Author results

4MXE
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HUMAN ESCO1 (ECO1/CTF7 ORTHOLOG), ACETYLTRANSFERASE DOMAIN IN COMPLEX WITH ACETYL-COA
Descriptor:N-acetyltransferase ESCO1, ACETYL COENZYME *A
Authors:Karlberg, T., Wisniewska, M., Thorsell, A.G., Kouznetsova, E., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, I., Kallas, A., Kraulis, P., Kotenyova, T., Moche, M., Nielsen, T.K., Nordlund, P., Nyman, T., Persson, C., Schutz, P., Svensson, L., Tresaugues, L., Van Den Berg, S., Wahlberg, E., Weigelt, J., Welin, M., Schuler, H., Structural Genomics Consortium (SGC)
Deposit date:2013-09-26
Release date:2015-04-08
Last modified:2016-05-18
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Sister Chromatid Cohesion Establishment Factor ESCO1 Operates by Substrate-Assisted Catalysis.
Structure, 24, 2016
2YAD
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BRICHOS DOMAIN OF SURFACTANT PROTEIN C PRECURSOR PROTEIN
Descriptor:SURFACTANT PROTEIN C BRICHOS DOMAIN
Authors:Askarieh, G., Siponen, M.I., Willander, H., Landreh, M., Westermark, P., Nordling, K., Keranen, H., Hermansson, E., Hamvas, A., Nogee, L.M., Bergman, T., Saenz, A., Casals, C., Aqvist, J., Jornvall, H., Presto, J., Johansson, J., Arrowsmith, C.H., Bountra, C., Collins, R., Edwards, A.M., Ekblad, T., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, I., Karlberg, T., Kol, S., Kotenyova, T., Kouznetsova, E., Moche, M., Nyman, T., Nordlund, P., Persson, C., Schuler, H., Thorsell, A.G., Tresaugues, L., van den Berg, S., Wahlberg, E., Weigelt, J., Welin, M., Berglund, H., Knight, S.D.
Deposit date:2011-02-18
Release date:2012-02-15
Last modified:2014-08-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:High Resolution Structure of a Bricos Domain and its Implications for Anti-Amyloid Chaperone Activity on Lung Surgactant Protein C.
Proc.Natl.Acad.Sci.USA, 109, 2012
3V2B
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HUMAN POLY(ADP-RIBOSE) POLYMERASE 15 (ARTD7, BAL3), MACRO DOMAIN 2 IN COMPLEX WITH ADENOSINE-5-DIPHOSPHORIBOSE
Descriptor:Poly [ADP-ribose] polymerase 15, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE
Authors:Karlberg, T., Moche, M., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, I., Kallas, A., Kotenyova, T., Kotzcsh, A., Kraulis, P., Nielsen, T.K., Nordlund, P., Nyman, T., Persson, C., Roos, A.K., Schutz, P., Siponen, M.I., Thorsell, A.G., Tresaugues, L., Van den berg, S., Weigelt, J., Welin, M., Wisniewska, M., Schuler, H., Structural Genomics Consortium (SGC)
Deposit date:2011-12-12
Release date:2011-12-21
Last modified:2013-03-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Recognition of Mono-ADP-Ribosylated ARTD10 Substrates by ARTD8 Macrodomains.
Structure, 21, 2013
3P0L
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HUMAN STEROIDOGENIC ACUTE REGULATORY PROTEIN
Descriptor:Steroidogenic acute regulatory protein, mitochondrial
Authors:Lehtio, L., Siponen, M., Arrowsmith, C.H., Berglund, H., Busam, R.D., Collins, R., Dahlgren, L.G., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Hallberg, B.M., Herman, M.D., Johansson, A., Johansson, I., Kallas, A., Karlberg, T., Kotenyova, T., Moche, M., Nilsson, M.E., Nordlund, P., Nyman, T., Persson, C., Sagemark, J., Sundstrom, M., Svensson, L., Thorsell, A.G., Tresaugues, L., Van Den Berg, S., Weigelt, J., Welin, M., Schuler, H., Structural Genomics Consortium (SGC)
Deposit date:2010-09-29
Release date:2010-11-24
Last modified:2011-09-21
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Comparative structural analysis of lipid binding START domains.
