SHEET THE SHEET STRUCTURE OF THIS MOLECULE IS BIFURCATED. IN ORDER TO REPRESENT THIS FEATURE IN ... SHEET THE SHEET STRUCTURE OF THIS MOLECULE IS BIFURCATED. IN ORDER TO REPRESENT THIS FEATURE IN THE SHEET RECORDS BELOW, TWO SHEETS ARE DEFINED.
Mass: 18.015 Da / Num. of mol.: 140 / Source method: isolated from a natural source / Formula: H2O
Compound details
ENGINEERED MUTATION IN CHAIN A ARG 56 LYS AND ARG 57 LYS CATALYTIC ACTIVITY: BROAD ENDOPEPTIDASE ...ENGINEERED MUTATION IN CHAIN A ARG 56 LYS AND ARG 57 LYS CATALYTIC ACTIVITY: BROAD ENDOPEPTIDASE SPECIFICITY. CLEAVES GLU- VAL-ASN-LEU-|-ASP-ALA-GLU-PHE IN THE SWEDISH VARIANT OF ALZHEIMER'S AMYLOID PRECURSOR PROTEIN.
Sequence details
RESIDUES 56 AND 57 FROM THE UNIPROT REFERENCE BELOW HAVE HAVE BEEN MUTATED TO LYS FROM ARG. SINCE ...RESIDUES 56 AND 57 FROM THE UNIPROT REFERENCE BELOW HAVE HAVE BEEN MUTATED TO LYS FROM ARG. SINCE THIS MUTATION IS NOT VISIBLE IN THE STRUCTURE, THERE ARE NO SEQADV RECORDS GIVEN BELOW.
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Experimental details
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Experiment
Experiment
Method: X-RAY DIFFRACTION / Number of used crystals: 1
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Sample preparation
Crystal
Density Matthews: 2.77 Å3/Da / Density % sol: 55.62 %
Resolution: 2.55→39.2 Å / Cor.coef. Fo:Fc: 0.931 / Cor.coef. Fo:Fc free: 0.891 / SU B: 11.51 / SU ML: 0.247 / Cross valid method: THROUGHOUT / ESU R: 0.491 / ESU R Free: 0.325 / Stereochemistry target values: MAXIMUM LIKELIHOOD / Details: HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS.
Rfactor
Num. reflection
% reflection
Selection details
Rfree
0.288
890
5.1 %
RANDOM
Rwork
0.216
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obs
0.219
16609
99.4 %
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Solvent computation
Ion probe radii: 0.8 Å / Shrinkage radii: 0.8 Å / VDW probe radii: 1.4 Å / Solvent model: BABINET MODEL WITH MASK