Author results

1F0J
  • Download 1f0j
  • View 1f0j
Molmil generated image of 1f0j
CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B2B
Descriptor:PHOSPHODIESTERASE 4B, ZINC ION, MAGNESIUM ION, ...
Authors:Xu, R.X., Hassell, A.M., Vanderwall, D., Lambert, M.H., Holmes, W.D., Luther, M.A., Rocque, W.J., Milburn, M.V., Zhao, Y., Ke, H., Nolte, R.T.
Deposit date:2000-05-16
Release date:2000-07-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Atomic structure of PDE4: insights into phosphodiesterase mechanism and specificity.
Science, 288, 2000
1RO6
  • Download 1ro6
  • View 1ro6
Molmil generated image of 1ro6
CRYSTAL STRUCTURE OF PDE4B2B COMPLEXED WITH ROLIPRAM (R & S)
Descriptor:cAMP-specific 3',5'-cyclic phosphodiesterase 4B, ZINC ION, MANGANESE (II) ION, ...
Authors:Xu, R.X., Rocque, W.J., Lambert, M.H., Vanderwall, D.E., Nolte, R.T.
Deposit date:2003-12-01
Release date:2004-12-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of the catalytic domain of phosphodiesterase 4B complexed with AMP, 8-Br-AMP, and rolipram.
J.Mol.Biol., 337, 2004
1RO9
  • Download 1ro9
  • View 1ro9
Molmil generated image of 1ro9
CRYSTAL STRUCTURES OF THE CATALYTIC DOMAIN OF PHOSPHODIESTERASE 4B2B COMPLEXED WITH 8-BR-AMP
Descriptor:cAMP-specific 3',5'-cyclic phosphodiesterase 4B, ZINC ION, 8-BROMO-ADENOSINE-5'-MONOPHOSPHATE
Authors:Xu, R.X., Rocque, W.J., Lambert, M.H., Vanderwall, D.E., Nolte, R.T.
Deposit date:2003-12-01
Release date:2004-12-07
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Crystal structures of the catalytic domain of phosphodiesterase 4B complexed with AMP, 8-Br-AMP, and rolipram.
J.Mol.Biol., 337, 2004
1ROR
  • Download 1ror
  • View 1ror
Molmil generated image of 1ror
CRYSTAL STRUCTURES OF THE CATALYTIC DOMAIN OF PHOSPHODIESTERASE 4B2B COMPLEXED WITH AMP
Descriptor:cAMP-specific 3',5'-cyclic phosphodiesterase 4B, ZINC ION, ADENOSINE MONOPHOSPHATE
Authors:Xu, R.X., Rocque, W.J., Lambert, M.H., Vanderwall, D.E., Nolte, R.T.
Deposit date:2003-12-02
Release date:2004-12-07
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of the catalytic domain of phosphodiesterase 4B complexed with AMP, 8-Br-AMP, and rolipram.
J.Mol.Biol., 337, 2004
1TBN
  • Download 1tbn
  • View 1tbn
Molmil generated image of 1tbn
NMR STRUCTURE OF A PROTEIN KINASE C-G PHORBOL-BINDING DOMAIN, MINIMIZED AVERAGE STRUCTURE
Descriptor:PROTEIN KINASE C, GAMMA TYPE, ZINC ION
Authors:Xu, R.X., Pawelczyk, T., Xia, T., Brown, S.C.
Deposit date:1997-04-15
Release date:1998-04-29
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:NMR structure of a protein kinase C-gamma phorbol-binding domain and study of protein-lipid micelle interactions.
Biochemistry, 36, 1997
1TBO
  • Download 1tbo
  • View 1tbo
Molmil generated image of 1tbo
NMR STRUCTURE OF A PROTEIN KINASE C-G PHORBOL-BINDING DOMAIN, 30 STRUCTURES
Descriptor:PROTEIN KINASE C, GAMMA TYPE, ZINC ION
Authors:Xu, R.X., Pawelczyk, T., Xia, T., Brown, S.C.
Deposit date:1997-04-15
Release date:1998-04-29
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:NMR structure of a protein kinase C-gamma phorbol-binding domain and study of protein-lipid micelle interactions.
Biochemistry, 36, 1997
1XV9
  • Download 1xv9
  • View 1xv9
Molmil generated image of 1xv9
CRYSTAL STRUCTURE OF CAR/RXR HETERODIMER BOUND WITH SRC1 PEPTIDE, FATTY ACID, AND 5B-PREGNANE-3,20-DIONE.
Descriptor:Retinoic acid receptor RXR-alpha, Orphan nuclear receptor NR1I3, nuclear receptor coactivator 1 isoform 1, ...
Authors:Xu, R.X., Lambert, M.H., Wisely, B.B., Warren, E.N., Weinert, E.E., Waitt, G.M., Williams, J.D., Moore, L.B., Willson, T.M., Moore, J.T.