Plos One, 6, 2011
2XSQ
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CRYSTAL STRUCTURE OF HUMAN NUDIX MOTIF 16 (NUDT16) IN COMPLEX WITH IMP AND MAGNESIUM
Descriptor:U8 SNORNA-DECAPPING ENZYME, INOSINIC ACID, MAGNESIUM ION, ...
Authors:Tresaugues, L., Welin, M., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, I., Karlberg, T., Kol, S., Kotenyova, T., Kouznetsova, E., Moche, M., Nyman, T., Persson, C., Schuler, H., Schutz, P., Siponen, M.I., Thorsell, A.G., van den Berg, S., Wahlberg, E., Weigelt, J., Nordlund, P.
Deposit date:2010-09-29
Release date:2010-11-17
Last modified:2017-12-13
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Structural Basis for the Specificity of Human Nudt16 and its Regulation by Inosine Monophosphate.
Plos One, 10, 2015
3P0N
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HUMAN TANKYRASE 2 - CATALYTIC PARP DOMAIN IN COMPLEX WITH AN INHIBITOR
Descriptor:Tankyrase-2, ZINC ION, 7-bromopyrrolo[1,2-a]quinoxalin-4(5H)-one, ...
Authors:Karlberg, T., Siponen, M.I., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, I., Kotenyova, T., Kouznetsova, E., Moche, M., Nordlund, P., Nyman, T., Persson, C., Schutz, P., Sehic, A., Thorsell, A.G., Tresaugues, L., Van Den Berg, S., Wahlberg, E., Weigelt, J., Welin, M., Schuler, H., Structural Genomics Consortium (SGC)
Deposit date:2010-09-29
Release date:2010-10-20
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors
Nat.Biotechnol., 30, 2012
3P0P
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HUMAN TANKYRASE 2 - CATALYTIC PARP DOMAIN IN COMPLEX WITH AN INHIBITOR
Descriptor:Tankyrase-2, ZINC ION, 2-[4-(4-fluorophenyl)piperazin-1-yl]-6-methylpyrimidin-4(3H)-one, ...
Authors:Karlberg, T., Siponen, M.I., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, I., Kotenyova, T., Kouznetsova, E., Moche, M., Nordlund, P., Nyman, T., Persson, C., Schutz, P., Sehic, A., Thorsell, A.G., Tresaugues, L., Van Den Berg, S., Wahlberg, E., Weigelt, J., Welin, M., Schuler, H., Structural Genomics Consortium (SGC)
Deposit date:2010-09-29
Release date:2010-10-20
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors
Nat.Biotechnol., 30, 2012
3P0Q
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HUMAN TANKYRASE 2 - CATALYTIC PARP DOMAIN IN COMPLEX WITH AN INHIBITOR
Descriptor:Tankyrase-2, ZINC ION, N-[2-(4-chlorophenyl)ethyl]-6-methyl[1,2,4]triazolo[4,3-b]pyridazin-8-amine, ...
