8S8X

SARS-CoV-2 nsp10-16 methyltransferase in complex with Toyocamycin and m7GpppA-RNA (Cap0-RNA)

Summary for 8S8X

• Entry DOI: 10.2210/pdb8s8x/pdb
• Related: 8BSD 8BZV 8C5M 8OSX 8OT0 8OTR 8OV1
• Descriptor: 2'-O-methyltransferase nsp16, Non-structural protein 10, m7GpppA-RNA (Cap0-RNA), ... (9 entities in total)
• Functional Keywords: methyltransferase, complex, inhibitor, viral protein
• Biological source: Severe acute respiratory syndrome coronavirus 2; More
• Total number of polymer chains: 3
• Total formula weight: 51335.72

Authors

Kremling, V.,Sprenger, J.,Oberthuer, D.,Scheer, T.E.S. (deposition date: 2024-03-07, release date: 2024-03-20, Last modification date: 2024-11-13)

• Primary citation: Kremling, V.,Falke, S.,Fernandez-Garcia, Y.,Ehrt, C.,Kiene, A.,Klopprogge, B.,Scheer, E.,Barthels, F.,Middendorf, P.,Kuhn, S.,Gunther, S.,Rarey, M.,Chapman, H.N.,Oberthur, D.,Sprenger, J.; SARS-CoV-2 methyltransferase nsp10-16 in complex with natural and drug-like purine analogs for guiding structure-based drug discovery; Elife, 2024; DOI: 10.7554/elife.98310.1

Experimental method

X-RAY DIFFRACTION (1.99 Å)