4EZM
Crystal structure of the human IgE-Fc(epsilon)3-4 bound to its B cell receptor derCD23
Summary for 4EZM
Entry DOI | 10.2210/pdb4ezm/pdb |
Related | 1FP5 1T8C 1T8D 2H2R 2H2T 2WQR 3H9Y 3H9Z 3HA0 |
Descriptor | Ig epsilon chain C region, Low affinity immunoglobulin epsilon Fc receptor, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total) |
Functional Keywords | immunoglobulin fold lectin, antibody receptor, immune system |
Biological source | Homo sapiens (human) More |
Cellular location | Cell membrane; Single-pass type II membrane protein: P06734 |
Total number of polymer chains | 12 |
Total formula weight | 252336.04 |
Authors | Dhaliwal, B.,Yuan, D.,Sutton, B.J. (deposition date: 2012-05-03, release date: 2012-07-18, Last modification date: 2023-09-13) |
Primary citation | Dhaliwal, B.,Yuan, D.,Pang, M.O.,Henry, A.J.,Cain, K.,Oxbrow, A.,Fabiane, S.M.,Beavil, A.J.,McDonnell, J.M.,Gould, H.J.,Sutton, B.J. Crystal structure of IgE bound to its B-cell receptor CD23 reveals a mechanism of reciprocal allosteric inhibition with high affinity receptor Fc{varepsilon}RI. Proc.Natl.Acad.Sci.USA, 109:12686-12691, 2012 Cited by PubMed: 22802656DOI: 10.1073/pnas.1207278109 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
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