Authors:Karlberg, T., Siponen, M.I., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, I., Kotenyova, T., Kouznetsova, E., Moche, M., Nordlund, P., Nyman, T., Persson, C., Schutz, P., Sehic, A., Thorsell, A.G., Tresaugues, L., Van Den Berg, S., Wahlberg, E., Weigelt, J., Welin, M., Schuler, H., Structural Genomics Consortium (SGC)
Deposit date:2010-09-29
Release date:2010-10-20
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors
Nat.Biotechnol., 30, 2012
3OLH
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HUMAN 3-MERCAPTOPYRUVATE SULFURTRANSFERASE
Descriptor:3-mercaptopyruvate sulfurtransferase, SULFATE ION, SODIUM ION
Authors:Karlberg, T., Collins, R., Arrowsmith, C.H., Berglund, H., Bountra, C., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, I., Kotenyova, T., Kouznetsova, E., Moche, M., Nordlund, P., Nyman, T., Persson, C., Schutz, P., Sehic, A., Siponen, M.I., Thorsell, A.G., Tresaugues, L., Van Den Berg, S., Wahlberg, E., Weigelt, J., Welin, M., Schuler, H., Structural Genomics Consortium (SGC)
Deposit date:2010-08-26
Release date:2010-09-29
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Human 3-Mercaptopyruvate Sulfurtransferase
To be Published
3MUJ
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EARLY B-CELL FACTOR 3 (EBF3) IPT/TIG AND DIMERIZATION HELICES
Descriptor:Transcription factor COE3, 1,2-ETHANEDIOL, CHLORIDE ION
Authors:Siponen, M.I., Lehtio, L., Arrowsmith, C.H., Bountra, C., Collins, R., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, I., Karlberg, T., Kotenyova, T., Moche, M., Nordlund, P., Nyman, T., Persson, C., Schueler, H., Schutz, P., Svensson, L., Thorsell, A.G., Tresaugues, L., Van Den Berg, S., Wahlberg, E., Weigelt, J., Welin, M., Wisniewska, M., Berglund, H., Structural Genomics Consortium (SGC)
Deposit date:2010-05-03
Release date:2010-06-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Structural Determination of Functional Domains in Early B-cell Factor (EBF) Family of Transcription Factors Reveals Similarities to Rel DNA-binding Proteins and a Novel Dimerization Motif.
J.Biol.Chem., 285, 2010
3N50
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HUMAN EARLY B-CELL FACTOR 3 (EBF3) IPT/TIG AND HLHLH DOMAINS
Descriptor:Transcription factor COE3
Authors:Lehtio, L., Siponen, M.I., Arrowsmith, C.H., Bountra, C., Collins, R., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, I., Karlberg, T., Kotenyova, T., Moche, M., Nordlund, P., Nyman, T., Persson, C., Schuler, H., Schutz, P., Svensson, L., Thorsell, A.G., Tresaugues, L., Van Den Berg, S., Wahlberg, E., Weigelt, J., Welin, M., Wisniewska, M., Berglund, H., Structural Genomics Consortium (SGC)
Deposit date:2010-05-24
Release date:2010-06-16
Last modified:2014-04-16
Method:X-RAY DIFFRACTION (3.102 Å)
Cite:Structural Determination of Functional Domains in Early B-cell Factor (EBF) Family of Transcription Factors Reveals Similarities to Rel DNA-binding Proteins and a Novel Dimerization Motif.
J.Biol.Chem., 285, 2010
3MQI
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HUMAN EARLY B-CELL FACTOR 1 (EBF1) IPT/TIG DOMAIN
Descriptor:Transcription factor COE1, ETHYL MERCURY ION, trimethylamine oxide
Authors:Siponen, M.I., Lehtio, L., Arrowsmith, C.H., Bountra, C., Collins, R., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, I., Karlberg, T., Kotenyova, T., Moche, M., Nordlund, P., Nyman, T., Persson, C., Schueler, H., Schutz, P., Svensson, L., Thorsell, A.G., Tresaugues, L., Van Den Berg, S., Wahlberg, E., Weigelt, J., Welin, M., Wisniewska, M., Berglund, H., Structural Genomics Consortium (SGC)
Deposit date:2010-04-28
Release date:2010-05-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Determination of Functional Domains in Early B-cell Factor (EBF) Family of Transcription Factors Reveals Similarities to Rel DNA-binding Proteins and a Novel Dimerization Motif.
J.Biol.Chem., 285, 2010
3LLM
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CRYSTAL STRUCTURE ANALYSIS OF A RNA HELICASE
Descriptor:ATP-dependent RNA helicase A, MANGANESE (II) ION, CACODYLATE ION, ...
