1XVP
crystal structure of CAR/RXR heterodimer bound with SRC1 peptide, fatty acid and CITCO
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003707 | molecular_function | nuclear steroid receptor activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0008270 | molecular_function | zinc ion binding |
| B | 0003677 | molecular_function | DNA binding |
| B | 0004879 | molecular_function | nuclear receptor activity |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| C | 0003677 | molecular_function | DNA binding |
| C | 0003707 | molecular_function | nuclear steroid receptor activity |
| C | 0005634 | cellular_component | nucleus |
| C | 0006355 | biological_process | regulation of DNA-templated transcription |
| C | 0008270 | molecular_function | zinc ion binding |
| D | 0003677 | molecular_function | DNA binding |
| D | 0004879 | molecular_function | nuclear receptor activity |
| D | 0006355 | biological_process | regulation of DNA-templated transcription |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE F15 C 1001 |
| Chain | Residue |
| C | ILE268 |
| C | ALA272 |
| C | GLN275 |
| C | PHE313 |
| C | ARG316 |
| C | LEU326 |
| C | ALA327 |
| C | ILE345 |
| C | CYS432 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE F15 A 1002 |
| Chain | Residue |
| A | ALA272 |
| A | GLN275 |
| A | PHE313 |
| A | ARG316 |
| A | ALA327 |
| A | ILE345 |
| A | CYS432 |
| site_id | AC3 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE CID D 1003 |
| Chain | Residue |
| D | PHE161 |
| D | ASN165 |
| D | MET168 |
| D | VAL199 |
| D | HIS203 |
| D | LEU206 |
| D | PHE217 |
| D | TYR224 |
| D | THR225 |
| D | ASP228 |
| D | GLY229 |
| D | LEU239 |
| D | LEU242 |
| D | PHE243 |
| D | TYR326 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 462 |
| Details | Domain: {"description":"NR LBD","evidences":[{"source":"PROSITE-ProRule","id":"PRU01189","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 40 |
| Details | Region: {"description":"Required for nuclear export","evidences":[{"source":"PubMed","id":"15509776","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16107141","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18800767","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19167885","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2ACL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FAL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FC6","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by MAPK8 and MAPK9","evidences":[{"source":"UniProtKB","id":"P28700","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 16 |
| Details | Motif: {"description":"LXXLL motif 4"} |
| Chain | Residue | Details |
