Author results

6IYC
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RECOGNITION OF THE AMYLOID PRECURSOR PROTEIN BY HUMAN GAMMA-SECRETASE
Descriptor:Nicastrin, Presenilin-1, Gamma-secretase subunit APH-1A, ...
Authors:Zhou, R., Yang, G., Guo, X., Zhou, Q., Lei, J., Shi, Y.
Deposit date:2018-12-14
Release date:2019-01-23
Last modified:2019-03-06
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Recognition of the amyloid precursor protein by human gamma-secretase.
Science, 363, 2019
5XMZ
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VERTICILLIUM EFFECTOR PEVD1
Descriptor:Effector protein PevD1, CALCIUM ION, CHLORIDE ION
Authors:Liu, X., Zhou, R.
Deposit date:2017-05-17
Release date:2017-07-05
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:The asparagine-rich protein NRP interacts with the Verticillium effector PevD1 and regulates the subcellular localization of cryptochrome 2
J. Exp. Bot., 68, 2017
4DNJ
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THE CRYSTAL STRUCTURES OF 4-METHOXYBENZOATE BOUND CYP199A2
Descriptor:Putative cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE, 4-METHOXYBENZOIC ACID, ...
Authors:Zhou, W., Bell, S.G., Yang, W., Tan, A.B.H., Zhou, R., Johnson, E.O.D., Zhang, A., Rao, Z., Wong, L.-L.
Deposit date:2012-02-08
Release date:2012-08-15
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The crystal structures of 4-methoxybenzoate bound CYP199A2 and CYP199A4: structural changes on substrate binding and the identification of an anion binding site
Dalton Trans, 41, 2012
4DNZ
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THE CRYSTAL STRUCTURES OF CYP199A4
Descriptor:Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION, ...
Authors:Zhou, W., Bell, S.G., Yang, W., Tan, A.B.H., Zhou, R., Johnson, E.O.D., Zhang, A., Rao, Z., Wong, L.-L.
Deposit date:2012-02-09
Release date:2012-08-15
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The crystal structures of 4-methoxybenzoate bound CYP199A2 and CYP199A4: structural changes on substrate binding and the identification of an anion binding site
Dalton Trans, 41, 2012
4DO1
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THE CRYSTAL STRUCTURES OF 4-METHOXYBENZOATE BOUND CYP199A4
Descriptor:Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE, 4-METHOXYBENZOIC ACID, ...
Authors:Zhou, W., Bell, S.G., Yang, W., Tan, A.B.H., Zhou, R., Johnson, E.O.D., Zhang, A., Rao, Z., Wong, L.-L.
Deposit date:2012-02-09
Release date:2012-08-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structures of 4-methoxybenzoate bound CYP199A2 and CYP199A4: structural changes on substrate binding and the identification of an anion binding site
Dalton Trans, 41, 2012
4UIS
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THE CRYOEM STRUCTURE OF HUMAN GAMMA-SECRETASE COMPLEX
Descriptor:GAMMA-SECRETASE, LYSOZYME
Authors:Sun, L., Zhao, L., Yang, G., Yan, C., Zhou, R., Zhou, X., Xie, T., Zhao, Y., Wu, S., Li, X., Shi, Y.
Deposit date:2015-04-03
Release date:2015-06-10
Last modified:2017-08-02
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:Structural Basis of Human Gamma-Secretase Assembly.
Proc.Natl.Acad.Sci.USA, 112, 2015
6IDF
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CRYO-EM STRUCTURE OF GAMMA SECRETASE IN COMPLEX WITH A NOTCH FRAGMENT
Descriptor:Nicastrin, Presenilin-1, Gamma-secretase subunit APH-1A, ...
Authors:Yang, G., Zhou, R., Zhou, Q., Guo, X., Yan, C., Ke, M., Lei, J., Shi, Y.
Deposit date:2018-09-09
Release date:2018-12-26
Last modified:2019-01-23
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Structural basis of Notch recognition by human gamma-secretase
Nature, 565, 2019
2EUA
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STRUCTURE AND MECHANISM OF MENF, THE MENAQUINONE-SPECIFIC ISOCHORISMATE SYNTHASE FROM ESCHERICHIA COLI
Descriptor:Menaquinone-specific isochorismate synthase, D(-)-TARTARIC ACID
Authors:Kolappan, S., Kisker, C., Zwahlen, J., Zhou, R., Tonge, P.J.
Deposit date:2005-10-28
Release date:2006-12-05
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Lysine 190 is the catalytic base in MenF, the menaquinone-specific isochorismate synthase from Escherichia coli: implications for an enzyme family.
Biochemistry, 46, 2007
2I6Y
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STRUCTURE AND MECHANISM OF MYCOBACTERIUM TUBERCULOSIS SALICYLATE SYNTHASE, MBTI
Descriptor:Anthranilate synthase component I, putative
Authors:Zwahlen, J., Subramaniapillai, K., Zhou, R., Kisker, C., Tonge, P.J.
