Entry Database : PDB / ID : 2ltx Structure visualization Downloads & linksTitle Smurf1 WW2 domain in complex with a Smad7 derived peptide ComponentsE3 ubiquitin-protein ligase SMURF1 Smad7 derived peptide DetailsKeywords PROTEIN BINDING/PEPTIDE / WW / SMURF1 / SMAD7 / PROTEIN BINDING-PEPTIDE complexFunction / homology Function and homology informationFunction Domain/homology Component
positive regulation of chondrocyte hypertrophy / substrate localization to autophagosome / negative regulation of T-helper 17 type immune response / engulfment of target by autophagosome / negative regulation of chondrocyte proliferation / negative regulation of T cell cytokine production / heteromeric SMAD protein complex / protein targeting to vacuole involved in autophagy / regulation of ventricular cardiac muscle cell membrane depolarization / positive regulation of cell-cell adhesion ... positive regulation of chondrocyte hypertrophy / substrate localization to autophagosome / negative regulation of T-helper 17 type immune response / engulfment of target by autophagosome / negative regulation of chondrocyte proliferation / negative regulation of T cell cytokine production / heteromeric SMAD protein complex / protein targeting to vacuole involved in autophagy / regulation of ventricular cardiac muscle cell membrane depolarization / positive regulation of cell-cell adhesion / negative regulation of T-helper 17 cell differentiation / response to laminar fluid shear stress / regulation of epithelial to mesenchymal transition / activin receptor binding / regulation of transforming growth factor beta receptor signaling pathway / ectoderm development / receptor catabolic process / transforming growth factor beta receptor binding / negative regulation of transcription by competitive promoter binding / negative regulation of ubiquitin-protein transferase activity / Signaling by BMP / type I transforming growth factor beta receptor binding / positive regulation of dendrite extension / adherens junction assembly / SMAD protein signal transduction / negative regulation of activin receptor signaling pathway / positive regulation of ubiquitin-dependent protein catabolic process / HECT-type E3 ubiquitin transferase / protein-containing complex localization / negative regulation of epithelial to mesenchymal transition / I-SMAD binding / negative regulation of ossification / transcription regulator inhibitor activity / Wnt signaling pathway, planar cell polarity pathway / ventricular cardiac muscle tissue morphogenesis / artery morphogenesis / ureteric bud development / ventricular septum morphogenesis / negative regulation of SMAD protein signal transduction / negative regulation of peptidyl-threonine phosphorylation / SMAD binding / negative regulation of peptidyl-serine phosphorylation / R-SMAD binding / ubiquitin-like ligase-substrate adaptor activity / negative regulation of BMP signaling pathway / regulation of cardiac muscle contraction / anatomical structure morphogenesis / positive regulation of axon extension / BMP signaling pathway / negative regulation of protein ubiquitination / cellular response to transforming growth factor beta stimulus / collagen binding / protein export from nucleus / negative regulation of cell migration / Downregulation of TGF-beta receptor signaling / transforming growth factor beta receptor signaling pathway / TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) / Asymmetric localization of PCP proteins / cellular response to leukemia inhibitory factor / protein localization to plasma membrane / Downregulation of SMAD2/3:SMAD4 transcriptional activity / SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription / negative regulation of transforming growth factor beta receptor signaling pathway / Hedgehog 'on' state / Regulation of RUNX3 expression and activity / phospholipid binding / fibrillar center / beta-catenin binding / protein polyubiquitination / ubiquitin-protein transferase activity / transcription corepressor activity / Regulation of RUNX2 expression and activity / UCH proteinases / Interferon gamma signaling / ubiquitin protein ligase activity / Antigen processing: Ubiquitination & Proteasome degradation / positive regulation of proteasomal ubiquitin-dependent protein catabolic process / ubiquitin-dependent protein catabolic process / proteasome-mediated ubiquitin-dependent protein catabolic process / cell differentiation / protein stabilization / Ub-specific processing proteases / protein ubiquitination / axon / centrosome / neuronal cell body / ubiquitin protein ligase binding / chromatin / regulation of transcription by RNA polymerase II / negative regulation of transcription by RNA polymerase II / protein-containing complex / extracellular exosome / nucleoplasm / nucleus / metal ion binding / plasma membrane / cytoplasm / cytosol Similarity search - Function MAD homology, MH1 / Dwarfin / SMAD MH1 domain superfamily / MAD homology domain 1 (MH1) profile. / SMAD domain, Dwarfin-type / MH2 domain / MAD homology domain 2 (MH2) profile. / Domain B in dwarfin family proteins / MAD homology 1, Dwarfin-type / MH1 domain ... MAD homology, MH1 / Dwarfin / SMAD MH1 domain superfamily / MAD homology domain 1 (MH1) profile. / SMAD domain, Dwarfin-type / MH2 domain / MAD homology domain 2 (MH2) profile. / Domain B in dwarfin family proteins / MAD homology 1, Dwarfin-type / MH1 domain / Domain A in dwarfin family proteins / E3 ubiquitin-protein ligase, SMURF1 type / SMAD-like domain superfamily / HECT domain / HECT, E3 ligase catalytic domain / HECT-domain (ubiquitin-transferase) / HECT domain profile. / Domain Homologous to E6-AP Carboxyl Terminus with / C2 domain / Protein kinase C conserved region 2 (CalB) / SMAD/FHA domain superfamily / WW domain / WW/rsp5/WWP domain signature. / C2 domain / C2 domain profile. / WW domain superfamily / WW/rsp5/WWP domain profile. / Domain with 2 conserved Trp (W) residues / WW domain / C2 domain superfamily Similarity search - Domain/homologyBiological species Homo sapiens (human)Method SOLUTION NMR / torsion angle dynamics DetailsAuthors Macias, M.J. / Aragon, E. / Goerner, N. / Xi, Q. / Lopes, T. / Gao, S. / Massague, J. CitationJournal : Structure / Year : 2012Title : Structural Basis for the Versatile Interactions of Smad7 with Regulator WW Domains in TGF-beta Pathways.Authors : Aragon, E. / Goerner, N. / Xi, Q. / Gomes, T. / Gao, S. / Massague, J. / Macias, M.J. History Deposition Jun 4, 2012 Deposition site : BMRB / Processing site : RCSBRevision 1.0 Nov 21, 2012 Provider : repository / Type : Initial releaseRevision 1.1 May 1, 2024 Group : Data collection / Database referencesCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_nmr_software / pdbx_nmr_spectrometer Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_nmr_software.name / _pdbx_nmr_spectrometer.model
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