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4G9A
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BU of 4g9a by Molmil
Crystal structure of calcium2+-bound wild-type CD23 lectin domain
Descriptor: CALCIUM ION, GLYCEROL, Low affinity immunoglobulin epsilon Fc receptor
Authors:Yuan, D, Sutton, B.J, Dhaliwal, B.
Deposit date:2012-07-23
Release date:2013-06-26
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.001 Å)
Cite:Ca2+-dependent Structural Changes in the B-cell Receptor CD23 Increase Its Affinity for Human Immunoglobulin E.
J.Biol.Chem., 288, 2013
4GJ0
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BU of 4gj0 by Molmil
Crystal structure of CD23 lectin domain mutant S252A
Descriptor: GLYCEROL, Low affinity immunoglobulin epsilon Fc receptor, SULFATE ION
Authors:Yuan, D, Sutton, B.J, Dhaliwal, B.
Deposit date:2012-08-09
Release date:2013-06-26
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.953 Å)
Cite:Ca2+-dependent Structural Changes in the B-cell Receptor CD23 Increase Its Affinity for Human Immunoglobulin E.
J.Biol.Chem., 288, 2013
4GI0
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BU of 4gi0 by Molmil
Crystal structure of CD23 lectin domain mutant E249A
Descriptor: GLYCEROL, Low affinity immunoglobulin epsilon Fc receptor
Authors:Yuan, D, Sutton, B.J, Dhaliwal, B.
Deposit date:2012-08-08
Release date:2013-06-26
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Ca2+-dependent Structural Changes in the B-cell Receptor CD23 Increase Its Affinity for Human Immunoglobulin E.
J.Biol.Chem., 288, 2013
4G96
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BU of 4g96 by Molmil
Crystal structure of calcium2+-free wild-type CD23 lectin domain
Descriptor: 1,2-ETHANEDIOL, Low affinity immunoglobulin epsilon Fc receptor, SULFATE ION
Authors:Yuan, D, Sutton, B.J, Dhaliwal, B.
Deposit date:2012-07-23
Release date:2013-06-26
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Ca2+-dependent Structural Changes in the B-cell Receptor CD23 Increase Its Affinity for Human Immunoglobulin E.
J.Biol.Chem., 288, 2013
4GK1
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BU of 4gk1 by Molmil
Crystal structure of CD23 lectin domain mutant D270A
Descriptor: GLYCEROL, Low affinity immunoglobulin epsilon Fc receptor, SULFATE ION
Authors:Yuan, D, Sutton, B.J, Dhaliwal, B.
Deposit date:2012-08-10
Release date:2013-06-26
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.236 Å)
Cite:Ca2+-dependent Structural Changes in the B-cell Receptor CD23 Increase Its Affinity for Human Immunoglobulin E.
J.Biol.Chem., 288, 2013
4GKO
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BU of 4gko by Molmil
Crystal structure of the calcium2+-bound human IgE-Fc(epsilon)3-4 bound to its B cell receptor derCD23
Descriptor: CALCIUM ION, Ig epsilon chain C region, Low affinity immunoglobulin epsilon Fc receptor, ...
Authors:Yuan, D, Sutton, B.J, Dhaliwal, B.
Deposit date:2012-08-13
Release date:2013-06-26
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Ca2+-dependent Structural Changes in the B-cell Receptor CD23 Increase Its Affinity for Human Immunoglobulin E.
J.Biol.Chem., 288, 2013
4GJX
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BU of 4gjx by Molmil
Crystal structure of CD23 lectin domain mutant D258A
Descriptor: GLYCEROL, Low affinity immunoglobulin epsilon Fc receptor
Authors:Yuan, D, Sutton, B.J, Dhaliwal, B.
Deposit date:2012-08-10
Release date:2013-06-26
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Ca2+-dependent Structural Changes in the B-cell Receptor CD23 Increase Its Affinity for Human Immunoglobulin E.
J.Biol.Chem., 288, 2013
7X13
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BU of 7x13 by Molmil
Structure of IgG-Fc hexamer
Descriptor: Immunoglobulin gamma-1 heavy chain
Authors:Yuan, D, Weixin, Y, Xiao, F.
Deposit date:2022-02-23
Release date:2023-03-01
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structure of IgG-Fc hexamer
To Be Published
6K41
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BU of 6k41 by Molmil
cryo-EM structure of alpha2BAR-GoA complex
Descriptor: 4-[(1~{S})-1-(2,3-dimethylphenyl)ethyl]-1~{H}-imidazole, Alpha-2A adrenergic receptor,Endolysin,Alpha-2B adrenergic receptor,Alpha-2B adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Yuan, D, Liu, Z, Wang, H.W, Kobilka, B.K.
