4EZM

Crystal structure of the human IgE-Fc(epsilon)3-4 bound to its B cell receptor derCD23

Summary for 4EZM

• Entry DOI: 10.2210/pdb4ezm/pdb
• Related: 1FP5 1T8C 1T8D 2H2R 2H2T 2WQR 3H9Y 3H9Z 3HA0
• Descriptor: Ig epsilon chain C region, Low affinity immunoglobulin epsilon Fc receptor, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: immunoglobulin fold lectin, antibody receptor, immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Cell membrane; Single-pass type II membrane protein: P06734
• Total number of polymer chains: 12
• Total formula weight: 252336.04

Authors

Dhaliwal, B.,Yuan, D.,Sutton, B.J. (deposition date: 2012-05-03, release date: 2012-07-18, Last modification date: 2023-09-13)

• Primary citation: Dhaliwal, B.,Yuan, D.,Pang, M.O.,Henry, A.J.,Cain, K.,Oxbrow, A.,Fabiane, S.M.,Beavil, A.J.,McDonnell, J.M.,Gould, H.J.,Sutton, B.J.; Crystal structure of IgE bound to its B-cell receptor CD23 reveals a mechanism of reciprocal allosteric inhibition with high affinity receptor Fc{varepsilon}RI.; Proc.Natl.Acad.Sci.USA, 109:12686-12691, 2012; PubMed: 22802656; DOI: 10.1073/pnas.1207278109

Experimental method

X-RAY DIFFRACTION (3.1 Å)