Authors:Schutz, P., Karlberg, T., Collins, R., Arrowsmith, C.H., Berglund, H., Bountra, C., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, A., Johansson, I., Kallas, A., Kraulis, P., Kotenyova, T., Kotzsch, A., Markova, N., Moche, M., Nielsen, T.K., Nordlund, P., Nyman, T., Persson, C., Roos, A.K., Siponen, M.I., Svensson, L., Thorsell, A.G., Tresaugues, L., Van Den Berg, S., Wahlberg, E., Weigelt, J., Welin, M., Wisniewska, M., Schuler, H.M., Structural Genomics Consortium (SGC)
Deposit date:2010-01-29
Release date:2010-05-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of human RNA helicase A (DHX9): structural basis for unselective nucleotide base binding in a DEAD-box variant protein.
J.Mol.Biol., 400, 2010
3LY5
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DDX18 DEAD-DOMAIN
Descriptor:ATP-dependent RNA helicase DDX18, PHOSPHATE ION, MAGNESIUM ION, ...
Authors:Schutz, P., Karlberg, T., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, A., Johansson, I., Kallas, A., Kraulis, P., Kotenyova, T., Kotzsch, A., Markova, N., Moche, M., Nielsen, T.K., Nordlund, P., Nyman, T., Persson, C., Roos, A.K., Siponen, M.I., Svensson, L., Thorsell, A.G., Tresaugues, L., Van Den Berg, S., Wahlberg, E., Weigelt, J., Welin, M., Wisniewska, M., Schuler, H.M., Structural Genomics Consortium (SGC)
Deposit date:2010-02-26
Release date:2010-05-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Comparative Structural Analysis of Human DEAD-Box RNA Helicases.
Plos One, 5, 2010
3MHJ
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HUMAN TANKYRASE 2 - CATALYTIC PARP DOMAIN IN COMPLEX WITH 1-METHYL-3-(TRIFLUOROMETHYL)-5H-BENZO[C][1,8]NAPHTYRIDINE-6-ONE
Descriptor:Tankyrase-2, ZINC ION, 1-methyl-3-(trifluoromethyl)benzo[c][1,8]naphthyridin-6(5H)-one, ...
Authors:Karlberg, T., Schutz, P., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, I., Kotenyova, T., Markova, N., Moche, M., Nordlund, P., Nyman, T., Persson, C., Siponen, M.I., Svensson, L., Thorsell, A.G., Tresaugues, L., Van Den Berg, S., Weigelt, J., Welin, M., Wisniewska, M., Schuler, H., Structural Genomics Consortium (SGC)
Deposit date:2010-04-08
Release date:2010-05-05
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors
Nat.Biotechnol., 30, 2012
3MHK
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HUMAN TANKYRASE 2 - CATALYTIC PARP DOMAIN IN COMPLEX WITH 2-(2-PYRIDYL)-7,8-DIHYDRO-5H-THIINO[4,3-D]PYRIMIDIN-4-OL
Descriptor:Tankyrase-2, ZINC ION, 2-pyridin-2-yl-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-4-ol, ...
Authors:Karlberg, T., Schutz, P., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, I., Kotenyova, T., Markova, N., Moche, M., Nordlund, P., Nyman, T., Persson, C., Siponen, M.I., Svensson, L., Thorsell, A.G., Tresaugues, L., Van Den Berg, S., Weigelt, J., Welin, M., Wisniewska, M., Schuler, H., Structural Genomics Consortium (SGC)
Deposit date:2010-04-08
Release date:2010-05-05
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors
Nat.Biotechnol., 30, 2012
3LS8
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CRYSTAL STRUCTURE OF HUMAN PIK3C3 IN COMPLEX WITH 3-[4-(4-MORPHOLINYL)THIENO[3,2-D]PYRIMIDIN-2-YL]-PHENOL
Descriptor:Phosphatidylinositol 3-kinase catalytic subunit type 3, 3-(4-morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl)phenol, CHLORIDE ION, ...