Deposit date:2019-05-23
Release date:2020-04-15
Last modified:2020-05-13
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Activation of the alpha2Badrenoceptor by the sedative sympatholytic dexmedetomidine.
Nat.Chem.Biol., 16, 2020
6K42
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BU of 6k42 by Molmil
cryo-EM structure of alpha2BAR-Gi1 complex
Descriptor: 4-[(1~{S})-1-(2,3-dimethylphenyl)ethyl]-1~{H}-imidazole, Alpha-2A adrenergic receptor,Endolysin,Alpha-2B adrenergic receptor,Alpha-2B adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Yuan, D, Liu, Z, Wang, H.W, Kobilka, B.K.
Deposit date:2019-05-23
Release date:2020-04-15
Last modified:2020-05-13
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Activation of the alpha2Badrenoceptor by the sedative sympatholytic dexmedetomidine.
Nat.Chem.Biol., 16, 2020
1XKK
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BU of 1xkk by Molmil
EGFR kinase domain complexed with a quinazoline inhibitor- GW572016
Descriptor: Epidermal growth factor receptor, N-{3-CHLORO-4-[(3-FLUOROBENZYL)OXY]PHENYL}-6-[5-({[2-(METHYLSULFONYL)ETHYL]AMINO}METHYL)-2-FURYL]-4-QUINAZOLINAMINE, PHOSPHATE ION
Authors:Wood, E.R, Truesdale, A.T, McDonald, O.B, Yuan, D, Hassell, A, Dickerson, S.H, Ellis, B, Pennisi, C, Horne, E, Lackey, K, Alligood, K.J, Rusnak, D.W, Gilmer, T.M, Shewchuk, L.M.
Deposit date:2004-09-29
Release date:2004-12-07
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells.
Cancer Res., 64, 2004
4EZM
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BU of 4ezm by Molmil
Crystal structure of the human IgE-Fc(epsilon)3-4 bound to its B cell receptor derCD23
Descriptor: Ig epsilon chain C region, Low affinity immunoglobulin epsilon Fc receptor, alpha-D-mannopyranose, ...
Authors:Dhaliwal, B, Yuan, D, Sutton, B.J.
Deposit date:2012-05-03
Release date:2012-07-18
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Crystal structure of IgE bound to its B-cell receptor CD23 reveals a mechanism of reciprocal allosteric inhibition with high affinity receptor Fc{varepsilon}RI.
Proc.Natl.Acad.Sci.USA, 109, 2012
4J6P
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BU of 4j6p by Molmil
Crystal structure of calcium2+-free wild-type CD23 lectin domain (crystal form F)
Descriptor: Low affinity immunoglobulin epsilon Fc receptor
Authors:Dhaliwal, B, Yuan, D, Sutton, B.J.
Deposit date:2013-02-11
Release date:2013-08-28
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Conformational plasticity at the IgE-binding site of the B-cell receptor CD23.
Mol.Immunol., 56, 2013
4J6L
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BU of 4j6l by Molmil
Crystal structure of calcium2+-free wild-type CD23 lectin domain (crystal form C)
Descriptor: Low affinity immunoglobulin epsilon Fc receptor
Authors:Dhaliwal, B, Yuan, D, Sutton, B.J.
Deposit date:2013-02-11
Release date:2013-08-28
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Conformational plasticity at the IgE-binding site of the B-cell receptor CD23.
Mol.Immunol., 56, 2013
7C2E
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BU of 7c2e by Molmil
GLP-1R-Gs complex structure with a small molecule full agonist
Descriptor: 2-[[4-[6-[(4-cyano-2-fluoranyl-phenyl)methoxy]pyridin-2-yl]-3,6-dihydro-2~{H}-pyridin-1-yl]methyl]-3-[[(2~{S})-oxetan-2-yl]methyl]imidazo[4,5-b]pyridine-5-carboxylic acid, Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Ma, H, Yuan, D.P, Huang, W, Wenge, Z, Xu, E.
Deposit date:2020-05-07
Release date:2020-08-26
Last modified:2020-12-16
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Structural insights into the activation of GLP-1R by a small molecule agonist.
Cell Res., 30, 2020
7EJK
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BU of 7ejk by Molmil
Structure of the alpha2A-adrenergic receptor GoA signaling complex bound to oxymetazoline
Descriptor: Alpha-2A adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Xu, J, Cao, S, Liu, Z, Du, Y.
