登録情報 データベース : PDB / ID : 2wf0 構造の表示 ダウンロードとリンクタイトル Human BACE-1 in complex with 4-ethyl-N-((1S,2R)-2-hydroxy-1-(phenylmethyl)-3-(((3-(trifluoromethyl)phenyl)methyl)amino)propyl)-8-(2-oxo-1-pyrrolidinyl)-6-quinolinecarboxamide 要素BETA-SECRETASE 1 詳細 キーワード HYDROLASE / MEMAPSIN-2 / POLYMORPHISM / GLYCOPROTEIN / ASP-2 / BACE-1 / ZYMOGEN / PROTEASE / MEMBRANE / TRANSMEMBRANE / BETA-SECRETASE / DISULFIDE BOND / ASPARTYL PROTEASE / ALTERNATIVE SPLICING / BETA-SITE APP CLEAVING ENZYME機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
memapsin 2 / Golgi-associated vesicle lumen / beta-aspartyl-peptidase activity / signaling receptor ligand precursor processing / amyloid-beta formation / amyloid precursor protein catabolic process / membrane protein ectodomain proteolysis / amyloid-beta metabolic process / cellular response to manganese ion / detection of mechanical stimulus involved in sensory perception of pain ... memapsin 2 / Golgi-associated vesicle lumen / beta-aspartyl-peptidase activity / signaling receptor ligand precursor processing / amyloid-beta formation / amyloid precursor protein catabolic process / membrane protein ectodomain proteolysis / amyloid-beta metabolic process / cellular response to manganese ion / detection of mechanical stimulus involved in sensory perception of pain / prepulse inhibition / cellular response to copper ion / multivesicular body / presynaptic modulation of chemical synaptic transmission / protein serine/threonine kinase binding / hippocampal mossy fiber to CA3 synapse / trans-Golgi network / response to lead ion / recycling endosome / protein processing / cellular response to amyloid-beta / late endosome / synaptic vesicle / peptidase activity / positive regulation of neuron apoptotic process / amyloid-beta binding / endopeptidase activity / amyloid fibril formation / aspartic-type endopeptidase activity / early endosome / lysosome / endosome membrane / endosome / Amyloid fiber formation / membrane raft / endoplasmic reticulum lumen / axon / neuronal cell body / dendrite / enzyme binding / cell surface / Golgi apparatus / proteolysis / membrane / plasma membrane 類似検索 - 分子機能 Beta-secretase BACE1 / Beta-secretase BACE / Memapsin-like / Eukaryotic aspartyl protease / Aspartic peptidase A1 family / Peptidase family A1 domain / Peptidase family A1 domain profile. / Cathepsin D, subunit A; domain 1 / Acid Proteases / Aspartic peptidase, active site ... Beta-secretase BACE1 / Beta-secretase BACE / Memapsin-like / Eukaryotic aspartyl protease / Aspartic peptidase A1 family / Peptidase family A1 domain / Peptidase family A1 domain profile. / Cathepsin D, subunit A; domain 1 / Acid Proteases / Aspartic peptidase, active site / Eukaryotic and viral aspartyl proteases active site. / Aspartic peptidase domain superfamily / Beta Barrel / Mainly Beta 類似検索 - ドメイン・相同性生物種 HOMO SAPIENS (ヒト)手法 X線回折 / シンクロトロン / OTHER / 解像度 : 1.6 Å 詳細データ登録者 Charrier, N. / Clarke, B. / Cutler, L. / Demont, E. / Dingwall, C. / Dunsdon, R. / Hawkins, J. / Howes, C. / Hubbard, J. / Hussain, I. ...Charrier, N. / Clarke, B. / Cutler, L. / Demont, E. / Dingwall, C. / Dunsdon, R. / Hawkins, J. / Howes, C. / Hubbard, J. / Hussain, I. / Maile, G. / Matico, R. / Mosley, J. / Naylor, A. / O'Brien, A. / Redshaw, S. / Rowland, P. / Soleil, V. / Smith, K.J. / Sweitzer, S. / Theobald, P. / Vesey, D. / Walter, D.S. / Wayne, G. 引用ジャーナル : Bioorg.Med.Chem.Lett. / 年 : 2009タイトル : Second Generation of Bace-1 Inhibitors. Part 1: The Need for Improved Pharmacokinetics.著者: Charrier, N. / Clarke, B. / Cutler, L. / Demont, E. / Dingwall, C. / Dunsdon, R. / Hawkins, J. / Howes, C. / Hubbard, J. / Hussain, I. / Maile, G. / Matico, R. / Mosley, J. / Naylor, A. / ... 著者 : Charrier, N. / Clarke, B. / Cutler, L. / Demont, E. / Dingwall, C. / Dunsdon, R. / Hawkins, J. / Howes, C. / Hubbard, J. / Hussain, I. / Maile, G. / Matico, R. / Mosley, J. / Naylor, A. / O'Brien, A. / Redshaw, S. / Rowland, P. / Soleil, V. / Smith, K.J. / Sweitzer, S. / Theobald, P. / Vesey, D. / Walter, D.S. / Wayne, G. 履歴 登録 2009年4月2日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2009年5月19日 Provider : repository / タイプ : Initial release改定 1.1 2011年5月8日 Group : Version format compliance改定 1.2 2011年7月13日 Group : Version format compliance改定 1.3 2019年3月6日 Group : Data collection / Experimental preparation / Otherカテゴリ : exptl_crystal_grow / pdbx_database_proc / pdbx_database_statusItem : _exptl_crystal_grow.method / _pdbx_database_status.recvd_author_approval改定 1.4 2019年5月15日 Group : Data collection / Experimental preparation / カテゴリ : exptl_crystal_grow / Item : _exptl_crystal_grow.temp改定 1.5 2024年11月20日 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Other / Structure summary カテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_entry_details / pdbx_modification_feature / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _pdbx_entry_details.has_protein_modification / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
すべて表示 表示を減らす Remark 700 SHEET THE SHEET STRUCTURE OF THIS MOLECULE IS BIFURCATED. IN ORDER TO REPRESENT THIS FEATURE IN ... SHEET THE SHEET STRUCTURE OF THIS MOLECULE IS BIFURCATED. IN ORDER TO REPRESENT THIS FEATURE IN THE SHEET RECORDS BELOW, TWO SHEETS ARE DEFINED.