Entry Database : PDB / ID : 4giq Structure visualization Downloads & linksTitle Crystal Structure of mouse RANK bound to RANKL Components(Tumor necrosis factor ...) x 2 Details Keywords PROTEIN BINDING/PROTEIN BINDING / RANK / ODFR / Activation-Induced Cytokine-Receptor / TNFRSF11A / RANKL / OPGL / TNF-like Cytokine / Cysteine-Rich Domain / Jelly-Roll fold / PROTEIN BINDING-PROTEIN BINDING complexFunction / homology Function and homology informationFunction Domain/homology Component
multinuclear osteoclast differentiation / positive regulation of corticotropin-releasing hormone secretion / positive regulation of fever generation by positive regulation of prostaglandin secretion / tooth eruption / positive regulation of osteoclast development / TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway / osteoclast proliferation / TNFs bind their physiological receptors / circadian temperature homeostasis / tumor necrosis factor receptor superfamily binding ... multinuclear osteoclast differentiation / positive regulation of corticotropin-releasing hormone secretion / positive regulation of fever generation by positive regulation of prostaglandin secretion / tooth eruption / positive regulation of osteoclast development / TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway / osteoclast proliferation / TNFs bind their physiological receptors / circadian temperature homeostasis / tumor necrosis factor receptor superfamily binding / tumor necrosis factor receptor activity / TNFR2 non-canonical NF-kB pathway / positive regulation of homotypic cell-cell adhesion / regulation of osteoclast differentiation / cellular response to zinc ion starvation / paracrine signaling / positive regulation of osteoclast differentiation / tumor necrosis factor receptor binding / osteoclast development / mammary gland epithelial cell proliferation / cytokine binding / monocyte chemotaxis / mammary gland alveolus development / positive regulation of bone resorption / calcium ion homeostasis / response to tumor necrosis factor / lymph node development / response to mechanical stimulus / positive regulation of phosphorylation / JNK cascade / bone resorption / tumor necrosis factor-mediated signaling pathway / ERK1 and ERK2 cascade / response to interleukin-1 / ossification / phosphatidylinositol 3-kinase/protein kinase B signal transduction / osteoclast differentiation / cellular response to leukemia inhibitory factor / cytokine activity / calcium-mediated signaling / animal organ morphogenesis / positive regulation of JNK cascade / response to insulin / bone development / response to organic cyclic compound / positive regulation of DNA-binding transcription factor activity / positive regulation of T cell activation / positive regulation of canonical NF-kappaB signal transduction / response to ethanol / adaptive immune response / response to lipopolysaccharide / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / receptor ligand activity / positive regulation of ERK1 and ERK2 cascade / immune response / membrane raft / external side of plasma membrane / positive regulation of gene expression / negative regulation of transcription by RNA polymerase II / cell surface / positive regulation of transcription by RNA polymerase II / extracellular space / identical protein binding / metal ion binding / plasma membrane / cytoplasm / cytosol Similarity search - Function Tumour necrosis factor receptor 11A / Tumor necrosis factor receptor 11A, N-terminal / Rank, cysteine-rich repeat domain 2 / Receptor activator of the NF-KB cysteine-rich repeat domain 2 / Tumour necrosis factor receptor 11 / Tumour necrosis factor ligand 10/11 / Tumor Necrosis Factor Receptor, subunit A, domain 2 / Tumor Necrosis Factor Receptor, subunit A; domain 2 / Tumour necrosis factor family. / TNF(Tumour Necrosis Factor) family ... Tumour necrosis factor receptor 11A / Tumor necrosis factor receptor 11A, N-terminal / Rank, cysteine-rich repeat domain 2 / Receptor activator of the NF-KB cysteine-rich repeat domain 2 / Tumour necrosis factor receptor 11 / Tumour necrosis factor ligand 10/11 / Tumor Necrosis Factor Receptor, subunit A, domain 2 / Tumor Necrosis Factor Receptor, subunit A; domain 2 / Tumour necrosis factor family. / TNF(Tumour Necrosis Factor) family / Tumour necrosis factor domain / TNFR/NGFR family cysteine-rich region domain profile. / TNFR/NGFR cysteine-rich region / TNFR/NGFR family cysteine-rich region signature. / Tumor necrosis factor (TNF) homology domain (THD) profile. / Tumor necrosis factor receptor / nerve growth factor receptor repeats. / TNFR/NGFR cysteine-rich region / Jelly Rolls - #40 / Tumour necrosis factor-like domain superfamily / Ribbon / Jelly Rolls / Sandwich / Mainly Beta Similarity search - Domain/homologyBiological species Mus musculus (house mouse)Method X-RAY DIFFRACTION / MOLECULAR REPLACEMENT / molecular replacement / Resolution : 2.7 Å DetailsAuthors Nelson, C.A. / Wang, M.W.-H. / Fremont, D.H. CitationJournal : Structure / Year : 2012Title : RANKL Employs Distinct Binding Modes to Engage RANK and the Osteoprotegerin Decoy Receptor.Authors : Nelson, C.A. / Warren, J.T. / Wang, M.W. / Teitelbaum, S.L. / Fremont, D.H. History Deposition Aug 8, 2012 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Oct 24, 2012 Provider : repository / Type : Initial releaseRevision 1.1 Nov 28, 2012 Group : Database referencesRevision 1.2 Feb 13, 2013 Group : OtherRevision 1.3 Nov 15, 2017 Group : Refinement description / Category : software / Item : _software.nameRevision 1.4 Jul 29, 2020 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Structure summary Category : chem_comp / entity ... chem_comp / entity / pdbx_chem_comp_identifier / pdbx_entity_nonpoly / pdbx_struct_conn_angle / struct_conn / struct_ref_seq_dif / struct_site / struct_site_gen Item : _chem_comp.name / _chem_comp.type ... _chem_comp.name / _chem_comp.type / _entity.pdbx_description / _pdbx_entity_nonpoly.name / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.pdbx_role / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_ref_seq_dif.details Description : Carbohydrate remediation / Provider : repository / Type : RemediationRevision 1.5 Sep 13, 2023 Group : Data collection / Database references ... Data collection / Database references / Refinement description / Structure summary Category : chem_comp / chem_comp_atom ... chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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