Entry Database : PDB / ID : 5bnq Structure visualization Downloads & linksTitle Crystal structure of hRANKL-mRANK complex Components(Tumor necrosis factor ...) x 2 Details Keywords CYTOKINE / RANK / RANKL / RANKL-RANK complex / TNFSF11 / TNFRSF11a / TNF superfamilyFunction / homology Function and homology informationFunction Domain/homology Component
: / : / multinuclear osteoclast differentiation / positive regulation of corticotropin-releasing hormone secretion / positive regulation of fever generation by positive regulation of prostaglandin secretion / tooth eruption / positive regulation of osteoclast development / TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway / osteoclast proliferation / circadian temperature homeostasis ... : / : / multinuclear osteoclast differentiation / positive regulation of corticotropin-releasing hormone secretion / positive regulation of fever generation by positive regulation of prostaglandin secretion / tooth eruption / positive regulation of osteoclast development / TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway / osteoclast proliferation / circadian temperature homeostasis / tumor necrosis factor receptor superfamily binding / tumor necrosis factor receptor activity / TNFR2 non-canonical NF-kB pathway / TNFs bind their physiological receptors / TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway / positive regulation of homotypic cell-cell adhesion / cellular response to zinc ion starvation / paracrine signaling / positive regulation of osteoclast differentiation / tumor necrosis factor receptor binding / positive regulation of intracellular signal transduction / osteoclast development / mammary gland epithelial cell proliferation / cytokine binding / monocyte chemotaxis / mammary gland alveolus development / positive regulation of bone resorption / calcium ion homeostasis / response to tumor necrosis factor / lymph node development / response to mechanical stimulus / JNK cascade / bone resorption / tumor necrosis factor-mediated signaling pathway / ERK1 and ERK2 cascade / response to interleukin-1 / ossification / phosphatidylinositol 3-kinase/protein kinase B signal transduction / osteoclast differentiation / cellular response to leukemia inhibitory factor / cytokine activity / TNFR2 non-canonical NF-kB pathway / calcium-mediated signaling / positive regulation of JNK cascade / positive regulation of MAP kinase activity / response to insulin / response to organic cyclic compound / cytokine-mediated signaling pathway / positive regulation of DNA-binding transcription factor activity / positive regulation of T cell activation / positive regulation of NF-kappaB transcription factor activity / positive regulation of canonical NF-kappaB signal transduction / response to ethanol / adaptive immune response / response to lipopolysaccharide / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / positive regulation of ERK1 and ERK2 cascade / immune response / membrane raft / external side of plasma membrane / positive regulation of gene expression / negative regulation of transcription by RNA polymerase II / cell surface / positive regulation of transcription by RNA polymerase II / extracellular space / extracellular region / identical protein binding / metal ion binding / plasma membrane / cytoplasm / cytosol Similarity search - Function Tumour necrosis factor receptor 11A / Tumor necrosis factor receptor 11A, N-terminal / Rank, cysteine-rich repeat domain 2 / Receptor activator of the NF-KB cysteine-rich repeat domain 2 / Tumour necrosis factor receptor 11 / Tumour necrosis factor ligand 10/11 / Tumor Necrosis Factor Receptor, subunit A, domain 2 / Tumor Necrosis Factor Receptor, subunit A; domain 2 / Tumour necrosis factor family. / TNF(Tumour Necrosis Factor) family ... Tumour necrosis factor receptor 11A / Tumor necrosis factor receptor 11A, N-terminal / Rank, cysteine-rich repeat domain 2 / Receptor activator of the NF-KB cysteine-rich repeat domain 2 / Tumour necrosis factor receptor 11 / Tumour necrosis factor ligand 10/11 / Tumor Necrosis Factor Receptor, subunit A, domain 2 / Tumor Necrosis Factor Receptor, subunit A; domain 2 / Tumour necrosis factor family. / TNF(Tumour Necrosis Factor) family / Tumour necrosis factor domain / TNFR/NGFR family cysteine-rich region domain profile. / TNFR/NGFR cysteine-rich region / TNFR/NGFR family cysteine-rich region signature. / Tumor necrosis factor (TNF) homology domain (THD) profile. / Tumor necrosis factor receptor / nerve growth factor receptor repeats. / TNFR/NGFR cysteine-rich region / Jelly Rolls - #40 / Tumour necrosis factor-like domain superfamily / Ribbon / Jelly Rolls / Sandwich / Mainly Beta Similarity search - Domain/homology PHOSPHATE ION / Tumor necrosis factor ligand superfamily member 11 / Tumor necrosis factor receptor superfamily member 11A Similarity search - ComponentBiological species Homo sapiens (human)Mus musculus (house mouse)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.8 Å DetailsAuthors Ren, J. CitationJournal : Sci Rep / Year : 2015Title : A RANKL mutant used as an inter-species vaccine for efficient immunotherapy of osteoporosis.Authors : Liu, C. / Zhao, Y. / He, W. / Wang, W. / Chen, Y. / Zhang, S. / Ma, Y. / Gohda, J. / Ishida, T. / Walter, T.S. / Owens, R.J. / Stuart, D.I. / Ren, J. / Gao, B. History Deposition May 26, 2015 Deposition site : RCSB / Processing site : PDBERevision 1.0 Oct 14, 2015 Provider : repository / Type : Initial releaseRevision 1.1 Jan 10, 2024 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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