Authors:Tresaugues, L., Welin, M., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, I., Karlberg, T., Kotenyova, T., Kraulis, P., Moche, M., Nyman, T., Persson, C., Schuler, H., Schutz, P., Siponen, M.I., Thorsell, A.G., Van den Berg, S., Wahlberg, E., Weigelt, J., Wisniewska, M., Nordlund, P., Structural Genomics Consortium (SGC)
Deposit date:2010-02-12
Release date:2010-03-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Crystal structure of human PIK3C3 in complex with 3-[4-(4-Morpholinyl)thieno[3,2-d]pyrimidin-2-yl]-phenol
To be Published
3LYR
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HUMAN EARLY B-CELL FACTOR 1 (EBF1) DNA-BINDING DOMAIN
Descriptor:Transcription factor COE1, ZINC ION, SULFATE ION, ...
Authors:Siponen, M.I., Wisniewska, M., Arrowsmith, C.H., Bountra, C., Collins, R., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, I., Karlberg, T., Kraulis, P., Kotenyova, T., Markova, N., Moche, M., Nordlund, P., Nyman, T., Persson, C., Schuler, H., Schutz, P., Svensson, L., Thorsell, A.G., Tresaugues, L., Van Den Berg, S., Wahlberg, E., Weigelt, J., Welin, M., Berglund, H., Structural Genomics Consortium (SGC)
Deposit date:2010-02-28
Release date:2010-03-16
Last modified:2014-10-08
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Structural Determination of Functional Domains in Early B-cell Factor (EBF) Family of Transcription Factors Reveals Similarities to Rel DNA-binding Proteins and a Novel Dimerization Motif.
J.Biol.Chem., 285, 2010
2X5Y
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HUMAN ZC3HAV1 (ARTD13), C-TERMINAL DOMAIN
Descriptor:ZINC FINGER CCCH-TYPE ANTIVIRAL PROTEIN 1
Authors:Karlberg, T., Schutz, P., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, I., Kallas, A., Kotenyova, T., Kraulis, P., Moche, M., Nordlund, P., Nyman, T., Persson, C., Siponen, M.I., Svensson, L., Thorsell, A.G., Tresaugues, L., Van Den Berg, S., Weigelt, J., Welin, M., Wisniewska, M., Schuler, H.
Deposit date:2010-02-11
Release date:2010-03-02
Last modified:2015-07-15
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Structural Basis for Lack of Adp-Ribosyltransferase Activity in Poly(Adp-Ribose) Polymerase-13/Zinc Finger Antiviral Protein.
J.Biol.Chem., 290, 2015
3KVH
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CRYSTAL STRUCTURE OF HUMAN PROTEIN SYNDESMOS (NUDT16-LIKE PROTEIN)
Descriptor:Protein syndesmos, GLYCEROL, CHLORIDE ION
Authors:Tresaugues, L., Siponen, M.I., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, A., Johansson, I., Kallas, A., Karlberg, T., Kotenyova, T., Kotzsch, A., Kraulis, P., Moche, M., Nielsen, T.K., Nyman, T., Persson, C., Roos, A.K., Schuler, H., Schutz, P., Thorsell, A.G., Van Den Berg, S., Weigelt, J., Welin, M., Wisniewska, M., Nordlund, P., Structural Genomics Consortium (SGC)
Deposit date:2009-11-30
Release date:2010-01-19
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of human protein syndesmos (NUDT16L1)
To be Published
2WWP
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CRYSTAL STRUCTURE OF THE HUMAN LIPOCALIN-TYPE PROSTAGLANDIN D SYNTHASE
Descriptor:PROSTAGLANDIN-H2 D-ISOMERASE, CHLORIDE ION, THIOCYANATE ION
Authors:Roos, A.K., Tresaugues, L., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, A., Johansson, I., Kallas, A., Karlberg, T., Kotyenova, T., Kotzch, A., Kraulis, P., Markova, N., Moche, M., Nielsen, T.K., Nyman, T., Persson, C., Schuler, H., Schutz, P., Siponen, M.I., Svensson, L., Thorsell, A.G., Van Den Berg, S., Wahlberg, E., Weigelt, J., Welin, M., Wisniewska, M., Nordlund, P., Structural Genomics Consortium (SGC)
Deposit date:2009-10-26
Release date:2010-01-12
Last modified:2017-05-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and Dynamic Insights Into Substrate Binding and Catalysis of Human Lipocalin Prostaglandin D Synthase.
