8UUH

SARS-CoV-2 papain-like protease (PLpro) with inhibitor Jun12199

Summary for 8UUH

• Entry DOI: 10.2210/pdb8uuh/pdb
• Descriptor: Papain-like protease nsp3, 5-[2-(dimethylamino)ethoxy]-2-methyl-N-[(1R)-1-{(3M,5P)-3-(1-methyl-1H-pyrazol-4-yl)-5-[1-(propan-2-yl)-1H-pyrazol-4-yl]phenyl}ethyl]benzamide, DI(HYDROXYETHYL)ETHER, ... (6 entities in total)
• Functional Keywords: sars cov-2 papain like protease complex with jun12199, viral protein, hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, 2019-nCoV, COVID-19 virus)
• Total number of polymer chains: 1
• Total formula weight: 37139.52

Authors

Ansari, A.,Tan, B.,Ruiz, F.X.,Arnold, E.,Wang, J. (deposition date: 2023-11-01, release date: 2024-04-03)

• Primary citation: Tan, B.,Zhang, X.,Ansari, A.,Jadhav, P.,Tan, H.,Li, K.,Chopra, A.,Ford, A.,Chi, X.,Ruiz, F.X.,Arnold, E.,Deng, X.,Wang, J.; Design of a SARS-CoV-2 papain-like protease inhibitor with antiviral efficacy in a mouse model; Science, 383:1434-1440, 2024; DOI: 10.1126/science.adm9724

Experimental method

X-RAY DIFFRACTION (2.8 Å)