2J91

Crystal structure of Human Adenylosuccinate Lyase in complex with AMP

Replaces:  2J84

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	ADENYLOSUCCINATE LYASE	polymer	503	57220.6	4	UniProt (P30566) Pfam (PF00206) Pfam (PF10397)	HOMO SAPIENS (HUMAN)	ADENYLOSUCCINASE, ASL, ASASE
2	E, H, K, N (A, B, C, D)	ADENOSINE MONOPHOSPHATE	non-polymer		347.2	4	Chemie (AMP)
3	F, I, L, O (A, B, C, D)	CHLORIDE ION	non-polymer		35.5	4	Chemie (CL)
4	G, J, M, P (A, B, C, D)	GLYCEROL	non-polymer		92.1	4	Chemie (GOL)
5	Q, R, S, T (A, B, C, D)	water	water		18.0	1495	Chemie (HOH)

Sequence modifications

A, B, C, D: -21 - 0 (PDB: 2J91)
A, B, C, D: 1 - 481 (UniProt: P30566)

PDB	External Database	Details
Arg 63	Gln 63	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	228882.3
Non-Polymers*	Number of molecules	12
	Total formula weight	1899.1
All*	Total formula weight	230781.4

*Water molecules are not included.