Deposit date:2021-04-02
Release date:2022-04-13
Last modified:2022-10-26
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structural insights into ligand recognition, activation, and signaling of the alpha 2A adrenergic receptor.
Sci Adv, 8, 2022
7EJ0
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BU of 7ej0 by Molmil
Structure of the alpha2A-adrenergic receptor GoA signaling complex
Descriptor: Alpha-2A adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Xu, J, Cao, S, Liu, Z, Du, Y.
Deposit date:2021-04-01
Release date:2022-04-13
Last modified:2022-10-26
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structural insights into ligand recognition, activation, and signaling of the alpha 2A adrenergic receptor.
Sci Adv, 8, 2022
7EJA
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BU of 7eja by Molmil
Structure of the alpha2A-adrenergic receptor GoA signaling complex bound to dexmedetomidine
Descriptor: 4-[(1~{S})-1-(2,3-dimethylphenyl)ethyl]-1~{H}-imidazole, Alpha-2A adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Xu, J, Cao, S, Liu, Z, Du, Y.
Deposit date:2021-04-01
Release date:2022-04-13
Last modified:2023-11-29
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural insights into ligand recognition, activation, and signaling of the alpha 2A adrenergic receptor.
Sci Adv, 8, 2022
7EJ8
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BU of 7ej8 by Molmil
Structure of the alpha2A-adrenergic receptor GoA signaling complex bound to brimonidine
Descriptor: Alpha-2A adrenergic receptor, Brimonidine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Xu, J, Cao, S, Liu, Z, Du, Y.
Deposit date:2021-04-01
Release date:2022-04-13
Last modified:2022-10-26
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural insights into ligand recognition, activation, and signaling of the alpha 2A adrenergic receptor.
Sci Adv, 8, 2022
7FCP
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BU of 7fcp by Molmil
Crystallographic structure of two neutralizing antibodies in complex with SARS-CoV-2 spike receptor-binding Domain (RBD)
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ...
Authors:Zheng, P, Jin, T.
Deposit date:2021-07-15
Release date:2022-06-15
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Ultrapotent neutralizing antibodies against SARS-CoV-2 with a high degree of mutation resistance.
J.Clin.Invest., 132, 2022
7FCQ
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BU of 7fcq by Molmil
Crystallographic structure of neutralizing antibody P14-44 in complex with SARS-CoV-2 spike receptor-binding Domain (RBD)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, P14-44 antibody Fab fragment heavy chain, ...
Authors:Zheng, P, Jin, T.
Deposit date:2021-07-15
Release date:2022-06-15
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Ultrapotent neutralizing antibodies against SARS-CoV-2 with a high degree of mutation resistance.
J.Clin.Invest., 132, 2022
4J6K
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BU of 4j6k by Molmil
Crystal structure of calcium2+-free wild-type CD23 lectin domain (crystal form B)
Descriptor: Low affinity immunoglobulin epsilon Fc receptor, SULFATE ION
Authors:Dhaliwal, B, Pang, M.O.Y, Sutton, B.J.
Deposit date:2013-02-11
Release date:2013-08-28
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Conformational plasticity at the IgE-binding site of the B-cell receptor CD23.
Mol.Immunol., 56, 2013
4J6J
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BU of 4j6j by Molmil
Crystal structure of calcium2+-free wild-type CD23 lectin domain (crystal form A)
Descriptor: Low affinity immunoglobulin epsilon Fc receptor, SULFATE ION
Authors:Dhaliwal, B, Yahya, N, Sutton, B.J.
Deposit date:2013-02-11
Release date:2013-08-28
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Conformational plasticity at the IgE-binding site of the B-cell receptor CD23.
Mol.Immunol., 56, 2013
4J6M
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BU of 4j6m by Molmil
Crystal structure of calcium2+-free wild-type CD23 lectin domain (crystal form D)
Descriptor: Low affinity immunoglobulin epsilon Fc receptor, SULFATE ION
Authors:Dhaliwal, B, Fabiane, S.M, Sutton, B.J.
Deposit date:2013-02-11
Release date:2013-08-28
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Conformational plasticity at the IgE-binding site of the B-cell receptor CD23.
Mol.Immunol., 56, 2013
4J6N
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BU of 4j6n by Molmil
Crystal structure of calcium2+-free wild-type CD23 lectin domain (crystal form E)
Descriptor: Low affinity immunoglobulin epsilon Fc receptor
Authors:Dhaliwal, B, Pang, M.O.Y, Sutton, B.J.
Deposit date:2013-02-11
Release date:2013-08-28
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Conformational plasticity at the IgE-binding site of the B-cell receptor CD23.
Mol.Immunol., 56, 2013

 

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