登録情報 データベース : PDB / ID : 4b1e 構造の表示 ダウンロードとリンクタイトル New Aminoimidazoles as BACE-1 Inhibitors: From Rational Design to Ab- lowering in Brain 要素BETA-SECRETASE 1 詳細 キーワード HYDROLASE / STRUCTURE-BASED DRUG DESIGN機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
memapsin 2 / Golgi-associated vesicle lumen / signaling receptor ligand precursor processing / beta-aspartyl-peptidase activity / amyloid precursor protein catabolic process / amyloid-beta formation / membrane protein ectodomain proteolysis / cellular response to manganese ion / amyloid-beta metabolic process / prepulse inhibition ... memapsin 2 / Golgi-associated vesicle lumen / signaling receptor ligand precursor processing / beta-aspartyl-peptidase activity / amyloid precursor protein catabolic process / amyloid-beta formation / membrane protein ectodomain proteolysis / cellular response to manganese ion / amyloid-beta metabolic process / prepulse inhibition / detection of mechanical stimulus involved in sensory perception of pain / protein serine/threonine kinase binding / cellular response to copper ion / presynaptic modulation of chemical synaptic transmission / multivesicular body / hippocampal mossy fiber to CA3 synapse / response to lead ion / trans-Golgi network / recycling endosome / protein processing / cellular response to amyloid-beta / positive regulation of neuron apoptotic process / late endosome / synaptic vesicle / peptidase activity / amyloid-beta binding / endopeptidase activity / amyloid fibril formation / aspartic-type endopeptidase activity / early endosome / lysosome / endosome membrane / endosome / membrane raft / Amyloid fiber formation / endoplasmic reticulum lumen / axon / neuronal cell body / dendrite / Golgi apparatus / enzyme binding / cell surface / proteolysis / membrane / plasma membrane 類似検索 - 分子機能 Beta-secretase BACE1 / Beta-secretase BACE / Memapsin-like / Eukaryotic aspartyl protease / Aspartic peptidase A1 family / Peptidase family A1 domain / Peptidase family A1 domain profile. / Cathepsin D, subunit A; domain 1 / Acid Proteases / Aspartic peptidase, active site ... Beta-secretase BACE1 / Beta-secretase BACE / Memapsin-like / Eukaryotic aspartyl protease / Aspartic peptidase A1 family / Peptidase family A1 domain / Peptidase family A1 domain profile. / Cathepsin D, subunit A; domain 1 / Acid Proteases / Aspartic peptidase, active site / Eukaryotic and viral aspartyl proteases active site. / Aspartic peptidase domain superfamily / Beta Barrel / Mainly Beta 類似検索 - ドメイン・相同性生物種 HOMO SAPIENS (ヒト)手法 X線回折 / 分子置換 / 解像度 : 1.95 Å 詳細データ登録者 Rahm, F. / Blid, J. / Ginman, T. / Karlstrom, S. / Kihlstrom, J. / Kolmodin, K. / Lindstrom, J. / von Berg, S. / von Kieseritzky, F. / Slivo, C. ...Rahm, F. / Blid, J. / Ginman, T. / Karlstrom, S. / Kihlstrom, J. / Kolmodin, K. / Lindstrom, J. / von Berg, S. / von Kieseritzky, F. / Slivo, C. / Swahn, B. / Viklund, J. / Olsson, L. / Johansson, P. / Eketjall, S. / Falting, J. / Jeppsson, F. / Stromberg, K. / Janson, J. / Gravenfors, Y. 引用ジャーナル : J. Med. Chem. / 年 : 2012タイトル : New aminoimidazoles as beta-secretase (BACE-1) inhibitors showing amyloid-beta (A beta ) lowering in brain.著者: Gravenfors, Y. / Viklund, J. / Blid, J. / Ginman, T. / Karlstrom, S. / Kihlstrom, J. / Kolmodin, K. / Lindstrom, J. / von Berg, S. / von Kieseritzky, F. / Bogar, K. / Slivo, C. / Swahn, B.M. ... 著者 : Gravenfors, Y. / Viklund, J. / Blid, J. / Ginman, T. / Karlstrom, S. / Kihlstrom, J. / Kolmodin, K. / Lindstrom, J. / von Berg, S. / von Kieseritzky, F. / Bogar, K. / Slivo, C. / Swahn, B.M. / Olsson, L.L. / Johansson, P. / Eketjall, S. / Falting, J. / Jeppsson, F. / Stromberg, K. / Janson, J. / Rahm, F. 履歴 登録 2012年7月10日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2012年10月10日 Provider : repository / タイプ : Initial release改定 1.1 2012年11月21日 Group : Database references改定 1.2 2018年2月14日 Group : Database references / Structure summary / カテゴリ : audit_author / citation / citation_authorItem : _audit_author.name / _citation.journal_abbrev ... _audit_author.name / _citation.journal_abbrev / _citation.journal_id_ISSN / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.title
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