Deposit date:2004-10-27
Release date:2004-12-28
Last modified:2016-11-30
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A Structural Basis for Constitutive Activity in the Human CAR/RXRalpha Heterodimer.
Mol.Cell, 16, 2004
1XVP
  • Download 1xvp
  • View 1xvp
Molmil generated image of 1xvp
CRYSTAL STRUCTURE OF CAR/RXR HETERODIMER BOUND WITH SRC1 PEPTIDE, FATTY ACID AND CITCO
Descriptor:Retinoic acid receptor RXR-alpha, Orphan nuclear receptor NR1I3, nuclear receptor coactivator 1 isoform 1, ...
Authors:Xu, R.X., Lambert, M.H., Wisely, B.B., Warren, E.N., Weinert, E.E., Waitt, G.M., Williams, J.D., Moore, L.B., Willson, T.M., Moore, J.T.
Deposit date:2004-10-28
Release date:2004-12-28
Last modified:2016-11-30
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A Structural Basis for Constitutive Activity in the Human CAR/RXRalpha Heterodimer.
Mol.Cell, 16, 2004
2P54
  • Download 2p54
  • View 2p54
Molmil generated image of 2p54
A CRYSTAL STRUCTURE OF PPAR ALPHA BOUND WITH SRC1 PEPTIDE AND GW735
Descriptor:Peroxisome proliferator-activated receptor alpha, Nuclear receptor coactivator 1, 2-METHYL-2-(4-{[({4-METHYL-2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOL-5-YL}CARBONYL)AMINO]METHYL}PHENOXY)PROPANOIC ACID
Authors:Xu, R.X., Xu, H.E., Sierra, M.L., Montana, V.G., Lambert, M.H., Pianetti, P.M.
Deposit date:2007-03-14
Release date:2007-04-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Substituted 2-[(4-Aminomethyl)phenoxy]-2-methylpropionic Acid PPAR Agonists. 1.Discovery of a Novel Series of Potent HDLc Raising Agents.
J.Med.Chem., 50, 2007
1HCS
  • Download 1hcs
  • View 1hcs
Molmil generated image of 1hcs
NMR STRUCTURE OF THE HUMAN SRC SH2 DOMAIN COMPLEX
Descriptor:ACETYL-PYEEIE-OH, HUMAN SRC
Authors:Gampe Junior, R.T., Xu, R.X.
Deposit date:1994-09-02
Release date:1995-09-15
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the human pp60c-src SH2 domain complexed with a phosphorylated tyrosine pentapeptide.
Biochemistry, 34, 1995
1HCT
  • Download 1hct
  • View 1hct
Molmil generated image of 1hct
NMR STRUCTURE OF THE HUMAN SRC SH2 DOMAIN COMPLEX
Descriptor:ACETYL-PYEEIE-OH, HUMAN SRC
Authors:Gampe Junior, R.T., Xu, R.X.
Deposit date:1994-09-02
Release date:1995-09-15
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the human pp60c-src SH2 domain complexed with a phosphorylated tyrosine pentapeptide.
Biochemistry, 34, 1995
2FDD
  • Download 2fdd
  • View 2fdd
Molmil generated image of 2fdd
CRYSTAL STRUCTURE OF HIV PROTEASE D545701 BOUND WITH GW0385
Descriptor:Gag-Pol polyprotein, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL [(1S,2R)-3-[(1,3-BENZODIOXOL-5-YLSULFONYL)(ISOBUTYL)AMINO]-2-HYDROXY-1-{4-[(2-METHYL-1,3-THIAZOL-4-YL)METHOXY]BENZYL}PROPYL]CARBAMATE
Authors:Xu, R.X.
Deposit date:2005-12-13
Release date:2006-02-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Ultra-potent P1 modified arylsulfonamide HIV protease inhibitors: The discovery of GW0385.
Bioorg.Med.Chem.Lett., 16, 2006
2FDE
  • Download 2fde
  • View 2fde
Molmil generated image of 2fde
WILD TYPE HIV PROTEASE BOUND WITH GW0385
Descriptor:Gag-Pol polyprotein, POTASSIUM ION, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL [(1S,2R)-3-[(1,3-BENZODIOXOL-5-YLSULFONYL)(ISOBUTYL)AMINO]-2-HYDROXY-1-{4-[(2-METHYL-1,3-THIAZOL-4-YL)METHOXY]BENZYL}PROPYL]CARBAMATE
Authors:Xu, R.X.
Deposit date:2005-12-13
Release date:2006-02-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Ultra-potent P1 modified arylsulfonamide HIV protease inhibitors: The discovery of GW0385.
