2J91

Crystal structure of Human Adenylosuccinate Lyase in complex with AMP

Replaces:  2J84

Summary for 2J91

Related2J84
DescriptorADENYLOSUCCINATE LYASE, ADENOSINE MONOPHOSPHATE, CHLORIDE ION, ... (5 entities in total)
Functional Keywordsdisease mutation, adenylosuccinase, succino amp-lyase, purine biosynthesis, adenylosuccinate lyase, adenylosuccinase deficiency, amp, adsl, lyase, saicar, purine, s-amp, epilepsy
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains4
Total molecular weight230781.37
Authors
Primary citation
Stenmark, P.,Moche, M.,Arrowsmith, C.,Berglund, H.,Busam, R.,Collins, R.,Edwards, A.,Ericsson, U.B.,Flodin, S.,Flores, A.,Graslund, S.,Hammarstrom, M.,Hallberg, B.M.,Holmberg Schiavone, L.,Hogbom, M.,Johansson, I.,Karlberg, T.,Kosinska, U.,Kotenyova, T.,Magnusdottir, A.,Nilsson, M.E.,Nilsson-Ehle, P.,Nyman, T.,Ogg, D.,Persson, C.,Sagemark, J.,Sundstrom, M.,Uppenberg, J.,Uppsten, M.,Thorsell, A.G.,Van Den Berg, S.,Wallden, K.,Weigelt, J.,Nordlund, P.
Crystal Structure of Human Adenylosuccinate Lyase
To be Published,
Experimental method
X-RAY DIFFRACTION (1.8 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.20670.2%2.6%10.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 2j91
no rotation
Molmil generated image of 2j91
rotated about x axis by 90°
Molmil generated image of 2j91
rotated about y axis by 90°