- PDB-1h15: X-ray crystal structure of HLA-DRA1*0101/DRB5*0101 complexed with... -
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基本情報
登録情報
データベース: PDB / ID: 1h15
タイトル
X-ray crystal structure of HLA-DRA1*0101/DRB5*0101 complexed with a peptide from Epstein Barr Virus DNA polymerase
要素
(HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR ...) x 2
DNA POLYMERASEDNAポリメラーゼ
キーワード
IMMUNE SYSTEM/TRANSFERASE (免疫系) / COMPLEX (MHC-ANTIGEN) / IMMUNE SYSTEM (免疫系) / MHC / HLA / CLASS II / DR2 / DRB5 / EBV / DNA POLYMERASE (DNAポリメラーゼ) / DNA-DIRECTED DNA POLYMERASE (DNAポリメラーゼ) / IMMUNE SYSTEM-TRANSFERASE complex (免疫系)
機能・相同性
機能・相同性情報
: / myeloid dendritic cell antigen processing and presentation / antigen processing and presentation of endogenous peptide antigen via MHC class II / autolysosome membrane / regulation of T-helper cell differentiation / positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation / MHC class II receptor activity / positive regulation of CD4-positive, alpha-beta T cell activation / antigen processing and presentation of peptide or polysaccharide antigen via MHC class II / bidirectional double-stranded viral DNA replication ...: / myeloid dendritic cell antigen processing and presentation / antigen processing and presentation of endogenous peptide antigen via MHC class II / autolysosome membrane / regulation of T-helper cell differentiation / positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation / MHC class II receptor activity / positive regulation of CD4-positive, alpha-beta T cell activation / antigen processing and presentation of peptide or polysaccharide antigen via MHC class II / bidirectional double-stranded viral DNA replication / positive regulation of memory T cell differentiation / exonuclease activity / transport vesicle membrane / polysaccharide binding / Translocation of ZAP-70 to Immunological synapse / Phosphorylation of CD3 and TCR zeta chains / Generation of second messenger molecules / 免疫シナプス / PD-1 signaling / type II interferon-mediated signaling pathway / T cell receptor binding / MHC class II antigen presentation / trans-Golgi network membrane / lumenal side of endoplasmic reticulum membrane / clathrin-coated endocytic vesicle membrane / ER to Golgi transport vesicle membrane / 認識 / peptide antigen assembly with MHC class II protein complex / MHC class II protein complex / positive regulation of T cell mediated cytotoxicity / peptide antigen binding / endocytic vesicle membrane / antigen processing and presentation of exogenous peptide antigen via MHC class II / Interferon gamma signaling / positive regulation of immune response / positive regulation of T cell activation / Downstream TCR signaling / MHC class II protein complex binding / late endosome membrane / T cell receptor signaling pathway / early endosome membrane / 獲得免疫系 / DNA複製 / DNAポリメラーゼ / リソソーム / DNA-directed DNA polymerase activity / 免疫応答 / lysosomal membrane / ゴルジ体 / nucleotide binding / host cell nucleus / 細胞膜 / DNA binding / extracellular exosome / 細胞膜 類似検索 - 分子機能
Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1 / Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1 / MHC class II, beta chain, N-terminal / Class II histocompatibility antigen, beta domain / Class II histocompatibility antigen, beta domain / MHC class II, alpha chain, N-terminal / Class II histocompatibility antigen, alpha domain / Class II histocompatibility antigen, alpha domain / MHC class II, alpha/beta chain, N-terminal / DNA polymerase family B, thumb domain ...Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1 / Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1 / MHC class II, beta chain, N-terminal / Class II histocompatibility antigen, beta domain / Class II histocompatibility antigen, beta domain / MHC class II, alpha chain, N-terminal / Class II histocompatibility antigen, alpha domain / Class II histocompatibility antigen, alpha domain / MHC class II, alpha/beta chain, N-terminal / DNA polymerase family B, thumb domain / DNA polymerase family B signature. / DNA-directed DNA polymerase, family B, conserved site / DNA polymerase family B / DNA polymerase family B, exonuclease domain / DNA-directed DNA polymerase, family B, exonuclease domain / DNA-directed DNA polymerase, family B, multifunctional domain / DNA polymerase, palm domain superfamily / DNA polymerase type-B family / DNA-directed DNA polymerase, family B / MHC classes I/II-like antigen recognition protein / Immunoglobulin/major histocompatibility complex, conserved site / Immunoglobulins and major histocompatibility complex proteins signature. / Immunoglobulin C-Type / Immunoglobulin C1-set / Immunoglobulin C1-set domain / Ribonuclease H superfamily / Ribonuclease H-like superfamily / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / 抗体 / Roll / Immunoglobulin-like fold / DNA/RNA polymerase superfamily / Immunoglobulin-like / サンドイッチ / Mainly Beta / Alpha Beta 類似検索 - ドメイン・相同性
HLA class II histocompatibility antigen, DR alpha chain / DNA polymerase catalytic subunit / HLA class II histocompatibility antigen, DR beta 5 chain / HLA class II histocompatibility antigen, DR beta 5 chain 類似検索 - 構成要素
Group: Advisory / Atomic model ...Advisory / Atomic model / Derived calculations / Non-polymer description / Other / Refinement description / Version format compliance
SHEET THE SHEET STRUCTURE OF THIS MOLECULE IS BIFURCATED. IN ORDER TO REPRESENT THIS FEATURE IN ... SHEET THE SHEET STRUCTURE OF THIS MOLECULE IS BIFURCATED. IN ORDER TO REPRESENT THIS FEATURE IN THE SHEET RECORDS BELOW, TWO SHEETS ARE DEFINED.
A: HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR ALPHA CHAIN B: HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR BETA 1 CHAIN C: DNA POLYMERASE D: HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR ALPHA CHAIN E: HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR BETA 1 CHAIN F: DNA POLYMERASE ヘテロ分子
DNAPOLYMERASE / DNAポリメラーゼ / EPSTEIN BARR VIUS (EBV) DNA POLYMERASE
分子量: 1628.850 Da / 分子数: 2 / 断片: RESIDUES 628-641 / 由来タイプ: 合成 詳細: THE PROTEIN OCCURS NATURALLY IN EBV BUT THE PEPTIDE WAS SYNTHESISED CHEMICALLY 由来: (合成) HUMAN HERPESVIRUS 4 (ヘルペスウイルス) 参照: UniProt: P03198, DNAポリメラーゼ