Bioorg.Med.Chem.Lett., 16, 2006
1URK
  • Download 1urk
  • View 1urk
Molmil generated image of 1urk
SOLUTION STRUCTURE OF THE AMINO TERMINAL FRAGMENT OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR
Descriptor:PLASMINOGEN ACTIVATOR, ALPHA-L-FUCOSE
Authors:Hansen, A.P., Petros, A.M., Meadows, R.P., Nettesheim, D.G., Mazar, A.P., Olejniczak, E.T., Xu, R.X., Pederson, T.M., Henkin, J., Fesik, S.W.
Deposit date:1994-01-10
Release date:1995-05-08
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:Solution structure of the amino-terminal fragment of urokinase-type plasminogen activator.
Biochemistry, 33, 1994
1YMT
  • Download 1ymt
  • View 1ymt
Molmil generated image of 1ymt
MOUSE SF-1 LBD
Descriptor:Steroidogenic factor 1, Nuclear receptor 0B2, 1-CIS-9-OCTADECANOYL-2-CIS-9-HEXADECANOYL PHOSPHATIDYL GLYCEROL
Authors:Krylova, I.N., Sablin, E.P., Moore, J., Xu, R.X., Waitt, G.M., Juzumiene, D., Bynum, J.M., Fletterick, R.J., Willson, T.M., Ingraham, H.A.
Deposit date:2005-01-21
Release date:2005-03-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1
Cell(Cambridge,Mass.), 120, 2005
1YOK
  • Download 1yok
  • View 1yok
Molmil generated image of 1yok
CRYSTAL STRUCTURE OF HUMAN LRH-1 BOUND WITH TIF-2 PEPTIDE AND PHOSPHATIDYLGLYCEROL
Descriptor:Orphan nuclear receptor NR5A2, Nuclear receptor coactivator 2, (2S)-3-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-[(6E)-HEXADEC-6-ENOYLOXY]PROPYL (8E)-OCTADEC-8-ENOATE
Authors:Krylova, I.N., Sablin, E.P., Moore, J., Xu, R.X., Waitt, G.M., MacKay, J.A., Juzumiene, D., Bynum, J.M., Madauss, K., Montana, V., Lebedeva, L., Suzawa, M., Williams, J.D., Williams, S.P., Guy, R.K., Thornton, J.W., Fletterick, R.J., Willson, T.M., Ingraham, H.A.
Deposit date:2005-01-27
Release date:2005-07-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1.
Cell(Cambridge,Mass.), 120, 2005
1YOW
  • Download 1yow
  • View 1yow
Molmil generated image of 1yow
HUMAN STEROIDOGENIC FACTOR 1 LBD WITH BOUND CO-FACTOR PEPTIDE
Descriptor:Steroidogenic factor 1, TIF2 peptide, PHOSPHATIDYL ETHANOL
Authors:Krylova, I.N., Sablin, E.P., Xu, R.X., Waitt, G.M., Juzumiene, D., Williams, J.D., Ingraham, H.A., Willson, T.M., Williams, S.P., Montana, V., Madauss, K.P., Moore, J., Bynum, J.M., Lebedeva, L., MacKay, J.A., Suzawa, M., Guy, R.K., Thornton, J.W.
Deposit date:2005-01-28
Release date:2005-05-10
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1
Cell(Cambridge,Mass.), 120, 2005
3S9S
  • Download 3s9s
  • View 3s9s
Molmil generated image of 3s9s
LIGAND BINDING DOMAIN OF PPARGAMMA COMPLEXED WITH A BENZIMIDAZOLE PARTIAL AGONIST
Descriptor:Peroxisome proliferator-activated receptor gamma, Nuclear receptor coactivator 1, 1-(3,4-dichlorobenzyl)-2-methyl-N-[(1R)-1-phenylpropyl]-1H-benzimidazole-5-carboxamide
Authors:Lambert, M.H., Xu, R.X.
Deposit date:2011-06-02
Release date:2012-06-06
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Discovery of GSK1997132B a novel centrally penetrant benzimidazole PPARgamma partial agonist.
Bioorg.Med.Chem.Lett., 21, 2011
1ARD
  • Download 1ard
  • View 1ard
Molmil generated image of 1ard
STRUCTURES OF DNA-BINDING MUTANT ZINC FINGER DOMAINS: IMPLICATIONS FOR DNA BINDING
Descriptor:YEAST TRANSCRIPTION FACTOR ADR1, ZINC ION
Authors:Hoffman, R.C., Xu, R.X., Horvath, S.J., Herriott, J.R., Klevit, R.E.
Deposit date:1993-10-01
Release date:1994-01-31
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:Structures of DNA-binding mutant zinc finger domains: implications for DNA binding.