Deposit date:2006-08-29
Release date:2007-06-19
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure and mechanism of MbtI, the salicylate synthase from Mycobacterium tuberculosis
Biochemistry, 46, 2007
3NSP
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CRYSTAL STRUCTURE OF TETRAMERIC RXRALPHA-LBD
Descriptor:Retinoid X receptor, alpha
Authors:Zhang, H., Hu, T., Li, L., Zhou, R., Chen, L., Hu, L., Jiang, H., Shen, X.
Deposit date:2010-07-02
Release date:2010-11-17
Last modified:2012-04-11
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Danthron functions as a retinoic X receptor antagonist by stabilizing tetramers of the receptor.
J.Biol.Chem., 286, 2011
3NSQ
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CRYSTAL STRUCTURE OF TETRAMERIC RXRALPHA-LBD COMPLEXED WITH ANTAGONIST DANTHRON
Descriptor:Retinoid X receptor, alpha, 1,8-dihydroxyanthracene-9,10-dione
Authors:Zhang, H., Hu, T., Li, L., Zhou, R., Chen, L., Hu, L., Jiang, H., Shen, X.
Deposit date:2010-07-02
Release date:2010-11-17
Last modified:2012-04-11
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Danthron functions as a retinoic X receptor antagonist by stabilizing tetramers of the receptor.
J.Biol.Chem., 286, 2011
4N0G
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CRYSTAL STRUCTURE OF PYL13-PP2CA COMPLEX
Descriptor:Protein phosphatase 2C 37, Abscisic acid receptor PYL13, ZINC ION, ...
Authors:Li, W., Wang, L., Sheng, X., Yan, C., Zhou, R., Hang, J., Yin, P., Yan, N.
Deposit date:2013-10-01
Release date:2013-11-13
Last modified:2013-12-18
Method:X-RAY DIFFRACTION (2.382 Å)
Cite:Molecular basis for the selective and ABA-independent inhibition of PP2CA by PYL13
Cell Res., 23, 2013
4R12
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CRYSTAL STRUCTURE OF THE GAMMA-SECRETASE COMPONENT NICASTRIN
Descriptor:Putative uncharacterized protein, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Xie, T., Yan, C., Zhou, R., Zhao, Y., Sun, L., Yang, G., Lu, P., Ma, D., Shi, Y.
Deposit date:2014-08-03
Release date:2014-09-17
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structure of the gamma-secretase component nicastrin
Proc.Natl.Acad.Sci.USA, 2014
5A63
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CRYO-EM STRUCTURE OF THE HUMAN GAMMA-SECRETASE COMPLEX AT 3.4 ANGSTROM RESOLUTION.
Descriptor:NICASTRIN, PRESENILIN-1, GAMMA-SECRETASE SUBUNIT APH-1A, ...
Authors:Bai, X., Yan, C., Yang, G., Lu, P., Ma, D., Sun, L., Zhou, R., Scheres, S.H.W., Shi, Y.
Deposit date:2015-06-24
Release date:2015-08-05
Last modified:2017-08-02
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:An Atomic Structure of Human Gamma-Secretase
Nature, 525, 2015
2MW9
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NMR STRUCTURE OF FBP28 WW2 Y438R MUTANT
Descriptor:Transcription elongation regulator 1
Authors:Macias, M.J., Scheraga, H., Sunol, D., Todorovski, T.
Deposit date:2014-11-03
Release date:2014-12-03
Last modified:2015-01-21
Method:SOLUTION NMR
Cite:Folding kinetics of WW domains with the united residue force field for bridging microscopic motions and experimental measurements.
Proc.Natl.Acad.Sci.USA, 111, 2014
2MWA
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NMR STRUCTURE OF FBP28 WW2 MUTANT Y446L
Descriptor:Transcription elongation regulator 1
Authors:Macias, M.J., Scheraga, H., Sunol, D., Todorovski, T.
Deposit date:2014-11-03
Release date:2014-12-03
Last modified:2015-01-21
Method:SOLUTION NMR
Cite:Folding kinetics of WW domains with the united residue force field for bridging microscopic motions and experimental measurements.
Proc.Natl.Acad.Sci.USA, 111, 2014
2MWB
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FBP28 WW2 MUTANT W457F
Descriptor:Transcription elongation regulator 1
Authors:Macias, M.J., Scheraga, H., Sunol, D., Todorovski, T.
Deposit date:2014-11-03
Release date:2014-12-03
Last modified:2015-01-21
Method:SOLUTION NMR
Cite:Folding kinetics of WW domains with the united residue force field for bridging microscopic motions and experimental measurements.
