8VEC

Deep Mutational Scanning of SARS-CoV-2 PLpro

Summary for 8VEC

• Entry DOI: 10.2210/pdb8vec/pdb
• Descriptor: Papain-like protease nsp3, ZINC ION (3 entities in total)
• Functional Keywords: papain-like protease, sars-cov-2, mutation, hydrolase
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2)
• Total number of polymer chains: 1
• Total formula weight: 36103.28

Authors

Wu, X.,Nguyen, J.V.,Call, M.E.,Call, M.J. (deposition date: 2023-12-18, release date: 2024-03-20)

• Primary citation: Wu, X.,Go, M.,Nguyen, J.V.,Kuchel, N.W.,Lu, B.G.C.,Lowes, K.N.,Calleja, D.J.,Mitchell, J.P.,Lessene, G.,Komander, D.,Call, M.E.,Call, M.J.; Mutational Profiling of SARS-CoV-2 PLpro in human cells reveals requirements for function, structure, and drug escape; Biorxiv, 2024; DOI: 10.1101/2024.03.11.584210

Experimental method

X-RAY DIFFRACTION (2 Å)