J.Lipid Res., 54, 2013
3KR7
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HUMAN TANKYRASE 2 - CATALYTIC PARP DOMAIN
Descriptor:Tankyrase-2, ZINC ION, SULFATE ION, ...
Authors:Karlberg, T., Schutz, P., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, A., Johansson, I., Kallas, A., Kotenyova, T., Kotzsch, A., Kraulis, P., Nielsen, T.K., Moche, M., Nordlund, P., Nyman, T., Persson, C., Siponen, M.I., Thorsell, A.G., Tresaugues, L., Van Den Berg, S., Weigelt, J., Welin, M., Wisniewska, M., Schuler, H., Structural Genomics Consortium (SGC)
Deposit date:2009-11-18
Release date:2009-12-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural basis for the interaction between tankyrase-2 and a potent Wnt-signaling inhibitor.
J.Med.Chem., 53, 2010
3KR8
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HUMAN TANKYRASE 2 - CATALYTIC PARP DOMAIN IN COMPLEX WITH AN INHIBITOR XAV939
Descriptor:Tankyrase-2, ZINC ION, 2-[4-(trifluoromethyl)phenyl]-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-4-ol, ...
Authors:Karlberg, T., Schutz, P., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, A., Johansson, I., Kallas, A., Kotenyova, T., Kotzsch, A., Kraulis, P., Nielsen, T.K., Moche, M., Nordlund, P., Nyman, T., Persson, C., Siponen, M.I., Thorsell, A.G., Tresaugues, L., Van Den Berg, S., Weigelt, J., Welin, M., Wisniewska, M., Schuler, H., Structural Genomics Consortium (SGC)
Deposit date:2009-11-18
Release date:2009-12-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for the interaction between tankyrase-2 and a potent Wnt-signaling inhibitor.
J.Med.Chem., 53, 2010
3KJD
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HUMAN POLY(ADP-RIBOSE) POLYMERASE 2, CATALYTIC FRAGMENT IN COMPLEX WITH AN INHIBITOR ABT-888
Descriptor:Poly [ADP-ribose] polymerase 2, (2R)-2-(7-carbamoyl-1H-benzimidazol-2-yl)-2-methylpyrrolidinium, GLYCEROL
Authors:Karlberg, T., Schutz, P., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, A., Johansson, I., Kallas, A., Kotenyova, T., Kotzsch, A., Kraulis, P., Nielsen, T.K., Moche, M., Nordlund, P., Nyman, T., Persson, C., Roos, A.K., Siponen, M.I., Thorsell, A.G., Tresaugues, L., Van Den Berg, S., Weigelt, J., Welin, M., Wisniewska, M., Schuler, H., Structural Genomics Consortium (SGC)
Deposit date:2009-11-03
Release date:2009-11-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structure of the catalytic domain of human PARP2 in complex with PARP inhibitor ABT-888.
Biochemistry, 49, 2010
3KCZ
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HUMAN POLY(ADP-RIBOSE) POLYMERASE 2, CATALYTIC FRAGMENT IN COMPLEX WITH AN INHIBITOR 3-AMINOBENZAMIDE
Descriptor:Poly [ADP-ribose] polymerase 2, 3-aminobenzamide, GLYCEROL
Authors:Karlberg, T., Schutz, P., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, A., Johansson, I., Kallas, A., Kotenyova, T., Kotzsch, A., Kraulis, P., Nielsen, T.K., Moche, M., Nordlund, P., Nyman, T., Persson, C., Roos, A.K., Siponen, M.I., Thorsell, A.G., Tresaugues, L., Van Den Berg, S., Weigelt, J., Welin, M., Wisniewska, M., Schuler, H., Structural Genomics Consortium (SGC)
Deposit date:2009-10-22
Release date:2009-11-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the catalytic domain of human PARP2 in complex with PARP inhibitor ABT-888.
Biochemistry, 49, 2010