Entry Database : PDB / ID : 2ltw Structure visualization Downloads & linksTitle YAP WW1 in complex with a Smad7 derived peptide ComponentsSmad7 derived peptide Yorkie homolog DetailsKeywords PROTEIN BINDING/PEPTIDE / WW / YAP / SMAD7 / PROTEIN BINDING-PEPTIDE complexFunction / homology Function and homology informationFunction Domain/homology Component
positive regulation of chondrocyte hypertrophy / negative regulation of T-helper 17 type immune response / negative regulation of chondrocyte proliferation / negative regulation of T cell cytokine production / enterocyte differentiation / regulation of keratinocyte proliferation / heteromeric SMAD protein complex / regulation of metanephric nephron tubule epithelial cell differentiation / cardiac muscle tissue regeneration / regulation of ventricular cardiac muscle cell membrane depolarization ... positive regulation of chondrocyte hypertrophy / negative regulation of T-helper 17 type immune response / negative regulation of chondrocyte proliferation / negative regulation of T cell cytokine production / enterocyte differentiation / regulation of keratinocyte proliferation / heteromeric SMAD protein complex / regulation of metanephric nephron tubule epithelial cell differentiation / cardiac muscle tissue regeneration / regulation of ventricular cardiac muscle cell membrane depolarization / glandular epithelial cell differentiation / TEAD-YAP complex / negative regulation of T-helper 17 cell differentiation / lateral mesoderm development / RUNX3 regulates YAP1-mediated transcription / bud elongation involved in lung branching / regulation of transforming growth factor beta receptor signaling pathway / polarized epithelial cell differentiation / positive regulation of cell-cell adhesion / response to laminar fluid shear stress / notochord development / negative regulation of cilium assembly / regulation of epithelial to mesenchymal transition / activin receptor binding / lung epithelial cell differentiation / YAP1- and WWTR1 (TAZ)-stimulated gene expression / heart process / trophectodermal cell differentiation / paraxial mesoderm development / regulation of stem cell proliferation / tissue homeostasis / hippo signaling / EGR2 and SOX10-mediated initiation of Schwann cell myelination / negative regulation of transcription by competitive promoter binding / negative regulation of ubiquitin-protein transferase activity / Signaling by BMP / intestinal epithelial cell development / type I transforming growth factor beta receptor binding / negative regulation of epithelial cell apoptotic process / SMAD protein signal transduction / negative regulation of activin receptor signaling pathway / adherens junction assembly / negative regulation of stem cell differentiation / Formation of axial mesoderm / protein-containing complex localization / embryonic heart tube morphogenesis / female germ cell nucleus / negative regulation of epithelial to mesenchymal transition / I-SMAD binding / negative regulation of ossification / Differentiation of keratinocytes in interfollicular epidermis in mammalian skin / proline-rich region binding / Signaling by Hippo / transcription regulator inhibitor activity / ventricular cardiac muscle tissue morphogenesis / artery morphogenesis / ureteric bud development / negative regulation of epithelial cell differentiation / organ growth / ventricular septum morphogenesis / interleukin-6-mediated signaling pathway / positive regulation of Notch signaling pathway / negative regulation of fat cell differentiation / positive regulation of stem cell population maintenance / negative regulation of SMAD protein signal transduction / negative regulation of peptidyl-threonine phosphorylation / RUNX2 regulates osteoblast differentiation / negative regulation of peptidyl-serine phosphorylation / Zygotic genome activation (ZGA) / somatic stem cell population maintenance / negative regulation of BMP signaling pathway / regulation of neurogenesis / regulation of cardiac muscle contraction / ubiquitin-like ligase-substrate adaptor activity / anatomical structure morphogenesis / canonical Wnt signaling pathway / vasculogenesis / positive regulation of osteoblast differentiation / cellular response to retinoic acid / extrinsic apoptotic signaling pathway / Nuclear signaling by ERBB4 / keratinocyte differentiation / positive regulation of cardiac muscle cell proliferation / negative regulation of protein ubiquitination / cellular response to transforming growth factor beta stimulus / collagen binding / transforming growth factor beta receptor signaling pathway / Downregulation of TGF-beta receptor signaling / positive regulation of epithelial cell proliferation / negative regulation of cell migration / epithelial cell proliferation / cellular response to leukemia inhibitory factor / response to progesterone / negative regulation of extrinsic apoptotic signaling pathway / Downregulation of SMAD2/3:SMAD4 transcriptional activity / transcription coregulator activity / SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription / negative regulation of transforming growth factor beta receptor signaling pathway / wound healing / cell morphogenesis Similarity search - Function : / MAD homology, MH1 / Dwarfin / SMAD MH1 domain superfamily / MAD homology domain 1 (MH1) profile. / SMAD domain, Dwarfin-type / MH2 domain / MAD homology domain 2 (MH2) profile. / Domain B in dwarfin family proteins / MAD homology 1, Dwarfin-type ... : / MAD homology, MH1 / Dwarfin / SMAD MH1 domain superfamily / MAD homology domain 1 (MH1) profile. / SMAD domain, Dwarfin-type / MH2 domain / MAD homology domain 2 (MH2) profile. / Domain B in dwarfin family proteins / MAD homology 1, Dwarfin-type / MH1 domain / Domain A in dwarfin family proteins / SMAD-like domain superfamily / SMAD/FHA domain superfamily / WW domain / WW/rsp5/WWP domain signature. / WW domain superfamily / WW/rsp5/WWP domain profile. / Domain with 2 conserved Trp (W) residues / WW domain Similarity search - Domain/homologyBiological species Homo sapiens (human)Method SOLUTION NMR / torsion angle dynamics DetailsAuthors Macias, M.J. / Aragon, E. / Goerner, N. / Xi, Q. / Lopes, T. / Gao, S. / Massague, J. CitationJournal : Structure / Year : 2012Title : Structural Basis for the Versatile Interactions of Smad7 with Regulator WW Domains in TGF-beta Pathways.Authors : Aragon, E. / Goerner, N. / Xi, Q. / Gomes, T. / Gao, S. / Massague, J. / Macias, M.J. History Deposition Jun 4, 2012 Deposition site : BMRB / Processing site : RCSBRevision 1.0 Nov 21, 2012 Provider : repository / Type : Initial releaseRevision 1.1 May 1, 2024 Group : Data collection / Database referencesCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_nmr_software / pdbx_nmr_spectrometer Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_nmr_software.name / _pdbx_nmr_spectrometer.model
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