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Structure paper

TitleStructural and functional analyses of pyroglutamate-amyloid-beta-specific antibodies as a basis for Alzheimer immunotherapy.
Journal, issue, pagesJ. Biol. Chem., Vol. 292, Page 12713-12724, Year 2017
Publish dateJan 25, 2017 (structure data deposition date)
AuthorsPiechotta, A. / Parthier, C. / Kleinschmidt, M. / Gnoth, K. / Pillot, T. / Lues, I. / Demuth, H.U. / Schilling, S. / Rahfeld, J.U. / Stubbs, M.T.
External linksJ. Biol. Chem. / PubMed:28623233
MethodsX-ray diffraction
Resolution1.492 - 2.211 Å
Structure data

PDB-5my4:
Structure of Pyroglutamate-Abeta-specific Fab c#17 in complex with human Abeta-pE3-12PEGb
Method: X-RAY DIFFRACTION / Resolution: 2.211 Å

PDB-5myk:
Structure of Pyroglutamate-Abeta-specific Fab c#17 in complex with murine Abeta-pE3-18PEGb
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

PDB-5myo:
Structure of Pyroglutamate-Abeta-specific Fab c#6 in complex with human Abeta-pE3-12-PEGb
Method: X-RAY DIFFRACTION / Resolution: 1.59 Å

PDB-5myx:
Structure of Pyroglutamate-Abeta-specific Fab c#24 in complex with human Abeta-pE3-18
Method: X-RAY DIFFRACTION / Resolution: 1.492 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-SO4:
SULFATE ION

ChemComp-GOL:
GLYCEROL

Source
  • mus musculus (house mouse)
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Alzheimer's disease / pyroglutamate Abeta / monoclonal antibody / fibrillation

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