1XVP

crystal structure of CAR/RXR heterodimer bound with SRC1 peptide, fatty acid and CITCO

Summary for 1XVP

Related1XV9
DescriptorRetinoic acid receptor RXR-alpha, Orphan nuclear receptor NR1I3, nuclear receptor coactivator 1 isoform 1, ... (6 entities in total)
Functional Keywordscar, rxr, citco, src1, dna binding protein
Biological sourceHomo sapiens (human)
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Cellular locationNucleus Q14994 P19793
Total number of polymer chains8
Total molecular weight117034.52
Authors
Xu, R.X.,Lambert, M.H.,Wisely, B.B.,Warren, E.N.,Weinert, E.E.,Waitt, G.M.,Williams, J.D.,Moore, L.B.,Willson, T.M.,Moore, J.T. (deposition date: 2004-10-28, release date: 2004-12-28, Last modification date: 2016-11-30)
Primary citation
Xu, R.X.,Lambert, M.H.,Wisely, B.B.,Warren, E.N.,Weinert, E.E.,Waitt, G.M.,Williams, J.D.,Collins, J.L.,Moore, L.B.,Willson, T.M.,Moore, J.T.
A Structural Basis for Constitutive Activity in the Human CAR/RXRalpha Heterodimer.
Mol.Cell, 16:919-928, 2004
PubMed: 15610735 (PDB entries with the same primary citation)
DOI: 10.1016/j.molcel.2004.11.042
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.6 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.253262.6%3.4%5.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 1xvp
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Molmil generated image of 1xvp
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Molmil generated image of 1xvp
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More Biological unit images

Molmil generated image of 1xvp
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Molmil generated image of 1xvp
rotated about x axis by 90°
Molmil generated image of 1xvp
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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (1xvp.pdb4.gz [164.13 KB])
Coordinate files for Biological unit (1xvp.pdb5.gz [83.39 KB])
Coordinate files for Biological unit (1xvp.pdb3.gz [168.36 KB])
Coordinate files for Biological unit (1xvp.pdb1.gz [84.93 KB])
Coordinate files for Biological unit (1xvp.pdb2.gz [87.11 KB])