登録情報 | データベース: PDB / ID: 5myk |
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タイトル | Structure of Pyroglutamate-Abeta-specific Fab c#17 in complex with murine Abeta-pE3-18PEGb |
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要素 | - Amyloid beta A4 protein
- Fab c#17 heavy chain
- Fab c#17 light chain
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キーワード | IMMUNE SYSTEM (免疫系) / Alzheimer's disease (アルツハイマー病) / pyroglutamate Abeta / monoclonal antibody (モノクローナル抗体) / fibrillation |
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機能・相同性 | 機能・相同性情報
positive regulation of protein import / regulation of response to calcium ion / regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway / positive regulation of response to endoplasmic reticulum stress / Formyl peptide receptors bind formyl peptides and many other ligands / amyloid-beta complex / positive regulation of G protein-coupled receptor internalization / growth cone lamellipodium / Advanced glycosylation endproduct receptor signaling / cellular response to norepinephrine stimulus ...positive regulation of protein import / regulation of response to calcium ion / regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway / positive regulation of response to endoplasmic reticulum stress / Formyl peptide receptors bind formyl peptides and many other ligands / amyloid-beta complex / positive regulation of G protein-coupled receptor internalization / growth cone lamellipodium / Advanced glycosylation endproduct receptor signaling / cellular response to norepinephrine stimulus / growth cone filopodium / endosome to plasma membrane transport vesicle / ECM proteoglycans / regulation of dendritic spine maintenance / negative regulation of blood circulation / リポタンパク質 / Insertion of tail-anchored proteins into the endoplasmic reticulum membrane / intermediate-density lipoprotein particle / positive regulation of endothelin production / TRAF6 mediated NF-kB activation / regulation of amyloid-beta clearance / Lysosome Vesicle Biogenesis / protein trimerization / Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) / Post-translational protein phosphorylation / G alpha (q) signalling events / TAK1-dependent IKK and NF-kappa-B activation / regulation of amyloid fibril formation / G alpha (i) signalling events / response to yeast / Platelet degranulation / low-density lipoprotein particle / very-low-density lipoprotein particle / peptidase activator activity / growth factor receptor binding / RAGE receptor binding / positive regulation of G protein-coupled receptor signaling pathway / high-density lipoprotein particle / astrocyte projection / antifungal humoral response / heparan sulfate proteoglycan binding / ion binding / : / positive regulation of membrane protein ectodomain proteolysis / frizzled binding / signaling receptor activator activity / cytosolic mRNA polyadenylation / collateral sprouting in absence of injury / microglia development / regulation of synapse structure or activity / axo-dendritic transport / acetylcholine receptor binding / synaptic assembly at neuromuscular junction / smooth endoplasmic reticulum calcium ion homeostasis / axon midline choice point recognition / positive regulation of extrinsic apoptotic signaling pathway / astrocyte activation involved in immune response / positive regulation of monocyte chemotaxis / regulation of spontaneous synaptic transmission / negative regulation of protein localization to nucleus / mating behavior / positive regulation of amyloid fibril formation / 繊毛 / main axon / PTB domain binding / Golgi-associated vesicle / neuron remodeling / presynaptic active zone / nuclear envelope lumen / regulation of toll-like receptor signaling pathway / modulation of excitatory postsynaptic potential / suckling behavior / COPII-coated ER to Golgi transport vesicle / dendrite development / neuronal dense core vesicle / chemoattractant activity / 小胞体 / positive regulation of protein kinase A signaling / apolipoprotein binding / negative regulation of long-term synaptic potentiation / positive regulation of excitatory postsynaptic potential / 学習 / neuromuscular process controlling balance / regulation of presynapse assembly / intracellular copper ion homeostasis / transition metal ion binding / regulation of multicellular organism growth / negative regulation of neuron differentiation / spindle midzone / positive regulation of T cell migration / positive regulation of cAMP-mediated signaling / positive regulation of calcium-mediated signaling / forebrain development / regulation of peptidyl-tyrosine phosphorylation / positive regulation of chemokine production / クラスリン / Notchシグナリング / cholesterol metabolic process / adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway / positive regulation of G2/M transition of mitotic cell cycle類似検索 - 分子機能 Amyloidogenic glycoprotein, copper-binding / Amyloidogenic glycoprotein, copper-binding domain conserved site / Amyloidogenic glycoprotein, copper-binding domain superfamily / Copper-binding of amyloid precursor, CuBD / Amyloid precursor protein (APP) copper-binding (CuBD) domain signature. / Beta-amyloid peptide (beta-APP) / Amyloidogenic glycoprotein, amyloid-beta peptide / Beta-amyloid precursor protein C-terminal / Amyloidogenic glycoprotein, intracellular domain, conserved site / Beta-amyloid precursor protein C-terminus ...Amyloidogenic glycoprotein, copper-binding / Amyloidogenic glycoprotein, copper-binding domain conserved site / Amyloidogenic glycoprotein, copper-binding domain superfamily / Copper-binding of amyloid precursor, CuBD / Amyloid precursor protein (APP) copper-binding (CuBD) domain signature. / Beta-amyloid peptide (beta-APP) / Amyloidogenic glycoprotein, amyloid-beta peptide / Beta-amyloid precursor protein C-terminal / Amyloidogenic glycoprotein, intracellular domain, conserved site / Beta-amyloid precursor protein C-terminus / Amyloid precursor protein (APP) intracellular domain signature. / Amyloid precursor protein (APP) E1 domain profile. / Amyloid precursor protein (APP) E2 domain profile. / Amyloidogenic glycoprotein, extracellular / Amyloidogenic glycoprotein, heparin-binding / Amyloidogenic glycoprotein, E2 domain / E2 domain superfamily / Amyloidogenic glycoprotein, heparin-binding domain superfamily / Amyloid A4 N-terminal heparin-binding / E2 domain of amyloid precursor protein / amyloid A4 / Amyloidogenic glycoprotein / Proteinase inhibitor I2, Kunitz, conserved site / Pancreatic trypsin inhibitor (Kunitz) family signature. / BPTI/Kunitz family of serine protease inhibitors. / Pancreatic trypsin inhibitor Kunitz domain / Kunitz/Bovine pancreatic trypsin inhibitor domain / Pancreatic trypsin inhibitor (Kunitz) family profile. / Pancreatic trypsin inhibitor Kunitz domain superfamily / PH-like domain superfamily / 抗体 / Immunoglobulin-like / サンドイッチ / Mainly Beta類似検索 - ドメイン・相同性 |
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生物種 | Mus musculus (ハツカネズミ) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.6 Å |
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データ登録者 | Parthier, C. / Piechotta, A. / Stubbs, M.T. |
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引用 | ジャーナル: J. Biol. Chem. / 年: 2017 タイトル: Structural and functional analyses of pyroglutamate-amyloid-beta-specific antibodies as a basis for Alzheimer immunotherapy. 著者: Piechotta, A. / Parthier, C. / Kleinschmidt, M. / Gnoth, K. / Pillot, T. / Lues, I. / Demuth, H.U. / Schilling, S. / Rahfeld, J.U. / Stubbs, M.T. |
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履歴 | 登録 | 2017年1月26日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2017年6月28日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2017年8月9日 | Group: Database references / カテゴリ: citation Item: _citation.journal_volume / _citation.page_first / _citation.page_last |
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改定 2.0 | 2020年3月11日 | Group: Atomic model / Data collection / Polymer sequence / カテゴリ: atom_site / entity_poly / pdbx_nonpoly_scheme Item: _atom_site.B_iso_or_equiv / _atom_site.Cartn_x ..._atom_site.B_iso_or_equiv / _atom_site.Cartn_x / _atom_site.Cartn_y / _atom_site.Cartn_z / _entity_poly.pdbx_seq_one_letter_code_can / _pdbx_nonpoly_scheme.auth_seq_num |
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改定 2.1 | 2024年1月17日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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