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データを開く
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基本情報
登録情報 | データベース: PDB / ID: 1cwc | ||||||
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タイトル | IMPROVED BINDING AFFINITY FOR CYCLOPHILIN A BY A CYCLOSPORIN DERIVATIVE SINGLY MODIFIED AT ITS EFFECTOR DOMAIN | ||||||
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![]() | ISOMERASE/IMMUNOSUPPRESSANT / ISOMERASE-IMMUNOSUPPRESSANT COMPLEX / CYCLOPHILIN-CYCLOSPORIN COMPLEX / CYCLOSPORIN A / IMMUNOSUPPRESSANT / CYCLOPHILIN | ||||||
機能・相同性 | ![]() negative regulation of protein K48-linked ubiquitination / negative regulation of viral life cycle / regulation of apoptotic signaling pathway / cell adhesion molecule production / lipid droplet organization / heparan sulfate binding / regulation of viral genome replication / leukocyte chemotaxis / endothelial cell activation / virion binding ...negative regulation of protein K48-linked ubiquitination / negative regulation of viral life cycle / regulation of apoptotic signaling pathway / cell adhesion molecule production / lipid droplet organization / heparan sulfate binding / regulation of viral genome replication / leukocyte chemotaxis / endothelial cell activation / virion binding / Basigin interactions / negative regulation of stress-activated MAPK cascade / cyclosporin A binding / Minus-strand DNA synthesis / Plus-strand DNA synthesis / Uncoating of the HIV Virion / Early Phase of HIV Life Cycle / Integration of provirus / APOBEC3G mediated resistance to HIV-1 infection / Calcineurin activates NFAT / viral release from host cell / positive regulation of viral genome replication / Binding and entry of HIV virion / protein peptidyl-prolyl isomerization / negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway / positive regulation of protein dephosphorylation / Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation / activation of protein kinase B activity / neutrophil chemotaxis / negative regulation of protein phosphorylation / peptidylprolyl isomerase / peptidyl-prolyl cis-trans isomerase activity / positive regulation of protein secretion / Assembly Of The HIV Virion / negative regulation of protein kinase activity / Budding and maturation of HIV virion / neuron differentiation / platelet activation / platelet aggregation / SARS-CoV-1 activates/modulates innate immune responses / unfolded protein binding / integrin binding / protein folding / Platelet degranulation / positive regulation of NF-kappaB transcription factor activity / cellular response to oxidative stress / secretory granule lumen / vesicle / ficolin-1-rich granule lumen / positive regulation of MAPK cascade / response to hypoxia / positive regulation of protein phosphorylation / intracellular membrane-bounded organelle / focal adhesion / apoptotic process / Neutrophil degranulation / protein-containing complex / RNA binding / extracellular space / extracellular exosome / extracellular region / membrane / nucleus / cytoplasm / cytosol 類似検索 - 分子機能 | ||||||
生物種 | ![]() ![]() | ||||||
手法 | ![]() | ||||||
![]() | Mikol, V. | ||||||
![]() | ![]() タイトル: Improved Binding Affinity for Cyclophilin a by a Cyclosporin Derivative Singly Modified at its Effector Domain. 著者: Papageorgiou, C. / Florineth, A. / Mikol, V. #1: ジャーナル: Acta Crystallogr.,Sect.D / 年: 1994 タイトル: Crystallization of the Complex between Cyclophilin a and Cyclosporin Derivatives: The Use of Cross- Seeding. 著者: Mikol, V. / Duc, D. #2: ![]() タイトル: The X-Ray Structure of (Mebm2T)1-Cyclosporin Complexed with Cyclophilin a Provides an Explanation for its Anomalously High Immunosuppressive Activity. 著者: Mikol, V. / Kallen, J. / Walkinshaw, M.D. #3: ![]() タイトル: X-Ray Structure of a Monomeric Cyclophilin A- Cyclosporin a Crystal Complex at 2.1 A Resolution. 著者: Mikol, V. / Kallen, J. / Pflugl, G. / Walkinshaw, M.D. #4: ジャーナル: Nature / 年: 1993 タイトル: X-Ray Structure of a Decameric Cyclophilin- Cyclosporin Crystal Complex. 著者: Pflugl, G. / Kallen, J. / Schirmer, T. / Jansonius, J.N. / Zurini, M.G. / Walkinshaw, M.D. | ||||||
履歴 |
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構造の表示
構造ビューア | 分子: ![]() ![]() |
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PDBx/mmCIF形式 | ![]() | 52.7 KB | 表示 | ![]() |
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PDB形式 | ![]() | 36.7 KB | 表示 | ![]() |
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-検証レポート
文書・要旨 | ![]() | 375.6 KB | 表示 | ![]() |
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文書・詳細版 | ![]() | 377.5 KB | 表示 | |
XML形式データ | ![]() | 5.8 KB | 表示 | |
CIF形式データ | ![]() | 8.8 KB | 表示 | |
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-関連構造データ
関連構造データ | |
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リンク
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集合体
登録構造単位 | ![]()
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単位格子 |
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Atom site foot note | 1: VAL C 5 - LEU C 6 OMEGA = 359.98 PEPTIDE BOND DEVIATES SIGNIFICANTLY FROM TRANS CONFORMATION |
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要素
#1: タンパク質 | 分子量: 18036.504 Da / 分子数: 1 / 由来タイプ: 組換発現 / 由来: (組換発現) ![]() ![]() ![]() 参照: UniProt: P05092, UniProt: P62937*PLUS, peptidylprolyl isomerase |
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#2: タンパク質・ペプチド | ![]() 詳細: 4, N-DIMETHYLNORLEUCINE AT POSITION 8, CYCLOSPORIN IS A CYCLIC UNDECAPEPTIDE. CYCLIZATION IS ACHIEVED BY LINKING THE N- AND THE C- TERMINI. THE CYCLOSPORIN MOLECULE WAS MODIFIED AT POSITION 8 ...詳細: 4, N-DIMETHYLNORLEUCINE AT POSITION 8, CYCLOSPORIN IS A CYCLIC UNDECAPEPTIDE. CYCLIZATION IS ACHIEVED BY LINKING THE N- AND THE C- TERMINI. THE CYCLOSPORIN MOLECULE WAS MODIFIED AT POSITION 8 TO BE 4,N-DIMETHYLNORLEUCINE. 由来: (合成) ![]() |
#3: 水 | ChemComp-HOH / |
構成要素の詳細 | CYCLOSPORI |
-実験情報
-実験
実験 | 手法: ![]() |
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試料調製
結晶 | マシュー密度: 2.12 Å3/Da / 溶媒含有率: 41.89 % |
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結晶化 | *PLUS 手法: unknown |
-データ収集
放射 | 散乱光タイプ: x-ray |
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放射波長 | 相対比: 1 |
反射 | 解像度: 1.86→10 Å / Num. obs: 12126 / % possible obs: 86.2 % / Observed criterion σ(I): 2 |
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解析
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精密化 | 解像度: 1.86→8 Å / Rfactor Rwork: 0.177 / Rfactor obs: 0.177 / σ(F): 2 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
精密化ステップ | サイクル: LAST / 解像度: 1.86→8 Å
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拘束条件 |
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