2023-07-13
公開日2024-03-20
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.62 Å)
主引用文献Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication and pathogenicity.
Cell Rep, 43, 2024
8VEC
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BU of 8vec by Molmil
Deep Mutational Scanning of SARS-CoV-2 PLpro
分子名称: Papain-like protease nsp3, ZINC ION
著者Wu, X, Nguyen, J.V, Call, M.E, Call, M.J.
登録日2023-12-18
公開日2024-03-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Mutational Profiling of SARS-CoV-2 PLpro in human cells reveals requirements for function, structure, and drug escape
Biorxiv, 2024
9EMJ
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BU of 9emj by Molmil
SARS-CoV-2 methyltransferase nsp10-16 in complex with Toyocamycin and m7GpppA (Cap0-analog)
分子名称: 1,2-ETHANEDIOL, 2'-O-methyltransferase nsp16, 4-amino-7-(beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile, ...
著者Kremling, V, Sprenger, J, Oberthuer, D, Kiene, A.
登録日2024-03-08
公開日2024-03-20
実験手法X-RAY DIFFRACTION (1.79 Å)
主引用文献SARS-CoV-2 methyltransferase nsp10-16 in complex with natural and drug-like purine analogs for guiding structure-based drug development
To Be Published
9EML
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BU of 9eml by Molmil
SARS-CoV-2 methyltransferase nsp10-16 in complex with SAM and m7GpppA (Cap0-analog)/m7GpppAm (Cap1-analog)
分子名称: 1,2-ETHANEDIOL, 2'-O-methyltransferase nsp16, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ...
著者Kremling, V, Sprenger, J, Oberthuer, D, Kiene, A.
登録日2024-03-08
公開日2024-03-20
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献SARS-CoV-2 methyltransferase nsp10-16 in complex with natural and drug-like purine analogs for guiding structure-based drug development
To Be Published
9EMV
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BU of 9emv by Molmil
SARS-CoV-2 nsp10-16 methyltransferase in complex with Sangivamycin and m7GpppA (Cap0-analog)/m7GpppAm (Cap1-analog)
分子名称: 1,2-ETHANEDIOL, 2'-O-methyltransferase nsp16, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ...
著者Kremling, V, Sprenger, J, Oberthuer, D, Scheer, T.E.S.
登録日2024-03-11
公開日2024-03-20
実験手法X-RAY DIFFRACTION (2.34 Å)
主引用文献SARS-CoV-2 methyltransferase nsp10-16 in complex with natural and drug-like purine analogs for guiding structure-based drug development
To Be Published
8VYE
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BU of 8vye by Molmil
SARS-CoV-2 S (C.37 Lambda variant) plus S309, S2L20, and S2X303 Fabs
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, S2L20 Heavy Chain, S2L20 Light Chain, ...
著者McCallum, M, Veesler, D, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2024-02-08
公開日2024-03-27
実験手法ELECTRON MICROSCOPY (2.7 Å)
主引用文献Quantifying how single dose Ad26.COV2.S vaccine efficacy depends on Spike sequence features.
Nat Commun, 15, 2024
8VYF
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BU of 8vyf by Molmil
SARS-CoV-2 S NTD (C.37 Lambda variant) plus S2L20 and S2X303 Fabs, local refinement
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, S2L20 Heavy Chain, ...
著者McCallum, M, Veesler, D, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2024-02-08
公開日2024-03-27
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Quantifying how single dose Ad26.COV2.S vaccine efficacy depends on Spike sequence features.
Nat Commun, 15, 2024
8VYG
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BU of 8vyg by Molmil
SARS-CoV-2 S RBD (C.37 Lambda variant) plus S309 Fab, local refinement
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, S309 Heavy Chain, S309 Light Chain, ...
著者McCallum, M, Veesler, D, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2024-02-08
公開日2024-03-27
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Quantifying how single dose Ad26.COV2.S vaccine efficacy depends on Spike sequence features.
Nat Commun, 15, 2024
8WLO
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BU of 8wlo by Molmil
Cryo-EM structure of SARS-CoV-2 prototype spike protein in complex with hippopotamus ACE2
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme, ...
著者Han, P, Yang, R.R, Li, S.H.
登録日2023-09-30
公開日2024-03-27
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (2.62 Å)
主引用文献Molecular basis of hippopotamus ACE2 binding to SARS-CoV-2.
J.Virol., 98, 2024
8WLR
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BU of 8wlr by Molmil
Cryo-EM structure of SARS-CoV-2 prototype spike protein receptor-binding domain in complex with hippopotamus ACE2
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme, Spike glycoprotein, ...
著者Han, P, Yang, R.R, Li, S.H.
登録日2023-09-30
公開日2024-03-27
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (3.12 Å)
主引用文献Molecular basis of hippopotamus ACE2 binding to SARS-CoV-2.
J.Virol., 98, 2024
8QZR
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BU of 8qzr by Molmil
SARS-CoV-2 delta RBD complexed with BA.4/5-9 Fab
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, BA.4/5-9 heavy chain, BA.4/5-9 light chain, ...
著者Zhou, D, Ren, J, Stuart, D.I.
登録日2023-10-29
公開日2024-04-03
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (3.77 Å)
主引用文献Emerging variants develop total escape from potent monoclonal antibodies induced by BA.4/5 infection.
Nat Commun, 15, 2024
8S9Z
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BU of 8s9z by Molmil
Mpro inhibitors of SARS-CoV-2
分子名称: 3C-like proteinase nsp5, Mpro inhibitor
著者Blankenship, L.R, Liu, W.R.
登録日2023-03-30
公開日2024-04-03
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structure of MPI89 with Mpro of SARS-CoV-2 at 1.85A resolution.
To Be Published
8UOB
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BU of 8uob by Molmil
SARS-CoV-2 Papain-like protease (PLpro) with Inhibitor Jun12682
分子名称: 5-[2-(dimethylamino)ethoxy]-N-{(1R)-1-[(3M,5P)-3-(1-ethyl-1H-pyrazol-3-yl)-5-(1-methyl-1H-pyrazol-4-yl)phenyl]ethyl}-2-methylbenzamide, CHLORIDE ION, Papain-like protease nsp3, ...
著者Ansari, A, Tan, B, Ruiz, F.X, Wang, J, Arnold, E.
登録日2023-10-19
公開日2024-04-03
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.52 Å)
主引用文献Design of a SARS-CoV-2 papain-like protease inhibitor with antiviral efficacy in a mouse model.
Science, 383, 2024

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件を2024-07-10に公開中

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