Entry Database : PDB / ID : 4e4d Structure visualization Downloads & linksTitle Crystal structure of mouse RANKL-OPG complex ComponentsTumor necrosis factor ligand superfamily member 11, soluble form Tumor necrosis factor receptor superfamily member 11B DetailsKeywords Cytokine/Signaling Protein / TNF-Related Activation-Induced Cytokine-Receptor / Cysteine-Rich Domain / Jelly-Roll Fold / Cytokine-Signaling Protein complexFunction / homology Function and homology informationFunction Domain/homology Component
negative regulation of odontogenesis of dentin-containing tooth / positive regulation of corticotropin-releasing hormone secretion / positive regulation of fever generation by positive regulation of prostaglandin secretion / tooth eruption / positive regulation of osteoclast development / TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway / osteoclast proliferation / TNFs bind their physiological receptors / tumor necrosis factor receptor superfamily binding / TNFR2 non-canonical NF-kB pathway ... negative regulation of odontogenesis of dentin-containing tooth / positive regulation of corticotropin-releasing hormone secretion / positive regulation of fever generation by positive regulation of prostaglandin secretion / tooth eruption / positive regulation of osteoclast development / TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway / osteoclast proliferation / TNFs bind their physiological receptors / tumor necrosis factor receptor superfamily binding / TNFR2 non-canonical NF-kB pathway / response to xenobiotic stimulus => GO:0009410 / positive regulation of homotypic cell-cell adhesion / regulation of osteoclast differentiation / paracrine signaling / response to arsenic-containing substance / positive regulation of osteoclast differentiation / tumor necrosis factor receptor binding / negative regulation of bone resorption / osteoclast development / mammary gland epithelial cell proliferation / monocyte chemotaxis / response to magnesium ion / mammary gland alveolus development / positive regulation of bone resorption / calcium ion homeostasis / lymph node development / positive regulation of phosphorylation / JNK cascade / bone resorption / tumor necrosis factor-mediated signaling pathway / ERK1 and ERK2 cascade / ossification / extracellular matrix organization / response to nutrient / phosphatidylinositol 3-kinase/protein kinase B signal transduction / osteoclast differentiation / extracellular matrix / cellular response to leukemia inhibitory factor / cytokine activity / calcium-mediated signaling / animal organ morphogenesis / positive regulation of JNK cascade / bone development / positive regulation of DNA-binding transcription factor activity / response to estrogen / positive regulation of T cell activation / positive regulation of canonical NF-kappaB signal transduction / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / receptor ligand activity / positive regulation of ERK1 and ERK2 cascade / immune response / apoptotic process / positive regulation of gene expression / negative regulation of transcription by RNA polymerase II / signal transduction / positive regulation of transcription by RNA polymerase II / extracellular space / identical protein binding / plasma membrane / cytoplasm Similarity search - Function Tumour necrosis factor receptor 11B / Tumour necrosis factor receptor 11 / Tumour necrosis factor ligand 10/11 / Tumor Necrosis Factor Receptor, subunit A, domain 2 / Tumor Necrosis Factor Receptor, subunit A; domain 2 / Tumour necrosis factor family. / Tyrosine-protein kinase ephrin type A/B receptor-like / TNF(Tumour Necrosis Factor) family / Tumour necrosis factor domain / TNFR/NGFR family cysteine-rich region domain profile. ... Tumour necrosis factor receptor 11B / Tumour necrosis factor receptor 11 / Tumour necrosis factor ligand 10/11 / Tumor Necrosis Factor Receptor, subunit A, domain 2 / Tumor Necrosis Factor Receptor, subunit A; domain 2 / Tumour necrosis factor family. / Tyrosine-protein kinase ephrin type A/B receptor-like / TNF(Tumour Necrosis Factor) family / Tumour necrosis factor domain / TNFR/NGFR family cysteine-rich region domain profile. / TNFR/NGFR cysteine-rich region / TNFR/NGFR family cysteine-rich region signature. / Tumor necrosis factor (TNF) homology domain (THD) profile. / Tumor necrosis factor receptor / nerve growth factor receptor repeats. / TNFR/NGFR cysteine-rich region / Jelly Rolls - #40 / Tumour necrosis factor-like domain superfamily / Putative ephrin-receptor like / Death domain profile. / DEATH domain, found in proteins involved in cell death (apoptosis). / Death domain / Death domain / Death-like domain superfamily / Ribbon / Jelly Rolls / Sandwich / Mainly Beta Similarity search - Domain/homologyBiological species Mus musculus (house mouse)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.7 Å DetailsAuthors Nelson, C.A. / Fremont, D.H. CitationJournal : Structure / Year : 2012Title : RANKL Employs Distinct Binding Modes to Engage RANK and the Osteoprotegerin Decoy Receptor.Authors : Nelson, C.A. / Warren, J.T. / Wang, M.W. / Teitelbaum, S.L. / Fremont, D.H. History Deposition Mar 12, 2012 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Oct 24, 2012 Provider : repository / Type : Initial releaseRevision 1.1 Dec 12, 2012 Group : Database referencesRevision 1.2 Nov 15, 2017 Group : Refinement description / Category : softwareItem : _software.classification / _software.contact_author ... _software.classification / _software.contact_author / _software.contact_author_email / _software.date / _software.language / _software.location / _software.name / _software.type / _software.version Revision 1.3 Sep 13, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ref_seq_dif / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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