Proc.Natl.Acad.Sci.USA, 111, 2014
2MWD
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NMR STRUCTURE OF FBP28 WW2 MUTANT Y438R DNDC
Descriptor:Transcription elongation regulator 1
Authors:Macias, M.J., Scheraga, H., Sunol, D., Todorovski, T.
Deposit date:2014-11-04
Release date:2014-12-03
Last modified:2015-01-21
Method:SOLUTION NMR
Cite:Folding kinetics of WW domains with the united residue force field for bridging microscopic motions and experimental measurements.
Proc.Natl.Acad.Sci.USA, 111, 2014
2MWE
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NMR STRUCTURE OF FBP28 WW2 MUTANT Y438R, L453A DNDC
Descriptor:Transcription elongation regulator 1
Authors:Macias, M.J., Scheraga, H., Sunol, D., Todorovski, T.
Deposit date:2014-11-04
Release date:2014-12-03
Last modified:2015-01-21
Method:SOLUTION NMR
Cite:Folding kinetics of WW domains with the united residue force field for bridging microscopic motions and experimental measurements.
Proc.Natl.Acad.Sci.USA, 111, 2014
2MWF
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NMR STRUCTURE OF FBP28 WW2 MUTANT Y438R DN
Descriptor:Transcription elongation regulator 1
Authors:Macias, M.J., Scheraga, H., Sunol, D., Todorovski, T.
Deposit date:2014-11-04
Release date:2014-12-03
Last modified:2015-01-21
Method:SOLUTION NMR
Cite:Folding kinetics of WW domains with the united residue force field for bridging microscopic motions and experimental measurements.
Proc.Natl.Acad.Sci.USA, 111, 2014
3TKT
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CRYSTAL STRUCTURE OF CYP108D1 FROM NOVOSPHINGOBIUM AROMATICIVORANS DSM12444
Descriptor:Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE
Authors:Yang, W., Bell, S.G., Wang, H., Zhou, W., Bartlam, M., Wong, L.-L., Rao, Z.
Deposit date:2011-08-29
Release date:2012-02-29
Last modified:2012-05-02
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure and function of CYP108D1 from Novosphingobium aromaticivorans DSM12444: an aromatic hydrocarbon-binding P450 enzyme
Acta Crystallogr.,Sect.D, 68, 2012
2HAI
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CRYSTAL STRUCTURE OF HCV NS5B RNA POLYMERASE IN COMPLEX WITH NOVEL CLASS OF DIHYDROPYRONE-CONTAINING INHIBITOR.
Descriptor:HEPATITIS C VIRUS NS5B RNA POLYMERASE, (6S)-6-CYCLOPENTYL-6-[2-(3-FLUORO-4-ISOPROPOXYPHENYL)ETHYL]-4-HYDROXY-5,6-DIHYDRO-2H-PYRAN-2-ONE
Authors:Li, H., Love, R.L.
Deposit date:2006-06-12
Release date:2006-09-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Identification and structure-based optimization of novel dihydropyrones as potent HCV RNA polymerase inhibitors.
Bioorg.Med.Chem.Lett., 16, 2006
3MK6
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SUBSTRATE AND INHIBITOR BINDING TO PANK
Descriptor:Pantothenate kinase 3, ACETYL COENZYME *A, GLYCEROL
Authors:Yun, M.-K., White, S.W.
Deposit date:2010-04-14
Release date:2010-09-15
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Modulation of Pantothenate Kinase 3 Activity by Small Molecules that Interact with the Substrate/Allosteric Regulatory Domain.
Chem.Biol., 17, 2010
1CQQ
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TYPE 2 RHINOVIRUS 3C PROTEASE WITH AG7088 INHIBITOR
Descriptor:TYPE 2 RHINOVIRUS 3C PROTEASE, 4-{2-(4-FLUORO-BENZYL)-6-METHYL-5-[(5-METHYL-ISOXAZOLE-3-CARBONYL)-AMINO]-4-OXO-HEPTANOYLAMINO}-5-(2-OXO-PYRROLIDIN-3-YL)-PENTANOIC ACID ETHYL ESTER
Authors:Matthews, D., Ferre, R.A.
Deposit date:1999-08-10
Release date:1999-09-20
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes.
Proc.Natl.Acad.Sci.USA, 96, 1999
3KXW
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THE CRYSTAL STRUCTURE OF FATTY ACID AMP LIGASE FROM LEGIONELLA PNEUMOPHILA
Descriptor:Saframycin Mx1 synthetase B, 5'-O-[(S)-(dodecanoyloxy)(hydroxy)phosphoryl]adenosine
Authors:Zhang, Z., Burley, S.K., Swaminathan, S., New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2009-12-04
Release date:2010-03-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.851 Å)
Cite:Structural and Functional Studies of Fatty Acyl Adenylate Ligases from E. coli and L. pneumophila.
J.Mol.Biol., 406, 2011
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