2J91

Crystal structure of Human Adenylosuccinate Lyase in complex with AMP

Replaces:  2J84

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	ADENYLOSUCCINATE LYASE	polymer	503	57220.6	4	UniProt (P30566) Pfam (PF00206) Pfam (PF10397)	HOMO SAPIENS (HUMAN)	ADENYLOSUCCINASE, ASL, ASASE
2	E, H, K, N (A, B, C, D)	ADENOSINE MONOPHOSPHATE	non-polymer		347.2	4	Chemie (AMP) PubChem (16397049) PubChem (16760266) PubChem (224) PubChem (34768) PubChem (83862) PubChem (40467049) PubChem (40469468) PubChem (446048) PubChem (44348067) PubChem (45358029) PubChem (40459109) PubChem (515384) PubChem (46874558) PubChem (638042) PubChem (46875232) PubChem (57358045) PubChem (57879893) PubChem (57879902) PubChem (5316444) PubChem (5742864) PubChem (177678969) PubChem (6083) PubChem (1549371) PubChem (12163610) PubChem (12358355) PubChem (92144436) PubChem (122197642) PubChem (12358354) PubChem (162290139) PubChem (162946266) PubChem (171699505)
3	F, I, L, O (A, B, C, D)	CHLORIDE ION	non-polymer		35.5	4	Chemie (CL) PubChem (312)
4	G, J, M, P (A, B, C, D)	GLYCEROL	non-polymer		92.1	4	Chemie (GOL) PubChem (753)
5	Q, R, S, T (A, B, C, D)	water	water		18.0	1495	Chemie (HOH)

Sequence modifications

A, B, C, D: -21 - 0 (PDB: 2J91)
A, B, C, D: 1 - 481 (UniProt: P30566)

PDB	External Database	Details
Arg 63	Gln 63	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	228882.3
Non-Polymers*	Number of molecules	12
	Total formula weight	1899.1
All*	Total formula weight	230781.4

*Water molecules are not included.