Protein Sci., 2, 1993
1ARE
  • Download 1are
  • View 1are
Molmil generated image of 1are
STRUCTURES OF DNA-BINDING MUTANT ZINC FINGER DOMAINS: IMPLICATIONS FOR DNA BINDING
Descriptor:YEAST TRANSCRIPTION FACTOR ADR1, ZINC ION
Authors:Hoffman, R.C., Xu, R.X., Horvath, S.J., Herriott, J.R., Klevit, R.E.
Deposit date:1993-10-01
Release date:1994-01-31
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:Structures of DNA-binding mutant zinc finger domains: implications for DNA binding.
Protein Sci., 2, 1993
1ARF
  • Download 1arf
  • View 1arf
Molmil generated image of 1arf
STRUCTURES OF DNA-BINDING MUTANT ZINC FINGER DOMAINS: IMPLICATIONS FOR DNA BINDING
Descriptor:YEAST TRANSCRIPTION FACTOR ADR1, ZINC ION
Authors:Hoffman, R.C., Xu, R.X., Horvath, S.J., Herriott, J.R., Klevit, R.E.
Deposit date:1993-10-01
Release date:1994-01-31
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:Structures of DNA-binding mutant zinc finger domains: implications for DNA binding.
Protein Sci., 2, 1993
1Y0S
  • Download 1y0s
  • View 1y0s
Molmil generated image of 1y0s
CRYSTAL STRUCTURE OF PPAR DELTA COMPLEXED WITH GW2331
Descriptor:Peroxisome proliferator activated receptor delta, IODIDE ION, (2S)-2-(4-[2-(3-[2,4-DIFLUOROPHENYL]-1-HEPTYLUREIDO)ETHYL]PHENOXY)-2-METHYLBUTYRIC ACID, ...
Authors:Takada, I., Yu, R.T., Xu, H.E., Xu, R.X., Lambert, M.H., Montana, V.G., Kliewer, S.A., Evans, R.M., Umesono, K.
Deposit date:2004-11-16
Release date:2005-03-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Alteration of a Single Amino Acid in Peroxisome Proliferator-Activated Receptor-alpha (PPARalpha) Generates a PPAR delta Phenotype
MOL.ENDOCRINOL., 14, 2000
3DY6
  • Download 3dy6
  • View 3dy6
Molmil generated image of 3dy6
PPARDELTA COMPLEXED WITH AN ANTHRANILIC ACID PARTIAL AGONIST
Descriptor:Peroxisome proliferator-activated receptor delta, IODIDE ION, 2-({[3-(3,4-dihydroisoquinolin-2(1H)-ylsulfonyl)phenyl]carbonyl}amino)benzoic acid
Authors:Lambert, M.L., Xu, R., Shearer, B.G., Wilson, T.M.
Deposit date:2008-07-25
Release date:2008-10-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Discovery of a novel class of PPARdelta partial agonists
Bioorg.Med.Chem.Lett., 18, 2008
3PEQ
  • Download 3peq
  • View 3peq
Molmil generated image of 3peq
PPARD COMPLEXED WITH A PHENOXYACETIC ACID PARTIAL AGONIST
Descriptor:Peroxisome proliferator-activated receptor delta, [(4-{butyl[2-methyl-4'-(methylsulfanyl)biphenyl-3-yl]sulfamoyl}naphthalen-1-yl)oxy]acetic acid, hexyl beta-D-glucopyranoside, ...
Authors:Lambert, M.H., Evans, K.A., Shearer, B.G., Wisnoski, D.D., Shi, D., Jin, J., Rivero, R.A., Sparks, S.M., Winegar, D.A., Billin, A.N., Britt, C., Way, J.M., Leesnitzer, L.M., Merrihew, R.V.
Deposit date:2010-10-27
Release date:2011-10-12
Last modified:2014-10-08
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Phenoxyacetic acid PPARd partial agonists for the treatment of type 2 diabetes: synthesis, optimization, and in vivo efficacy
Bioorg.Med.Chem.Lett., 21, 2011
1PAA
  • Download 1paa
  • View 1paa
Molmil generated image of 1paa
STRUCTURE OF A HISTIDINE-X4-HISTIDINE ZINC FINGER DOMAIN: INSIGHTS INTO ADR1-UAS1 PROTEIN-DNA RECOGNITION
Descriptor:YEAST TRANSCRIPTION FACTOR ADR1, ZINC ION
Authors:Bernstein, B.E., Hoffman, R.C., Horvath, S.J., Herriott, J.R., Klevit, R.E.
Deposit date:1994-07-15
Release date:1994-10-15
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:Structure of a histidine-X4-histidine zinc finger domain: insights into ADR1-UAS1 protein-DNA recognition.
Biochemistry, 33, 1994
PDBj@FacebookPDBj@TwitterwwPDBwwPDB Foundation

Copyright © 2013-2019 Protein Data Bank Japan